Kidneyman

Nephrology Fellow

[NEJM @NEJM]

𝗦𝘂𝗴𝗴𝗲𝘀𝘁𝗲𝗱 𝗥𝗲𝘃𝗲𝗿𝘀𝗮𝗹 𝗦𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 𝗼𝗳 𝗢𝗿𝗮𝗹 𝗔𝗻𝘁𝗶𝗰𝗼𝗮𝗴𝘂𝗹𝗮𝗻𝘁 𝗨𝘀𝗲 𝗳𝗼𝗿 𝗠𝗮𝗷𝗼𝗿 𝗕𝗹𝗲𝗲𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝗯𝗲𝗳𝗼𝗿𝗲 𝗘𝗺𝗲𝗿𝗴𝗲𝗻𝗰𝘆 𝗦𝘂𝗿𝗴𝗲𝗿𝘆.

As shown in Panel A, reversal management depends on the urgency of surgery or the invasive procedure. Reversal management includes administration of oral or intravenous (IV) vitamin K with or without 4F-PCC, depending on the timing of the procedure (emergency or urgent), baseline international normalized ratio (INR) value, and presence (or absence) of active bleeding. For patients receiving direct oral anticoagulants (DOACs), the decision also depends on time to surgery. Decision making is informed by DOAC type, time since last dose, half-life, presence (or absence) of active bleeding, and renal function tests to estimate residual drug activity.

Panel B shows reversal strategies for patients presenting with major bleeding while receiving an oral anticoagulant. The reversal strategy of vitamin K antagonists includes vitamin K given intravenously or orally, combined with 4F-PCC and INR testing. Management of anticoagulant reversal of direct oral FXaIs is based on four key factors (shown as the 4Ts): type of bleeding, timing of the last dose, thrombotic risk, and need for invasive procedures in the next 48 hours that would result in the administration of UFH. These factors may facilitate the use of specific (e.g., andexanet alfa) or nonspecific (e.g., 4F-PCC) antidotes. The reversal of dabigatran is informed by three clinical variables (shown as the 3Rs) — the type of bleeding, time of the last dose of dabigatran, and preserved renal function.

Learn more in the Review Article “Antidotes for Anticoagulation Reversal” by Bianca Rocca, MD, PhD, and Hugo ten Cate, MD, PhD: https://t.co/XobqwMebfy

NEJM subscribers: Explore this article deeper with AI Companion.

[Edgar V. Lerma 🇵🇭 @edgarvlermamd]

C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms ca. 2026 @SaynaNorouzi #Nephpearls

👉 https://t.co/DCiwi98Xkp

[ASN Publications @asnpublications]

The ASN journals, #ASNCJASN, #ASNJASN, and #ASNKidney360, recognize and honor the outstanding work of junior colleagues in their early stages of nephrology careers by awarding Trainee of the Year awards. Learn more about the opportunity here: https://t.co/qnwY2vzSr6

[Kidneyman @Kidneyman5]

Sir can you share the pdf plz

[Sourabh Sharma @iamnephrologist]

🔆Need to standardise HDF practice & promote wider adoption across 🇮🇳 subcontinent
🔥survival benefit, lower CV complications, lower IDH, better QOL

🔗 https://t.co/C9fCdDxs4N

[Neeraj Agarwal, MD, FASCO @neerajaiims]

Breaking new👉 today @US_FDA approved capivasertib (oral AKT inhibitor) for the metastatic HSPC/APMS #prostatecancer with PTEN deficiency👉personalized medicine continues to leap forward👉Capitello-281 ph3 trial summary👇 @OncoAlert @urotoday @AUC3_Official

[AJKD @AJKDonline]

Transitioning from CKD to Kidney Failure: A Mixed Methods Study of Patient Perspectives

https://t.co/jluQSSr1dZ

@Crystal4kidneys @EmoryRollins @TempleCPH

[Edgar V. Lerma 🇵🇭 @edgarvlermamd]

Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome ca. 2026 from @American_Heart @ACCinTouch @AmDiabetesAssn @ASNKidney
#Nephpearls #Cardiorenal

👉 https://t.co/3vJ2Ik6EeA

[Sourabh Sharma @iamnephrologist]

💥Do you know how René Laennec invented 🩺⁉️

🔥He was a French Physician & musician, skilled in carving wooden flute

🔆First Stethoscope was a 25x2.5cm hollow wooden cylinder

🔆Coined term “Stethoscope"
Greek: στήθος (stethos-chest) + σκοπός (skopos-examination)

Pic-Wiki
#FOAMed #MedTwitter #MedEd #Medicine #medstudent

[Sourabh Sharma @iamnephrologist]

🔆Need to standardise HDF practice & promote wider adoption across 🇮🇳 subcontinent
🔥survival benefit, lower CV complications, lower IDH, better QOL

🔗 https://t.co/C9fCdDxs4N

[CKJ @CKJsocial]

🎥Watch Dr Ozge Hurdogan present the CKJ publication:

Clinicopathologic features and outcomes of patients with DNAJB9 positive fibrillary glomerulonephritis

https://t.co/Ps1VvBgSX2

[CKJ @CKJsocial]

Finding the sweet spot in green nephrology:

the intersection of environmental sustainability and excellence in patient care

https://t.co/yNNKarTD1V

[American Society of Pediatric Nephrology @ASPNeph]

Episode 3 of the ASPN Sediment Podcast is live — listen to it and all past episodes here: https://t.co/10XqIyH1iM

[Sourabh Sharma @iamnephrologist]

⭐Hydration for Healthy Kidneys: Diseases with beneficial effect
1️⃣ADPKD
2️⃣Nephrolithiasis
3️⃣Contrast induced Nephropathy
4️⃣Rhabdomyolysis
5️⃣Meso-American Nephropathy
6️⃣Heat Stress Nephropathy
7️⃣Early stages CKD
⚡Main mech: AVP Suppression
#NephroNotes #Nephpearls @H4HInitiative

[American Society of Pediatric Nephrology @ASPNeph]

Relapsing childhood steroid sensitive nephrotic syndrome: what determines eventual remission?
https://t.co/RhxFACI9lG

[KIReports @KIReports]

Biopsy-based #Transcriptomics in #Banff 2022 Antibody Mediated Rejection Categories #AMR

#VisualAbstract by @DrAkshayaJ

https://t.co/7mKx27Jy0K

@ikemcz @OViklicky

[ASN Publications @asnpublications]

PREVENT-CVD better predicts combined cardio-kidney outcomes in CKD than traditional risk scores, according to #ASNCJASN study. Adding albuminuria boosts performance, highlighting its value for integrated cardio-renal risk assessment. https://t.co/Hweipj78xG

[CKJ @CKJsocial]

Association between nephrolithiasis and kidney disease progression in patients with autosomal dominant polycystic kidney disease: a prospective cohort study

https://t.co/UMHrF5ndU8

[AJKD @AJKDonline]

Special Collection: These articles highlight recent research published in AJKD on developments in kidney transplantation and its impact on donors and recipients.

https://t.co/AR5OVuGPp7 (FREE until August 20, 2026)

[AJKD @AJKDonline]

Is There a Role for Pentoxifylline in Diabetic Kidney Disease?

https://t.co/U4fnhTJi6y (FREE)

@AgarwalRajivMD

[AJKD @AJKDonline]

This core curriculum by @LauraAponteBe & Sherry G. Mansour reviews the physiology of exercise on kidney function and provides evidence-based strategies for patient counseling and risk reduction:

https://t.co/80j7lqvq6j (OPEN ACCESS)

@YaleNephrology