Lingyin Li Lab

The lab of chemical immunology 🧬 🧫 💊 🐀 Student-run account by lab of @li_lingyin

[Lingyin Li Lab @Lingyin_Lab]

🚨New cGAMP transporter just dropped🚨
Check out the latest preprint from the lab, led by grad student Valentino implicating SLC7A1 as the dominant cGAMP transporter in T cells
https://t.co/xzk6KuCA2w

[Lingyin Li, PhD @li_lingyin]

Congratulations to Zhijian "James" Chen for winning the #Lasker2024 for his foundational discovery of cGAS! https://t.co/zi86CUZPDf

[Lingyin Li Lab @Lingyin_Lab]

@LanT_763 @chembioBryan We're so looking forward to having you in your next chapter!

[Long Lab @longlabstanford]

Today in @nature, we discover a new enzyme in mammalian taurine metabolism- and uncover a chemical connection between diet, genetics, and body weight. Congrats @WeiWei_Stanford @Stanford_ChEMH @StanfordPath @mfgrp @cholsoon_jang @SvenssonLab @Lingyin_Lab
https://t.co/3wSkVL4ikk

[Arc Institute @arcinstitute]

It’s not often we catch all of our Core Investigators in one place, standing still, but we did it! Welcome @FelixHorns - @pdhsu, @SKonermann, @li_lingyin, @LukeGilbertSF, @genophoria and Arc Science Fellows @UcheMedoh and @zhou_jingtian are glad you're here.

[Annemarthe Van der Veen @VanderveenLab]

Such an honour and pleasure to host @Lingyin_Lab in Leiden last Friday on the occasion of the 10th ICI symposium of @ICI_NL. Fabulous talk on STING signalling and oligomerisation, PTMs, ENPP1 and ENPP3!

[Lingyin Li Lab @Lingyin_Lab]

Congratulations Dr. Chris Ritchie on new work defining PELI2 as a negative regulator of STING, now published @MolecularCell!
Read the paper here: https://t.co/wc9aT8CjJh

[Arc Institute @arcinstitute]

🎧 Exciting new discovery from @li_lingyin and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to threats like viral and bacterial infections and cancer. But how does it know when to fight and when to stand down?

Lingyin and Chris found that PELI2 acts like a sensor, filtering out cellular “white noise” that could chronically trigger STING—and lead to inflammatory conditions like lupus and neurodegeneration. At the same time, PELI2 turns into an amplifier when interferon levels grow above a certain threshold, ensuring that STING turns on at the right time.

[Lingyin Li Lab @Lingyin_Lab]

Check out the lab's discovery of the newest player in cancer immunotherapy!
Lead author and protein biochemistry expert @rmardj is also on the job market for those in search of all-around brilliance!

[Arc Institute @arcinstitute]

⚡After discovering the role of the ENPP1 enzyme in masking cancer from the immune system, @Lingyin_Lab has found a new enzyme, ENPP3, that also inhibits cGAMP-STING signal + anti-tumor immune response, preventing immunotherapies like Keytruda from working effectively.
🧵⬇️

[Lingyin Li Lab @Lingyin_Lab]

Read this amazing perspective from our fearless leader looking back at the work that started it all and forward to all that's to come in cancer innate immunotherapy!!

[Lingyin Li, PhD @li_lingyin]

It is a great honor to participate in Cell Chemical biology’s special issue focusing on Inflammasomes and Immunoregulation to celebrate the 30th anniversary of the journal in 2024. Also celebrating 10 years of ENPP1 and extracellular cGAMP. https://t.co/VchlD6Vrta

[Rafa Pinilla-Redondo @rafapinilla92]

How do phages/MGEs overcome bacterial defenses? Delve into our @NatureRevGenet review on 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀 𝗼𝗳 𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 𝗶𝗺𝗺𝘂𝗻𝗶𝘁𝘆!🛡️

We discuss discovery methods, classify mechanisms, & examine their biotech potential!🧬
https://t.co/0V3CgA9DgS 1/11

[Andy Posbe @adnroide]

I'm happy to share ColabFold-Pipeline-Toolkit, an easy recipe book put together to help streamline the use of ColabFold for newcomers without a computing background who want to perform high-throughput screens with ColabFold BATCH. 🧵
https://t.co/QrST6D0laR

[Lingyin Li Lab @Lingyin_Lab]

We are so proud of MD-PhD student and food enthusiast @SongnanWang for her exciting new work characterizing ENPP1 as an innate immune checkpoint for breast cancer! Biggest congratulations to Songnan and coauthors @alby_joseph13 @VSudaryo

[Arc Institute @arcinstitute]

Breast cancer is 1 of the deadliest cancers for women, but <20% respond well to immunotherapy.

New research in @PNAS from Arc Investigator and @Stanford Biochem Prof @li_lingyin + @Stanford grad student Songnan Wang uncovers why. https://t.co/TC3WIYNkG4 🧵

[Lingyin Li Lab @Lingyin_Lab]

Li lab rising star @alby_joseph13 (Jacob Jingleheimer Schmidt) kicks off the @StanfordUChem graduate students Third Year Seminar!

[Lingyin Li Lab @Lingyin_Lab]

Follow (the real) Lingyin and check out new preprint! In short, superstars @rjchan426 and @xujun_cao dig deep into what it takes to activate STING and the best therapeutic strategy to inhibit STING signaling!

[Lingyin Li, PhD @li_lingyin]

My former account was compromised. If you find me here somehow, please add me back to your circle. This article proves that this is the real Lingyin Li and I am not trying to sell you crypto. If you still do not believe me, AMA about STING and cGAMP. https://t.co/3OkPHptUeh

[Lingyin Li Lab @Lingyin_Lab]

🚨New preprint alert 🚨

Check out this work led by @SongnanW on ENPP1 and it’s role as an innate immune checkpoint in breast cancer!

https://t.co/SUkE0SJlJ6

[Lingyin Li Lab @Lingyin_Lab]

Congratulations Dr. Rachel Mardjuki!! Rachel is a protein purification pro and a singing superstar. So proud of you @rmardj!

[Lingyin Li Lab @Lingyin_Lab]

🚨New preprint alert 🚨

Work by Dr. Chris Ritchie shows PELI2’s role in regulating STING activation!

https://t.co/J1UogvJbYv

[Axel R. Concepcion @AxelRConcepcio1]

Don't miss the seminar by prof. Lingyin Li from @Lingyin_Lab @StanfordBiochem this Wednesday at 11am EST: "Extracellular cGAMP signaling in health & Disease"
You can tune in on zoom: https://t.co/2BZs4gs6zv
+Info: https://t.co/CC66XiYS7y
Please share!

[Lingyin Li Lab @Lingyin_Lab]

Celebrated lab achievements over mini golf! Labs that putt-putt together, stay together! ⛳️

[Lingyin Li Lab @Lingyin_Lab]

Congratulations to 2nd year Chemistry student @alby_joseph13 for passing his qualifying exam!

[Alby Joseph (he/him) @alby_joseph13]

This Ken is officially a PhD candidate!