Leighton H. Duncan

[Yanxiang Deng @DengYanxiang]

Our spatial FFPE-ATAC-seq is now published in @NatureComms! With extensive optimizations, it performs well across diverse tissues, unlocking the vast FFPE archive for spatial epigenomics. Big congrats to Pengfei Guo @pengfeo, Yufan Chen, and the team! https://t.co/zkxgmfTUeG

[Chad Harrison 🇺🇸🇺🇸🇺🇸 @Texas_jeep_guy]

This squirrel had beef with everyone. 🐿️🤣🤣🤣

[Hao Yin @HaoYin20]

Single-cell & spatial omics: exploring hypothalamic heterogeneity
Transcriptomics
Metabolomics
Proteomics

A very rich resource of human mouse #Hypothalamus studies till 2024 (Table 1 & 2😁)

@NRRNeural 2025
https://t.co/oV5MsYQS3X

[Ya'el Courtney, PhD @ScienceYael]

As a former @HHMINEWS Gilliam fellow, I’m deeply disappointed to see HHMI cancel the Hanna Gray this year and pause all competitions.

@leslievosshall, Erin O’Shea — this was a moment to lead with vision, not retreat.

[Erick Armingol @eagut]

I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism!
We infer metabolic activity from single-cell & spatial transcriptomics 🧬
Read the pre-print here👇
📄 https://t.co/u1Al0Ot3Wo

[Rhiana C Simon, PhD @mouse_braind]

Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇

https://t.co/3ZLg0EEStJ

[Kimberley Billingsley @KimberleyBill10]

12/ Finally, this study is part of the CARD long-read sequencing initiative, which aims to sequence thousands of Alzheimer’s Disease and Related Dementias samples from diverse populations to uncover the genetic and epigenetic drivers of these diseases on a global scale.🌍

[Kimberley Billingsley @KimberleyBill10]

8/🧩 Why is this important?
Our findings emphasize the important role of SVs in brain biology. By including ancestrally diverse samples, we’ve built a foundation for inclusive research into how gene regulation impacts neurological diseases. 🌍🧠

[Kimberley Billingsley @KimberleyBill10]

7/ More highlights:
- 34,087,867 small variants 🧬
- Methylation profiles at 28+ million CpG sites 🔬
- This provides a unique opportunity to study the genetic and epigenetic landscape of the brain at an unparalleled resolution.

[Kimberley Billingsley @KimberleyBill10]

9/ This resource lays the groundwork for future studies, enabling:
- Investigations into neurodegenerative disease mechanisms (e.g., ADRD)
- Insights into ancestry-specific genetic variation
Understanding how SVs shape gene expression and DNA methylation

[Kimberley Billingsley @KimberleyBill10]

11/ 📢 Check out the preprint here: https://t.co/vYcbGIJWXU We’d love to hear your feedback, ideas, and collaboration opportunities. 🚀

[Kimberley Billingsley @KimberleyBill10]

10/ 🔬 Open Science! All NAPU outputs (SVs, SNVs, assemblies, mapped BAMs, etc.) will be shared on AnVIL! 🚀The data is currently being uploaded, and we’ll keep you posted when it’s live🔑Note: You’ll need prior dbGaP access to datasets phs001300 and phs000979 to access the data

[Kimberley Billingsley @KimberleyBill10]

Excitingly, lots more data to be released in 2025, and we’re eager to expand this framework to include disease cohorts next! 🎉✨ @cornelisblauw @mike_nalls @SingletonNeuro #LongReadSequencing #Neurogenomics #DiversityInGenomics #OpenScience

[The Milinkovitch-Tzika lab @LANEVOL]

Grigorii & Michel’s method for staining collagen fibres (https://t.co/3rVx86U4cA) has generated multiple award-winning images. Now, we’ve won 3rd prize in @MicroscopyToday’s Published Image category & 1st prize in their Video category!🔬🐁
@UNIGEnews @genevunige @Biologie_UNIGE

[Rory Cooper @rorylcooper]

This is the foot of a chicken embryo after 12 days of development, captured with light sheet microscopy. You can see scutate scales on the top of the foot and reticulate scales on the bottom 🔬🐥

[Shuchen Luo @nemo08061]

CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!

[Nature is Amazing ☘️ @AMAZlNGNATURE]

Turtle Snacking On A Jellyfish

[Nicholas Fabiano, MD @NTFabiano]

We just published the largest review (n=17,290,755) on the safety of psychotropic medications in pregnancy.

https://t.co/DvlfusHiXU

🧵1/12

[dinosaur @dinosaurs1969]

i love my dog but this mf gotta pay rent

[Rodrigo Young @_RodrigoYoung]

Hi again folks, our team @UCLeye in London keeps growing. If you're at the postdoc stage and are interested in the mechanisms that control eye development, growth and disease, apply in this link...
https://t.co/bcdtf1GEqr @ucl @EyeCharity #Zebrafish