Our latest preprint finds that a shortage of beneficial mutations does more to drive small populations extinct than mutational meltdown does. Explainers elsewhere @MawassWalid@JosephMatheson2@Uliseshmc@JeremyJBerg https://t.co/iTaneJEeRI
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@JosephMatheson2@arguablywrong@gcochran99@cremieuxrecueil ...instead of increase in fixation of deleterious mutations (i.e. mutational meltdown). We found that it mostly depends on the mean of the DFE of the beneficial mutations. We are also looking into running sims with pops crashing from 10K to 1K for ex.
@JosephMatheson2@arguablywrong@gcochran99@cremieuxrecueil Yeah, I've been looking at the case in small population sizes, so less < 10k. I do find evidence that there are realistic regimes where a decreasing population is driven into a mutation-driven extinction vortex due to a shortage of beneficial (compensatory) mutations...
@vsbuffalo Good thread Vince! As you've said, a correlation that varies with genetic relatedness is not evidence of genetic cause given that this correlation can be both transient and do some environmental or demographic processes. Plus, testing non-genetic models for fit with data matters.
Hi community, reaching out for help. At @GeneticsGSA ECLP, we're onto something (curtain-raiser soon!)
Plz tell us abt your favorite scientist (academia/industry) who is an inspiring leader. Someone who could spill secrets of leadership for community
Tag them here/DM me
RT plz