We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development.
https://t.co/4Opufofwop
Excited to present SpaceTravLR, a new framework to uncover functional spatial microniches across contexts. We learn how individual & combinatorial genetic changes rewire regulation & cell-intrinsic + cell-extrinsic signaling across space in tissues. https://t.co/kqTguEOUik (1/2)
Our lab at @YaleMed seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML!
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Also: check out the awesome accompanying paper from @GetYourChorion that uses our tools to pick apart how Nodal signaling dynamics inform morphogenesis!
https://t.co/9TYUaYdcGG
We're very excited to have the final version of our paper up in @Dev_journal. We describe a new system for spatial control of Nodal signaling in live embryos. Thanks to Development for a helpful and constructive review process!
Please reach out if you'd like to try our tools!
Optogenetic control of Nodal signaling patterns
Read this Techniques & Resources Article by Harold McNamara, Alex schier, Adam Cohen, Nathan Lord and colleagues:
https://t.co/X7NQVdq3zP
🎥Direct visualization of photopatterning of live zebrafish embryos
I wrote a 'Behind the Paper' blog post for @the_Node narrating the origin story of our recent @NatureCellBio paper on recording signals during gastruloid symmetry breaking. have a read if you're curious!
https://t.co/t8VrD8W1VF
Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!
My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. https://t.co/2acSQJX4At
Get in on the ground floor! Working with @h4rrymcnamara was a highlight of my scientific career. He is brilliant, creative, and a joy to work with. His lab is going to do awesome things. Definitely seek him out if you're looking to get into developmental biology for PhD/postdoc.
a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute!
We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models.
https://t.co/RIe5kwbg1W
Our paper “Dynamics of morphogen source formation in a growing tissue”
with first authors R. Ho and K. Kishi is published in @PLOSCompBiol 🎉
We show that the floor plate of the vertebrate neural tube forms in two phases: rapid specification followed by growth.
🧵1/7
What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬
https://t.co/J634soGHwz
Working on this paper with @h4rrymcnamara was just an absolute pleasure, one of the highlights of PI life so far.
Even better: he'll be starting his own laboratory in just a few months at Yale - so stay tuned for more exciting work from the McNamara group!