Leonard Pastrana

Father-Husband-Cellular Medicine Pharmacist obsessed with human optimization. Striving for the best version of myself so that I can help others reach theirs.

[Leonard Pastrana @LeonardPharmD]

A “NO” VOTE AT PCAC WILL NOT END PEPTIDE USE.

It will determine whether patients access these therapies through physicians and regulated pharmacies or through the unregulated gray market.

[Leonard Pastrana @LeonardPharmD]

New study confirms what patients feel and we see in practice: aging accelerates in midlife.

DNA methylation doesn’t drift linearly—it bends around age 40–60.
That’s when even “healthy” patients show insulin resistance, body comp shifts, and lower recovery.
Traditional medicine calls it “just getting older.”
Longevity medicine knows it’s the turning point for proactive intervention.

Midlife isn’t just middle age—it’s the bend in the curve. https://t.co/NebbOdKF0A

[Leonard Pastrana @LeonardPharmD]

🧬 Patients aren’t bouncing back like they used to.
Even the fit ones. Even the young ones.
Brain fog. Fatigue. Inflammation. Exercise intolerance.

It’s not just “long COVID.”
It’s spike protein-induced biological disruption—reshaping how we age.

This changes everything. ⬇️
https://t.co/d3iMiiyyrl

[Jake Paul @jakepaul]

Your biggest fan is a stranger. Your biggest hater is someone you know. Noodle on that

[Leonard Pastrana @LeonardPharmD]

Longevity medicine isn’t a new specialty. It’s how smart providers future-proof their care model.

[Leonard Pastrana @LeonardPharmD]

@doctorinigo What devices do we have available to use in clinic to measure skeletal muscle adipose?

[Alex Hormozi @AlexHormozi]

What really smart poor people cant handle is that getting rich has less to do with intellect and creativity and more to do with courage and perseverance.

You gotta:
Take risk others wont
Work while others wait
And keep going when others quit

That’s about it. Oh - and wait 10yrs

[Leonard Pastrana @LeonardPharmD]

@doctorinigo How can we as medical practitioners measure intramuscular fat? I have reached out to some companies that provide the device for clinical studies but no luck.

[Navalism @NavalismHQ]

Earn with your mind, not with your time.

@naval

[Good Morning Liberty @GoodAMLiberty]

Phil Donahue died today at the age of 88.

I never get tired of watching one of Milton Friedman’s greatest Donahue moments:

[Dr Alo, DO, FACC @MohammedAlo]

Why Resistance Training Alone Might Not Improve Your CVD Health!

A new study reveals that relying solely on strength training without incorporating aerobic exercise may not reduce cardiovascular mortality risk. To truly protect your heart, cardio is essential alongside muscle-strengthening routines.

Like, Retweet and Bookmark 🔖

7 Key Points From This New Study:-

1️⃣ Hypertension and PA Guidelines:- Hypertension is a major global health issue, and while combining aerobic activities and Muscle strengthening activities effectively manages blood pressure, their combined impact on mortality, particularly in hypertensive individuals, remains unclear. Current guidelines recommend at least 500 MET minutes per week of aerobic activity and muscle-strengthening activities on two or more days weekly to prevent disease and reduce mortality.

2️⃣ Global Adherence to PA Guidelines:- Despite these recommendations, over 80% of adults globally fail to meet both aerobic and Muscle strengthening activities guidelines, with most research focusing on the benefits of aerobic PA alone.

3️⃣ Study Demographics:- Study included 34,990 adults from the 2007 to 2013 Korea National Health and Nutrition Examination Survey, linking mortality follow-up data until 2019.

4️⃣ Result:- The study results shows, In hypertensive individuals, meeting aerobic PA guidelines alone reduced the risk of all-cause and CVD mortality by 24%, while meeting both PA guidelines lowered these risks by 40% and 43%, respectively. However, meeting only MSA guidelines had no significant impact on mortality. In those without hypertension, only meeting both PA guidelines reduced the risk of CVD mortality.

5️⃣ Stronger Effects in Hypertensive Individuals:- The protective effect of meeting aerobic and both PA guidelines, including Muscle strengthening activities, was stronger in individuals with hypertension. This supports findings that those with CVD gain more from PA, potentially due to improved endothelial function and greater blood pressure reduction, which may lower mortality risk.

6️⃣ Limitations of Muscle Strengthening Activities Only Approaches:- Meeting only Muscle strengthening activities guidelines may not provide significant health benefits, particularly for CVD mortality, as suggested by non-significant HR estimates. This indicates that without the recommended level of aerobic PA, Muscle strengthening activities alone might not be sufficient for reducing mortality risk.

7️⃣ Potential Explanations for the Risks of Exclusively Muscle Strengthening Activities:- The potential risks associated with Muscle strengthening activities alone, such as arterial stiffness and mild cardiac hypertrophy from high-volume resistance training, could explain the lack of significant differences in CVD mortality between those who meet only MSA guidelines and those who do not meet either guideline.

Conclusion
While this study highlights that aerobic exercise, in combination with muscle-strengthening activities (MSA), offers significant benefits for reducing cardiovascular mortality, it does not diminish the value of resistance training. Resistance training remains crucial for overall health and fitness. However, for comprehensive cardiovascular protection, it should be paired with aerobic exercise. Emphasizing both components in public health guidelines can provide a more balanced approach to improving heart health and reducing mortality risk.

[Leonard Pastrana @LeonardPharmD]

@DanielJDrucker Doesn’t look like it did.

[Leonard Pastrana @LeonardPharmD]

@Andrea25633402 @DrAndyGalpin This study was done on genetically predicted vo2max.

[Leonard Pastrana @LeonardPharmD]

@spinmonk @johngetstrong @Alan_Couzens @feelthebyrn1 @CalibreBio I found it to be very innacurate.

[Marc Andreessen 🇺🇸 @pmarca]

Whitepill #14: Every day, two lists get longer: The things you believe but can't say, and the things you don't believe but must say.

[Leonard Pastrana @LeonardPharmD]

@EricTopol @NatMetabolism Shocker

[Leonard Pastrana @LeonardPharmD]

@CharlesMBrenner @Longevity_Inv @CharlesMBrenner is it incorrect to say that SIRT1 is an NAD dependent deactlyase and that SIRT 1 deacytlates gene transcription factors like PGC-1a, PPAR, and Nf-Kb?

[Peaceful mind @Peace_mi_1]

15 Deep Philosophy Quotes of "Lao Tzu"

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[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

System‐level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity

https://t.co/LcmcdjjHj8

[Iñigo San Millán @doctorinigo]

Great disruptive article about new thinking around Alzheimer's. Several of us in the field of cellular metabolism have been quietly positing that AD is a metabolic disease due to disrupted cellular bioenergetics & mitochondrial dysfunction. Paradigm shift? https://t.co/T7nzQYfIvL