Meghamsh Teja

PhD @ Colm Cunninghams lab
Trinity Biomedical Sciences Institute

[Meghamsh Teja @MeghamshTeja]

Gpt5.6 is really good. I have active projects running.
1) server based mouse colony manager with rich features
2) lab notebook that backs up daily notes and can with on desktop and mobile
3) Aoe2 online hot key editor.
4) snack bar app that lets small business manage expenses

[Science Magazine @ScienceMagazine]

New experiments identify a receptor that helps regenerate the brain’s white matter after #stroke—and reveal that activating this receptor enhances cognitive and motor recovery in mice by stimulating “clean up” cells called microglia. @SciSignal https://t.co/OlZKxipfbA

[Ryuta Koyama @ryuta_koyama]

Our review is now online.

Bidirectional interactions between temperature and microglia: Implications for brain function and disease

https://t.co/CgBGC9q8js

[Neuropsychopharmacology @npp_journal]

This study identified a sex-dependent cannabinoid-microglia interaction in fear memory processing, suggesting that THC disrupts traumatic memory reconsolidation through sex-specific cellular mechanisms

https://t.co/mnpInWTrvh

[Martin Borch Jensen @MartinBJensen]

OK quick take on the brain microglia paper from @juliabelk @jaiswalmdphd & co.

The most important finding is that a significant fraction of brain microglia arise from bone marrow, updating the view from Ajami 2007 that it's all local brain self-renewal.

Their estimate of ~28% across 20 humans is rough, but the important thing is >>0%.

[Amanda McQuade @AmandaKMcQuade]

I'm excited to announce that our study, Transcriptional regulation of disease-relevant microglial activation programs, has been published this morning in Neuron: https://t.co/uvEea95LV8. We discovered functional regulators of six microglia activation states!

[hiyaaghosh @hiyaa_ghosh]

Meet the Lab | Hiyaa Ghosh | NCBS https://t.co/NlysIWA8y5 via @YouTube

[Dr. Uke @DrUkeAging]

Where do aging-related changes emerge in the brain?

A new @NatureAging study identified a population of microglia (the brain’s immune cells) that appears specifically in old mice and carries signatures of both cellular senescence and disease-associated inflammation.

These cells were concentrated in white matter, particularly the fimbria near the hippocampus. Targeting p16-expressing cells or BCL2 reduced this microglial population and partially restored a more youthful cellular organization.

The study did not test cognition, but it suggests that some aging-related changes in the brain arise in specific anatomical niches and may be partially reversible.
https://t.co/9W7YQh7pUO

[ZhuangLab @ZhuangLab]

Excited to share our recent paper (https://t.co/B7ZpR8Onv9)! In this multi-year effort, we developed RT&T-AMP-MERFISH, enabling whole-transcriptome-scale, isoform-resolved single-cell spatial transcriptomics and imaging ~33,000 RNAs in the brain.

[John Lukens @LukensJohnR]

Microglia prune developing cortical blood vessels through PD-1 signaling
https://t.co/9nHCYNxRl8 @NatureNeuro

[Colm Cunningham @Cunningham_Colm]

Thrilled to have our paper with @markcnewry out in BRAIN. https://t.co/jg6O7IZzcT We show that CSF1R inhibition to deplete proliferating microglia in APP/PS1 mouse model of Alzheimer's actually increases hyper excitability in hippocampal circuits https://t.co/MSdZTrTI2q

[Meghamsh Teja @MeghamshTeja]

@thsottiaux Could you please fix Android mobile app ? Remote here is not working as expected.
1) no pinned chats
2) takes a while to load conversation.
3) small QOL change would be to go back to side bar when we swipe back instead of closing the ap. few remote chat are not showing in app

[Ryuta Koyama @ryuta_koyama]

Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter

https://t.co/M5WG4db9xv

[John Lukens @LukensJohnR]

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain @ScienceMagazine https://t.co/OZoKApeIeF

[María A. Moro @MariAngelesMoro]

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease | Nature Metabolism https://t.co/GX98AdKWtZ

[María A. Moro @MariAngelesMoro]

Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke: Cell Metabolism https://t.co/DN65WwXcmF

[Meghamsh Teja @MeghamshTeja]

Absolutely loving gpt live. Feels like I'm talking to an intelligent human. Remembers conversations that happened at the start. Still not as good as general research with chatgpt but the future holds good promise. Absolute fun to just discuss thoughts that come to mind. #gptlive

[Ryuta Koyama @ryuta_koyama]

Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke: Cell Metabolism https://t.co/2wGNAs66Pu

[Rosa Paolicelli @rosa_paolicelli]

Our work on #Microglia and #TDP-43 in early #brain development is finally out @NatureNeuro! Congrats to the brilliant @AnneCompagnion and thanks to the many collaborators!!! Enjoy the read!! :) https://t.co/cj3NzeB3fz

[nature @Nature]

As neurons migrate to their final destinations in the forming brain, their DNA gets damaged. The brain has evolved a fix

https://t.co/CYPAdGU7Kr