KriesLab

Biosynthetic Design of Natural Products
et KriesLab et mstdn dot science

[KriesLab @KriesLab]

Who decides product specificity in nonribosomal assembly line synthesis? The answer is important for making new antibiotics through #NRPS engineering. Now out @ACSCatalysis. https://t.co/Qhe6E2hDHG Thanks to our collaborators @david_niquille & J. Reinstein @mpi_mr_hd. @LeibnizHKI

[KriesLab @KriesLab]

Yes, I think you should. The twitter crisis is a unique chance to build a better community for scientists on #Mastodon without ads and attention-hogging algorithms. #twexit

https://t.co/DstoCdJkuB

[Leibniz-HKI @LeibnizHKI]

Today we celebrate #WorldScienceDay for Peace and Development 🌍🦠💊🔬🧫🧪🧬
So we asked some of our researchers what motivated them to become scientists:
@microverse_exc @LeibnizWGL @TRR_FungiNet @chembiosys_jena
@Buettner_H @mgblango @KriesLab @zcseresn

[KriesLab @KriesLab]

I love the idea of a free, open-source, and ad-free social network for scientists. I have just made a profile for our lab on @mstdn.science and so far it looks great. A nice community is building there right now.

[KriesLab @KriesLab]

@barra_lena @goetheuni @LacknerLab @andexerlab @HelgeBode_Lab @DoraTang5 @erblabs @RussellCox_Chem @Helfrich_lab @HNiederho @Grininger_Lab

[KriesLab @KriesLab]

@CBeemelmanns @Helmholtz_HZI @Helmholtz_HIPS Good luck for starting the new adventure! You will be missed at HKI.

[KriesLab @KriesLab]

@VaTats Congrats!

[KriesLab @KriesLab]

On bioRxiv: Adenylation multispecificity guided us to find broad evolvability of #nonribosomal surfactin synthetase SrfAC. Provides guidelines which enzyme residues have potential for bioengineering #antibiotics. Congrats Aleksa! @LeibnizHKI @SvenssonCarl https://t.co/eSj2k4PH6e

[Kording Lab 🦖 @KordingLab]

Just my yearly reminder: there is a standard format behind (probably) most published papers. I highly recommend all students look at that format: https://t.co/KY3NRniWhb makes writing easier for my students (and myself)

[KriesLab @KriesLab]

Did you know that an artwork of Beuys once got mopped up by accident? Indiscriminate cleaning up of biosynthetic intermediates can be a loss or a benefit for engineered #NRPS as shown by Farzaneh&Sayan in ACS Chem Bio. @LeibnizHKI @KriesLab @Hertweck_Lab https://t.co/mh2QlGpYzK

[KriesLab @KriesLab]

@AdrianBunzel @ETH_BSSE @snsf_ch @BPL_ethz 🤣🤣🤣

[Leibniz-HKI @LeibnizHKI]

In our institute, we pursue many different approaches to find new therapeutic agents. One cool way is Biosynthetic Design in @KriesLab and it's probably best we let Hajo Kries explain what that is himself:

[BeemelmannsLab @CBeemelmanns]

Happy to share the latest synthesis project: Total Synthesis and Functional Evaluation of IORs, Sulfonolipid‐based Inhibitors of Cell Differentiation in Salpingoeca rosetta https://t.co/oi6n8Jjvf5 @ERC_Research @TRR_FungiNet in collaboration @KriesLab @LeibnizHKI @Choano_Lab

[Michael Ramm @Micha_Ramm]

Great collaboration between @Hertweck_Lab, Michael Groll @TU_Muenchen and @KriesLab funded by @chembiosys_jena, @tmwwdg und other sources

[ManuelMuellerLab @lab_mueller]

Excellent opportunity for a PhD project between @andrecobb and my lab at King's College London: Using photoredox catalysis to manipulate posttranslational modifications! https://t.co/qvFhPZFrhW

[KriesLab @KriesLab]

Congrats Jacob Wurlitzer & Markus Gressler! We recorded substrate profiles in this exciting project on fungal #NRPS. Knowing side-activities helped to develop a biosynthetic strategy for fluorophore-labeled peptides. @LeibnizHKI @ChemicalScience @UniJena https://t.co/uWHIAila46

[KriesLab @KriesLab]

@JeskoKoehnke @dfg_public Looks like the others are jumping while you discovered antigravitation.

[KriesLab @KriesLab]

@erblabs @BILD @mpi_marburg @SYNMIKRO Congrats! Now you always have reality TV as a second option if you get tired of science.

[SYBORG @erblabs]

The morning after: Reading @BILD about #CO2 and our Science @mpi_marburg & @SYNMIKRO

[O'Connor Lab @OConnor_lab]

Biosynthesis of strychnine | Nature. Congratulations Benke. And thanks everyone for your help on this one. https://t.co/I8hd41gX6q