Marc Cohen

Biotech and Software entrepreneur, CEO, and Chairman.

[Marc Cohen @MarcACohen]

Check out the newest issue of the Degrader Digest where we highlight an upcoming #TPD conference with @HansonWade and other scientific and industry highlights: https://t.co/6BEHr235TH

[Marc Cohen @MarcACohen]

A new @MooreLab preprint paper describes the use of a cyclic coordinate descent algorithm to construct the energy landscape of PROTAC-mediated protein-protein interactions, opening up the possibility of adding design capabilities to #proteindegradation. https://t.co/VhGragQ4A4

[Marc Cohen @MarcACohen]

#ICYMI A recent @ACSMedChemLett article concludes that while N-acyl-N-alkylsulfonamide (NASA) chemistry can be used to selectively label proteins, the lack of #proteindegradation observed indicates that efficiency of this strategy remains an open question. https://t.co/p1FtKzOohL

[Marc Cohen @MarcACohen]

A comprehensive overview of opportunities and challenges in developing #proteindegradation therapies published in @ElsevierConnect Drug Discovery Today by @ianchurcher2 and colleagues.https://t.co/EtrNYzb4CZ

[Marc Cohen @MarcACohen]

A new @nchembio study from the @DASpiegel256 lab presents evidence that bifunctional synthetic molecules called MoDE-As (molecular degraders of extracellular proteins through ASGPR) can enable targeted #proteindegradation of extracellular proteins. https://t.co/txTSRaNybb

[Marc Cohen @MarcACohen]

If you haven’t, check out the newest issue of the Degrader Digest where we highlight new companies in the space, additional biology animations, and an updated list of industry events. We also include recent media articles and scientific papers: https://t.co/P9aHz3E7vz

[Marc Cohen @MarcACohen]

A recent paper published in @rsc_medchem describes generation and characterization of cereblon (CRBN) degraders as tools suitable for cell-based studies in CRBN biology and #proteindegradation drug discovery. https://t.co/Z2jqlUFDjT

[Marc Cohen @MarcACohen]

Assessment of #proteindegradation efficacy requires measurement of protein levels in cells: the @fischerlab1 recently published these protocols on how to quantify cellular protein levels and the corresponding tools for analyzing the data. https://t.co/B9WYwAR576

[Marc Cohen @MarcACohen]

This new @BiochemistryACS paper from the Nomura lab at @UCBerkeley reviews existing E3 ligases successfully exploited for targeted #proteindegradation and discusses strategies for discovering additional E3 ligase recruiters. https://t.co/6DFtst9LWf

[Marc Cohen @MarcACohen]

This new paper from @AndyMartinLab available on @bioRxiv describes how ubiquitin chains modulate 26S proteasome conformation to ensure substrate selectivity and prioritization in the cell during #proteindegradation.https://t.co/zJYiB9cQAD

[Marc Cohen @MarcACohen]

LYTACs (lysosome-targeting chimeras) are #proteindegradation tools that make use of the lysosome degradation pathway. This @ChemMedChem paper covers 2 studies that describe the scope of LYTACs and compare this tool with other #proteindegradation platforms https://t.co/a9NQ3I28y6

[Marc Cohen @MarcACohen]

In a recent #JMedChem article, authors share their perspective on the recent advances in molecular glues for targeted #proteindegradation & discuss challenges in developing molecular glues into therapeutic agents. https://t.co/jWFil0x35I

[Marc Cohen @MarcACohen]

PROTACs consist of a target binding unit, a linker & an E3 ligase binding moiety. A new @FrontChemistry review compares different synthetic opportunities to connect E3 ligands & describes the chemistry of linker attachment. https://t.co/zPpgKzP3vp

[Marc Cohen @MarcACohen]

The authors of a recent #JMedChem article from Eric Fischer’s lab @DanaFarber describe a newly developed bromodomain #proteindegradation tag along with the corresponding cereblon (CRBN)-based heterobifunctional degrader. https://t.co/pBxwrMdx4Y

[Marc Cohen @MarcACohen]

New @NatRevDrugDisc paper from @emblebi leader Andrew Leach’s team presents a systematic approach to assess the PROTAC tractability of protein targets, including novel targets not previously described in literature for future #proteindegradation efforts. https://t.co/XHnLS0fGLa

[Marc Cohen @MarcACohen]

Join the @KisakoRes European Degradation Congress on September 21-23 learn about advancements in #proteindegradation field. Register here: https://t.co/6UDasEUKa6

[Marc Cohen @MarcACohen]

Join the #DegraderDigest (https://t.co/dkTDzENUy6) to receive the latest issues, science & media updates, and industry events on #proteindegradation: https://t.co/QdoQYHwXYu

[Marc Cohen @MarcACohen]

The 3rd issue of the Degrader Digest is now live! https://t.co/dkTDzENUy6 This issue is your all-in-one place to learn about #proteindegradation and keep up-to-date on the most recent events and news. Join us to advance the cause!

[Marc Cohen @MarcACohen]

Want to be notified when a new issue of the Degrader Digest is released? Sign up with the following link and we will deliver the next release right into your inbox! https://t.co/BCO0tcq5JK

[Marc Cohen @MarcACohen]

A review published in @ELSpharma’s Current Opinion in Pharmacology discusses a ‘toolbox’ of assays, guidelines, reagents, and technologies to support #proteindegradation research and development in #oncology. https://t.co/ItZ8Zl6UQq