Magnus Isaksson

Follow the data...

[Helix @my_helix]

We are honored to be one of the very first companies in the United States to have received access to the NovaSeq X+, the newest @illumina sequencer to date that we will be using for all of our viral and #DNA sequencing efforts. #technologyinnovator

[Helix @my_helix]

The Helix team was thrilled to see Dr. Dan Judge, principal investigator of In Our DNA SC, take to the podium at #ACC23 in New Orleans last week. Dr. Anwar Chahal from WellSpan was also in attendance to join the discussion on the role of screening in genetic cardiomyopathies.

[shishi luo @shishiluo]

The latest on reinfections from @my_helix:
- ~10% of total infections are reinfections
- ~2% of total reinfections are occurring within 90 days of the previous infection.

In chart, the denominator is total reinfections.

As always, thanks to @McCroneIV @robcrock

[shishi luo @shishiluo]

4/ There are many caveats and nuances. For full details, please check out our easy-to-read 4-page technical briefing https://t.co/4OoTN1QDik
Thanks: @alexbolze @McCroneIV @Maglaar

Also check out @KatherineJWu 's great write-up on this topic: https://t.co/MUVbY0r2OG.

[Helix @my_helix]

Register to hear Helix Staff Scientist, @alexbolze share our groundbreaking research on genetic susceptibilities to #COVID-19 vaccine side effects at the @GeneticsSociety Monthly Journal Club in June: https://t.co/ow91P5eM8x

[shishi luo @shishiluo]

As always thank you to the team at @my_helix @alexbolze @Maglaar for driving this work. I look forward to a day we can monitor all these viruses as well as, if not better than, we do SARS-CoV-2.

[Kelly Schiabor Barrett @kellyschiabor]

Interested in combining clinical data and population genomics? Find @genesareclever at #IS22… we’re hiring @my_helix !!

[Alexandre Bolze @alexbolze]

Curious about Delta-Omicron recombinants?

Our study 👏 @shishiluo @my_helix: https://t.co/psFMnqndvI

Co-circultation of both variants
20 samples with co-infections
Evidence of a few recombinations in co-infections
& 2 infections with 100% recombinant

Details in 🧵

[shishi luo @shishiluo]

The chatter about Omicron subvariants BA.1, BA.1.1, and BA.2 made me curious how well @my_helix's assay covers mutations that distinguish them.
Thank you @Maglaar for making this data so easy to query and @nextstrain's nextclade cli for the annotations.

[Alexandre Bolze @alexbolze]

Is BA.2 going to take over in the US ?

So far, BA.2 is still <0.5% of sequences in @my_helix surveillance. Not growing in last 10 days.

23 Jan (collection date): 2 BA.2 out of 215 seq
24 Jan: 6 / 556
25 Jan: 3 / 344
26 Jan: 0 / 434
27 Jan: 0 / 225

https://t.co/mltTLhk271

[Duke Precision Medicine Program @DukePreciseMed]

Coming up next week...

Join us on Thurs., Feb. 10 at 12 p.m. EST for our next Genomic & Precision Medicine Forum featuring Liz Cirulli, PhD (@ETCirulli) from @my_helix

Register in Advance: https://t.co/q8kI2MfIrD

[Alexandre Bolze @alexbolze]

Some discussions about BA.2 recently (see 🧵). Do we see BA.2 in @my_helix surveillance?

Dashboard now shows B.1.1.529, BA.1 & BA.2

Out of 3,801 samples collected in 2022 & sequenced: only 3 BA.2.
1 in CA, 1 in FL, 1 in LA

https://t.co/mltTLhk271

[Rick Bright @RickABright]

Impressive work @alexbolze and team @my_helix. 6 day turn around from sample collection to sequence publication & sharing is impressive. @PPI_Insights

[Alexandre Bolze @alexbolze]

Latest @my_helix sequencing:

Omicron: 97% for samples collected on January 9 (n=170)

Delta: hanging at ~3%

Similar to results from @NathanGrubaugh & @pavitrarc in US.

source: https://t.co/mltTLhk271

[Alexandre Bolze @alexbolze]

Again takes many teams to have 6 days between sample collection -> diagnostic test -> sequencing -> analysis to results on dashboard

Thanks @sustain_SCM ops team, @Maglaar @shishiluo bioinfo team

& external support + discussions to keep improving
@dmaccannell @RickABright

[Human Genetics and Genomics Advances @HGGAdvances]

New! @ETCirulli & colleagues identify an HLA allele associated with side effects from the Pfizer #COVID19 vaccine https://t.co/dD7qJzoRJk
#OA @GeneticsSociety

[Helix @my_helix]

Help our nation continue the fight against #COVID by working in Helix’s San Diego lab. We offer both referral and sign-on bonuses and are actively #hiring.

Specimen Handler: https://t.co/Se7o9K0nSO
Clinical Lab Technician: https://t.co/xvkyZUwKRh

[Liz Cirulli @ETCirulli]

So excited to have our study out on @medrxivpreprint showing that people with HLA-A*03:01 are twice as likely to get fevers and chills after Pfizer-BioNTech vaccination compared to those without this HLA type @alexbolze @my_helix @HealthyNV @grzymski @genesareclever

[Helix @my_helix]

New rare variant data published by Helix researchers in @GIMJournal shows the inclusion of 4 novel conditions, all actionable with >30% penetrance, may broaden the impact of population genetic screening, identifying 27% more at-risk participants: https://t.co/X4WgJPmf64