MANGO LAB

Genomics, adaptation, transposable elements, extrachromosomal DNA, horizontal transfer, crop, ecosystems

[Tilly (Matilda) S Scott @TillySScott]

I think the picture got lost the first time, let 's try that again.

Here are all 25 talks together!

[Patrick Hsu @pdhsu]

Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

[Maria Nattestad @marianattestad]

How to make this circos plot in 1 minute using Circa 2.0
https://t.co/mcSwjaEPEW

[Gregor Diensthuber @GDiensthuber]

VERY excited to share SeqTagger with the world! If you want to learn more about our super-fast and accurate demultiplexing tool for direct RNA-sequencing (DRS), check out the thread below. https://t.co/eJFT76dwwI (1/15) 🧵

[Ian Henderson @hendersi]

Amazing!

[Maria Nattestad @marianattestad]

Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using my tools Ribbon and SplitThreader:

https://t.co/AlF0gR17kA

[Astropierre @astropierre]

On dirait une forêt, mais il s'agit en réalité... d'un seul arbre de 47 000 troncs qui couvre une superficie de 42,6 hectares dans l'Utah 🇺🇸.

Son âge est estimé entre 16 000 et 80 000 ans, faisant de lui le plus vieil organisme vivants sur Terre

Source : https://t.co/63k1rMNNQb

[L'important @Limportant_fr]

Il y a quelques années, les voix des élèves de l'école de musique afghane résonnaient à Kaboul. Aujourd'hui, le silence règne. Les talibans ont fermé l'école, interdit la musique et interdit aux femmes et aux filles de chanter @HabibKhanT

[Eric Topol @EricTopol]

4 papers @Nature today on extrachromosomal (ec)DNA and cancer
—Present in 17% of cancers
—Suppresses the immune response
—Prognostic significance (figure)
https://t.co/6lmgNKHbB7
@CharlesSwanton and colleagues

[Nature Japan @NatureJapan]

Nature 2024年11月7日号 「外からの影響：染色体外DNAのがんへの影響を探る」

#ecDNA #がん治療 #nature

https://t.co/vv1NgOJNfV

[Rebecca Eccles @RLEccles]

Congrats @CancerGrand team eDyNAmiC- 3 papers in @Nature and ecDNA on the cover🥳

But how did we get here?!

Read more about how @mischellab @HowardYChang and @MariamJHanjani came to work on ecDNA, the incredible team and their findings

https://t.co/TjrFlVIOZ6

[Matt Jones @MattG_Jones]

Ecstatic to see our latest effort published in
@Nature! It's been a privilege co-leading this project with @kinglhung, @ivywtl, and EJ. We combined single-cell genomics, imaging, and evolutionary modeling to find that cooperative ecDNA species are co-inherited in mitosis.

[Chris Bailey @cbailey_58]

Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in @Nature

[Steven Artandi, MD, PhD @SCIDirector]

SCI members @HowardYChang & @mischellab found that 17.1% of tumors contained #ecDNA. ecDNA was > after targeted therapy or cytotoxic treatments. The presence of ecDNA was associated with metastasis & poorer overall survival. https://t.co/JywRHiFKQ2

[King L Hung @kinglhung]

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/

https://t.co/scC2sc61Gh

[Boundless Bio @BoundlessBio]

Three #ecDNA publications in Nature today - congrats @mischellab and @HowardYChang! One key paper highlights the importance of CHK1, a critical therapeutic vulnerability in ecDNA cancer, and the biological target of our lead program, BBI-355. More here: https://t.co/zqnbiFizT2

[Charles Swanton @CharlesSwanton]

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature https://t.co/TnMno4AZhU

[Anton Henssen @anton_gh]

Three papers and the cover of @Nature on ecDNA !!! 🔥🔥

What an amazing achievement by our @CancerGrand team eDyNAmiC led by @mischellab @HowardYChang @CharlesSwanton @MariamJHanjani @cbailey_58 @kinglhung and many more !!! 👏🏻👏🏻👏🏻👏🏻🍾🍾🍾🍾

Much more to come soon.

[Cancer Grand Challenges @CancerGrand]

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in
@Nature 📣

They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic.

More: https://t.co/lx5dtVlyDK

[Lorenzo de la Rica (he/him) @LdelaRica]

Also, let's take a moment to appreciate the beauty of this cover, which shows extrachromosomal DNA (ecDNA) next to chromosomes. ecDNAs are linked to therapy resistance and poorer outcomes for patients.
Credit: E. MacKenzie and J. Claus (@phospho) https://t.co/gkDdEDzsBX