Kelly

[Kelly @Kelly69020986]

This is the horrifically sad World we live in. No money in cures. A price put on health, safety and life itself.

(I tried to retweet this repeatedly but Twitter won’t let me).

[Kelly @Kelly69020986]

Hope Dr Sinclair and all turn out to be correct

[Jeffrey Flier @jflier]

This paper requires some serious post publication peer review. I hope it happens soon. Kudos to all 59 authors if it’s major conclusion turns out to be true. Serious embarrassment to all if not. @harvardmed @CellCellPress

[David Sinclair @davidasinclair]

* Higher ed doesn’t teach imagination or risk taking
* Academia is less attractive as a career
* Most of the easy problems have been solved
* Hard problems require bigger teams & longer runways
* Govt. grants are risk averse, increasingly applied, and have stagnant budgets

[Peter H. Diamandis, MD @PeterDiamandis]

There is no biological age limit for humans. When will we engineer a cure for aging? It's all about upgrading our human "software." @davidasinclair and I discuss this and more on my latest podcast episode.

[David Sinclair @davidasinclair]

The lessons:
1. Aim the highest you can imagine
2. Don’t listen to the naysayers, they will always criticize what’s new or threatening
3. Never, ever give up. Have grit 
4. Collaborate with people smarter & more skilled than you. It takes a diverse team to do the impossible 7/n

[Blake McCreary @BlakeMcCreary]

@davidasinclair @CellCellPress Just saw this in TIME. https://t.co/VRIkXeRKWv

[David Sinclair @davidasinclair]

@Halsted_19 @rejuvenatebio It was given so late in life and because the viruses aren’t optimized yet. The lifespan extension is still remarkable given how late they intervened. Early days

[David Sinclair @davidasinclair]

@RyanBla00040926 We have done whole body. That’s in this paper. Davidsohn has shown very late life extension with our vectors. Link in thread

[David Sinclair @davidasinclair]

Can this tech extend lifespan? This week Davidsohn and colleagues showed our exact system extends lifespan in very old mice, when initiated at the human equivalent age of 70-80! 10/ https://t.co/9uMikW2OLn

[David Sinclair @davidasinclair]

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

[Allison Duettmann @allisondman]

3 Molecular Nanotech links I love:

Intro: Talk by @EricDrexler https://t.co/UFw8XiaeK0

State of the art: Workshop by @foresightinst https://t.co/KpbjkzN7Eb

Why the time is now: Article by @elidourado https://t.co/DzgiX1MJbF

I collect more here: https://t.co/o5QyUSIYIF

[Antonio Regalado @antonioregalado]

Newest result in "rejuvenation" technology

We report on @rejuvenatebio claim of extending mouse lifespan via partial reprogramming, aka Yamanaka factors.

This was widely sought after result, but life-extension not as dramatic as some daydreamed.

https://t.co/LNvSTb58rs

[Rejuvenate Bio @rejuvenatebio]

How partial reprogramming could be a potential treatment in the elderly to reverse age-associated diseases and potentially extend human lifespan: https://t.co/8oxBywaZ07

[Ian Haydon @ichaydon]

Excited to see my team's work (and my graphics) appear in the New York Times today.

If you thought DALL-E's images were going to change things, wait until you read about what this kind of technology means for medicine and drug discovery.

https://t.co/ungqjd7Us9

[Sean McClain @SeanRMcClain]

🚨 Absci just released a manuscript detailing how zero-shot generative AI can create antibodies from scratch - and of course all wet-lab validated! Literally, target to antibody. First time ever. https://t.co/X1EcY0iCWE

[Chubs 🐲 @CryptoChubs]

@LifespanIO @aubreydegrey Would be interesting to get your thoughts on this article

For decades researchers have looked at curing symptoms of aging instead of the root causes. The notion of reversing aging/curing death comes with a major business proposition
$TYRANT
https://t.co/MRHVuwl7ND

[Aubrey de Grey @aubreydegrey]

@rhmaximalist @lexfridman @MrBeast @elonmusk @joerogan It's frankly horrifying that such a well-informed person evidently doesn't know that the longevity research movement even exists. And Lex doesn't enlighten him, even though he's interviewed Sinclair! (And I just found out one can't use the "WT_" acronym on Twitter...)

[Yuri Deigin @ydeigin]

@Jason My estimate that Covid is a result of a lab leak is 95%. However, I doubt that the particular work which dealt with its bat progenitor was funded by the US — I think this was WIV alone doing research that was originally MEANT to be funded by EcoHealth/DARPA (see DEFUSE proposal).

[David Sinclair @davidasinclair]

From the paper: “Based on our novel mouse population (= >80 years of age in humans) & previous studies in younger mice, we envision therapeutic rejuvenation in aging humans, first in specific age-related disease settings & later for therapeutic healthspan & lifespan extension.”🫶🏼

[David Sinclair @davidasinclair]

Old mice (= human 80) treated with age reprogramming OSK therapy are healthier and longer lived 😯 Will age reversal work in primates #lifebiosciences ? (Caveats: not yet peer reviewed & x-axis doesn’t begin at 0) https://t.co/XIjsPDZT7x

[Matt Kaeberlein @mkaeberlein]

@KristerKauppi @aubreydegrey Never published. We couldn't get funding to expand the study beyond pilot stage, and I didn't have the resources to self-fund. The study section reviewers didn't think it was interesting enough I guess. Unfortunatley, a lot of important science never gets done for this reason