Nathan Lord

Asst. Professor in @compbiopitt. Our lab is interested in cell fate decisions in embryos, noisy signaling and optogenetics.

[Nathan Lord @LordLab_Pitt]

We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development.

https://t.co/4Opufofwop

[Nathan Lord @LordLab_Pitt]

Very excited to be a small part of this awesome paper! Congrats @jishnu1729 and @poholeklab!

[Jishnu Das @jishnu1729]

Excited to present SpaceTravLR, a new framework to uncover functional spatial microniches across contexts. We learn how individual & combinatorial genetic changes rewire regulation & cell-intrinsic + cell-extrinsic signaling across space in tissues. https://t.co/kqTguEOUik (1/2)

[Hattie Chung @hattaca]

Our lab at @YaleMed seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML!

[Nathan Lord @LordLab_Pitt]

@thenormanlab Congrats Tom!! Amazing work.

[Thomas Norman @thenormanlab]

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

[Nathan Lord @LordLab_Pitt]

@hattaca @NIH @YaleMed @YaleCardiology @YaleCVRC @MCDB_Yale @CMUPittCompBio It was so fun to have you! Looking forward to having you visit again someday 😀

[Nathan Lord @LordLab_Pitt]

@mgdurrant So cool! Very excited to give it a read.

[Nathan Lord @LordLab_Pitt]

Also: check out the awesome accompanying paper from @GetYourChorion that uses our tools to pick apart how Nodal signaling dynamics inform morphogenesis!

https://t.co/9TYUaYdcGG

[Nathan Lord @LordLab_Pitt]

We're very excited to have the final version of our paper up in @Dev_journal. We describe a new system for spatial control of Nodal signaling in live embryos. Thanks to Development for a helpful and constructive review process!

Please reach out if you'd like to try our tools!

[Development @Dev_journal]

Optogenetic control of Nodal signaling patterns

Read this Techniques & Resources Article by Harold McNamara, Alex schier, Adam Cohen, Nathan Lord and colleagues:
https://t.co/X7NQVdq3zP
🎥Direct visualization of photopatterning of live zebrafish embryos

[Nathan Lord @LordLab_Pitt]

@MoffittLab @ScienceMagazine Congrats Jeff and team! This looks amazing.

[Harry McNamara @h4rrymcnamara]

I wrote a 'Behind the Paper' blog post for @the_Node narrating the origin story of our recent @NatureCellBio paper on recording signals during gastruloid symmetry breaking. have a read if you're curious!

https://t.co/t8VrD8W1VF

[jared toettcher @toettch]

Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!

[Jue Wang @jueseph]

My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. https://t.co/2acSQJX4At

[Nathan Lord @LordLab_Pitt]

Get in on the ground floor! Working with @h4rrymcnamara was a highlight of my scientific career. He is brilliant, creative, and a joy to work with. His lab is going to do awesome things. Definitely seek him out if you're looking to get into developmental biology for PhD/postdoc.

[Harry McNamara @h4rrymcnamara]

a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute!

We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models.

https://t.co/RIe5kwbg1W

[KichevaLab @KichevaLab]

Our paper “Dynamics of morphogen source formation in a growing tissue”
with first authors R. Ho and K. Kishi is published in @PLOSCompBiol 🎉
We show that the floor plate of the vertebrate neural tube forms in two phases: rapid specification followed by growth.
🧵1/7

[Amjad Askary @AskaryLab]

What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬
https://t.co/J634soGHwz

[jared toettcher @toettch]

Working on this paper with @h4rrymcnamara was just an absolute pleasure, one of the highlights of PI life so far.

Even better: he'll be starting his own laboratory in just a few months at Yale - so stay tuned for more exciting work from the McNamara group!

[Nathan Lord @LordLab_Pitt]

@IdseHeemskerk Congrats @IdseHeemskerk! Excited to dig into this.

[Idse Heemskerk @IdseHeemskerk]

Check out our latest preprint on FGF/ERK signaling in 2D gastruloids:
https://t.co/ZTPmLHZfyZ

[Nathan Lord @LordLab_Pitt]

@summerbthyme @NICHD_NIH Amazing, Summer! You're doing such wonderful things.