Mattia Privitera

Neuroscience. Locus Coeruleus and Noradrenaline.

[Nature Neuroscience @NatureNeuro]

During moderate tonic locus coeruleus activation in mice, noradrenaline release engages cortical regions related to associative processing, while burst-like stimulation biases the brain toward sensory processing

https://t.co/UkRCPJsqHv

[Peter Rupprecht @ptrrupprecht]

Out now in @NatureNeuro: "Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus", https://t.co/XkwuepGe8R
With a great team: @FritjofHelmchen @BohacekLab @SianDuss @cloois and (twitterless) Denise Becker. 1/5

[Johannes Bohacek @BohacekLab]

🔵 Noradrenaline directly regulates gene expression in the brain. 8 years in the making, now finally published in @eLife 🥳
During revisions, we added 32 RNAseq samples and a meta-analysis of 71 RNAseqs to rule out major sex differences. #stress
Please RT
https://t.co/80PCFtX44Y

[Katharina Gapp @GappKatharina]

I am not on instagram but thanks to @SRF our PROTAC is @BohacekLab @MGazorpak @CarreiraGroup @bel_ethz @MiriamKretschm2 @SelinaJoyFrei
@iivanova0541
@MattiaPri https://t.co/1uqATS8vmO
https://t.co/eXVD3JpdWC

[allen institute @AllenInstitute]

The first cellular map of a mammalian brain is here. 🧠✨

Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity.

Dive deeper: https://t.co/CXEIXooOVu

@nature #studyBRAIN #BICCN

[Mara Mather @MaraMather]

A new review paper led by @mj_dahl, Agnieszka Kulesza and @WB_Markus. We review how deficient #dopaminergic and #noradrenergic modulation of hippocampal plasticity may contribute to memory loss in aging and Alzheimer's disease https://t.co/RnIT0PVCp3 #locuscoeruleus

[Gianluigi Buffon @gianluigibuffon]

That's all folks!
You gave me everything.
I gave you everything.
We did it together.

[Johannes Bohacek @BohacekLab]

🚨In our latest preprint🚨 we propose a radical change to the analysis of rodent #behavior in preclinical research.

Featuring @DeepLabCut ♥️

Check out the manuscript and the 🧵👇
https://t.co/7gEbIpRR3a

[Mattia Privitera @MattiaPri]

@Cate_cholamine @BohacekLab @walkerdm79 Finally! If I only knew, i would have come to canada haha

[Katharina Gapp @GappKatharina]

1st preprint of the Gapplab! Check out our PROTAC tool to mingle with stress hormone receptor signalling A fun collaborative effort by @Carreiralab @BohacekLab @bel_ethz @Meijer_Lab @GermainPl
Lead by stellar students @MGazorpak & Karina Hungentobler https://t.co/JJCwquLQ1g

[Mattia Privitera @MattiaPri]

@MathiasVSchmidt @BohacekLab To expand on johannes's answer, the literature indicates that our target genes seem to be regulated by cAMP and consecutive CREB activation.

[Johannes Bohacek @BohacekLab]

🔵 In 2016 I wrote a grant, in which @MattiaPri and I asked a simple question:

Stress triggers massive transcriptional changes, which of them are dependent on noradrenaline (NA) signaling?

Today, we have the answer. But boy was this a journey. 🧵👇
https://t.co/vdXMagEjfm

[Itai Yanai @ItaiYanai]

New Nature paper provides evidence that science has become less innovative since the 1950s. The authors suggest reversing the trend by:
1. reading widely,
2. focusing less on quantity of papers, & more on research quality,
3. taking year-long sabbaticals.
https://t.co/oYV5JCXRl8

[ETH Zurich @ETH_en]

For the first time, farmers in the #Philippines have cultivated #GoldenRice on a larger scale and harvested almost 70 tonnes of grains this October.This nearly never-​ending story began at ETH Zurich. #betacarotene #vitaminA #HiddenHunger https://t.co/cBwCfhQSMi

[bioRxiv Neuroscience @biorxiv_neursci]

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics https://t.co/YIbBkEvrOl #biorxiv_neursci

[bioRxiv Neuroscience @biorxiv_neursci]

The locus coeruleus mediates behavioral flexibility https://t.co/AvYAir7QLc #biorxiv_neursci

[bioRxiv Neuroscience @biorxiv_neursci]

Locus Coeruleus firing patterns selectively modulate brain activity and dynamics https://t.co/cuubm4eJDg #biorxiv_neursci

[Valerio Zerbi @Valerio_Zerbi]

NEW PREPRINT FROM THE LAB📢📢: Locus Coeruleus firing patterns selectively modulate brain activity and dynamics! 3y in the making and this work is finally seeing light thanks to a fantastic teamwork! C Grimm, S Duss and @BohacekLab. Short thread ⬇️ https://t.co/ldeBmMAQb5

[Nelson Totah @NelsonTotah]

Very happy to share my lab’s new paper out in @PNAS. https://t.co/DkxRAYmd0T