Lucia Natarelli

Principal Investigator / Researcher on ncRNAs and epigenetic signatures in cardiovascular diseases at the Institute for Cardiovascular Diseases (IPEK), LMU

[Eric Topol @EricTopol]

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—outgrowth of decades of NIH funded research
https://t.co/HmJxYWDCV7
https://t.co/4DsNELnBut @NEJM
https://t.co/y7NMGPpXnE

[Francesco Paneni @FrancescoPaneni]

Red blood cells drive endothelial dysfunction in #diabetes! Read our article in @jclinicalinvest where we discuss the recent findings from the #PernowLab:
https://t.co/AZ3XQlAwuz
@CTECresearch #SarahCostantino @shafeeq_moham @GoricaEra

[The Nobel Prize @NobelPrize]

How much do you know about the longest-living Nobel Prize laureate ever?

Learn more about medicine laureate Rita Levi-Montalcini who discovered nerve growth factor and was 103 years old when she passed away in 2012.

#NobelPrize

[Hao Yin @HaoYin20]

#Heterochromatin #Mechanobiolgy

Pulsatile #LaminarShearStress induces a sustained ⏫SUV39H1 (histone methyltransferase) & H3K9me3 enrichment on gene promoters of inflammatory genes (E-selectin VCAM1) in #EndothelialCells

In contrast, #OscillatoryShearStress only causes a transient (1 h)⏫SUV39H1 & H3K9me3

SUV39H1 physically interacts with Emerin➡️nuclear peripheral enrichment of H3K9me3 & genomic loci of SELE & VCAM1

siRNA knockdown of Emerin⏬EC F-actin, SUV39H1, H3K9me3; ⏫VCAM1 E-selectin
likely⏬mechanotransduction into nuclei
any impact on alignment to flow?😁

@ucsdbe @PNASNews 2025
https://t.co/itNzc0rGlh

[Lucia Natarelli @LucyAlias]

#EASCongress2025

[Lucia Natarelli @LucyAlias]

Science & fun! Exiting moments at the @EASCongress where also the #ipek Institute from @LMU_Muenchen was here represented by an amazing woman’s team!

[azin kheirkhah @azinkh96]

🔈Excellent presentations are being delivered at the Workshop on Inflammatory Mechanisms in Atherosclerosis!
#EASCongress2025 @society_eas

[Lucia Natarelli @LucyAlias]

Super proud of my postdoc Zahra that made her first talk within the SaaG EAS session!!! #EASCongress2025 @society_eas the first of many other amazing moments !!! 😊

[Lucia Natarelli @LucyAlias]

Finally here!!! A new exciting experience will start at the #eascongress2025 @EASCongress starting with an amazing landscape of Glasgow!

[Lucia Natarelli @LucyAlias]

#ncRNAs #disease

[Lucia Natarelli @LucyAlias]

The new Topic "Non-Coding RNAs as Regulators of Cellular Function and Disease" https://t.co/UQdEXggYSy #mdpicells via @Cells_MDPI is open and ready for submissions !

[Lucia Natarelli @LucyAlias]

Excited to invite you to contribute at our newly launched Research Topic on Frontiers in Immunology: "Role of Genotoxic Stressors and Survival / Metabolic Pathways in Inflammatory Activation and Cell Recruitment in Cardiovascular Diseases". https://t.co/y73AdPpgTj

[Broad Institute @broadinstitute]

Congratulations to Broad associate member Gary Ruvkun and Victor Ambros of @UMassChan for receiving the 2024 @NobelPrize in Physiology or Medicine for the discovery of microRNA! #NobelPrize

[Lucia Natarelli @LucyAlias]

#avaaz #indigenous #biodiversity #HumanRights

[Lucia Natarelli @LucyAlias]

Indigenous Peoples protect the world's forests and precious biodiversity, but they cannot continue to do so if their lives and lands are continually put at risk. Join indigenous leaders demanding land rights here: https://t.co/eMRbPlxQuU

[zack chiang @z_chiang]

7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies

Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing

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[Eric Topol @EricTopol]

An exciting advance in Type 1 diabetes
First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it!
@CellCellPress
https://t.co/NzhTO6tZrg
@Nature
https://t.co/zbNNtLCrot

[Peter Ly @PeterLyLab]

Our paper defining how distinct DSB repair mechanisms re-assemble shattered chromosomes from micronuclei is now published! @Emily_Qing identified c-NHEJ as the major pathway and monitored the kinetics of repair and DNA rearrangements across the cell cycle.
https://t.co/FKVGtaKwI8

[Hao Yin @HaoYin20]

My continued biological education

Histone degradation by the #Proteasome regulates chromatin & cellular plasticity

How long-lived Histones get degraded within 1 h upon dissociated with Chromatin? -> Proteasome in nuclei, Autophagy in cytosol

When?-> DNA damage, Transcription, Tumor, Neuronal plasticity, Spermatogenesis

1/

Yifat Merbl lab @FEBS_Letters 2021
https://t.co/NImokYsoiI

[Nature Portfolio @NaturePortfolio]

Two papers in @Nature present a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. The approach may provide an easier method of genome editing.
https://t.co/EwMQtgoTrE
https://t.co/ecUGLy4l2O