Melnick Lab

Investigating epigenetic and transcriptional dysregulation in hematological malignancies 🧬

[Melnick Lab @LabMelnick]

Check out this incredible new story led by Darko Barisic @edeon from the lab on chromatin remodeling GC B cells and B cell lymphoma!!🔥

[Darko Barisic @LabBarisic]

Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in @Cancer_Cell.
https://t.co/jE1QzkSVXh

More details in the thread below.👇 🧵 1/n

[Darko Barisic @LabBarisic]

Excited to share our other recent paper in @NatureBiotech from Christina Leslie and our lab. We developed and in vivo validated DynaVelo, a deep learning tool that predicts rescue of genetic loss-of-function mutations. Brilliantly led by @karbalayghareh https://t.co/SW1Bv1It1w

[Darko Barisic @LabBarisic]

Beyond thrilled that the first paper from our lab is out today in @nature! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.

https://t.co/RkCBfsbS3W

1/n

[Darko Barisic @LabBarisic]

Thrilled to share we are @theNCI R00-funded. 🥳 Looking for computational biologists or bioinformaticians. 👩‍💻👨‍💻 We have many exciting projects on the role of chromatin remodelers in blood cancers. 🩸🦀 Please share/DM/email if relevant. Our latest story: https://t.co/nnFO97ubl6

[Melnick Lab @LabMelnick]

We are on the cover of Cancer Cell! Check out our latest story on ARID1A and BAF remodeling complex in lymphoma: https://t.co/dRAj8o46D1
Led by @edeon @ChrisRChin.
@WCMLymphoma @WCM_MeyerCancer @WeillCornell @Cancer_Cell

[Weill Cornell Medicine @WeillCornell]

Researchers identify mechanisms that can transform follicular lymphoma into an aggressive form of cancer in some patients.

Findings from a team led by Dr. Ari Melnick (@LabMelnick) of @WCM_MeyerCancer suggest potential for new therapeutic strategies.

https://t.co/MtFPhXEs03

[Cancer Cell @Cancer_Cell]

Online Now: ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis https://t.co/1Xsd6Npi1i

[Quinn @QuinlanSievers]

I learned so much from reading the excellent papers by the Melnick and Green labs and even more when we attempted to distill their observations into a succinct preview article. Check out their work on how BAF complex mutations contribute to lymphomagenesis!

[Melnick Lab @LabMelnick]

and co-published story by @GreenLymphoLab -- great time for epigenetics in the B cell lymphoma field!

[Michael Green, PhD @GreenLymphoLab]

How do BAF (SWI/SNF) mutations drive lymphoma? Back-to-back papers from our group @MDAndersonNews and @LabMelnick lab on SMARCA4 and ARID1A mutations online in @Cancer_Cell today. A brief summary...

https://t.co/eI3MHpmowe

[Melnick Lab @LabMelnick]

Happy Holidays!

[Melnick Lab @LabMelnick]

And please stop by our posters on Sunday and Monday #ASH2023 to learn about more amazing work on DLBCL models and biology! including cool new data by @LScourzic with @efapostolou29 lab

[Melnick Lab @LabMelnick]

Come check out the exciting new work by Yusuke on EZH2 inhibition and CART activity against lymphoma! #ASH2023

[Melnick Lab @LabMelnick]

Interested in learning what chromatin remodelers do in immunity and lymphoma? Dont miss a talk by Darko @edeon from our lab at #ASH2023. @ASH_hematology Monday, Dec 11 — 11:15 AM — Marriott Marquis San Diego Marina, Pacific Ballroom Salons 15-17

[Melnick Lab @LabMelnick]

Check out this remarkable paper from the Julie Leca in the Tak Mak lab! We are honored to have participated in this project. They have some amazing findings regarding interplay between malignant TFH cells and the immune microenvironment!

https://t.co/TU9CUydICC

[Ziv Shulman Lab @ZivShulman]

During antibody affinity maturation in germinal centers (GCs), many defective B cells die by apoptosis. These cells are removed by tingible body macrophages (TBMs). Here, we describe their origin and function. 🧵@NGurwicz https://t.co/kSShMX76Sr @JExpMed

[Cancer Discovery @CD_AACR]

Read this week's Cancer Discovery #ResearchWatch:
Mutations in BTG1 Promote Germinal Center #Bcell Malignant Transformation, a summary of the paper by @coraline_mly, @LabMelnick et al.
https://t.co/XoRSvsRy6A
@WeillCornell

[Melnick Lab @LabMelnick]

@thewrittenro Strong empathy here. I think that is the human condition. But also there are so many wonderful colleagues who make up for it. I try to focus on that positive side, as well the joy of discovery and mentoring trainees - then it is easier to survive those disappointments

[Rochelle A. Burgess @thewrittenro.bsky.social @thewrittenro]

The reason I find academia so hard, is I am wired for a kind of love that this place cannot sustain. I think of ways to cite colleagues, to lift them up, to support them. All the time. It is not reciprocal with so many others. I find it painful. I'm not sure how long I can last.

[New Scientist @newscientist]

Billions of Google searches and billions of YouTube streaming hours each day translate into billions of litres of water needed for cooling Google’s data centres https://t.co/QspdxGhjBX

[Melnick Lab @LabMelnick]

Raise your hand all who enjoy spending all 48 hours of the weekend writing grants!