Guilhem Kuczynski

Just out loud thoughts.

[Guilhem Kuczynski @Mehliu]

The problem with the energy consumption analysis we do cross industries / across society is that we never take into account the energetic cost of misattributed human labor.

🧵/10

[slash1s @slash1sol]

THE ENGINE DIRECTOR BEHIND AAA CONSOLE GAMES WALKED ON STAGE AT A C++ CONFERENCE AND TOLD A ROOM OF EXPERTS THAT THE CLEAN, OBJECT ORIENTED CODE THEY ARE PROUD OF IS A LIE AND IT QUIETLY THROWS AWAY 90% OF THE MACHINE THEY PAID FOR

85 minutes from Mike Acton -- engine director at Insomniac Games, where wasting cycles is not an abstract debate, it is the difference between a game that ships and one that dies.

-> His first principle is blunt: the only purpose of any program is to transform data. Not to model the world in pretty classes. Move data, fast.

06:33 -- The lie he calls out: "Software is the platform". No. The hardware is the platform. Ignore it and you cannot even reason about the cost of your own code.

Most devs never look at what the CPU actually does. They stack abstractions until the machine spends its life waiting on memory it should never have touched.

49:38 -- He prints a value, zips it, and measures the waste directly. A brutal little trick that exposes how much of your data is pure noise.

And this is the AI era's blind spot too. Agents generate more abstract code faster, on hardware nobody profiles, while the GPU bill quietly explodes.

You thought clean code was the goal. This is the man shipping real engines saying the machine is the goal, and clean code is often how you lose it.

Bookmark it & you'll never look at your own abstractions the same ↓

[Fred Scharmen @sevensixfive]

Still unnaturally obsessed with this cursed image I spent five minutes making in 2023

[Bryan Johnson @bryan_johnson]

This is exciting...5-MeO-DMT just got FDA breakthrough designation for treatment resistant depression.

193 ppl with moderate-to-severe depression
38 sites
6 countries

Patients received either 12 mg (n=73), 8 mg (n=46), or a low-dose comparator of 0.3 mg (n=74), which served as a placebo control.

Efficacy Findings
+ at day 29 post-dosing, a single 12 mg dose reduced depression scores by 11.1 points (MADRS scale 0-60), compared to a 5.8-point reduction with the low 0.3 mg dose.
+ the 8 mg dose demonstrated equivalent efficacy, suggesting its potential sufficiency for therapeutic benefit.
+ effects of both 12 mg and 8 mg therapeutic doses were statistically significant compared to the low 0.3 mg dose, starting two days after treatment and peaking at 29 days post-treatment.
+ both 12 mg and 8 mg single doses exhibited durable effects, with mean depression score reductions of 10.2 and 10.8 points, respectively. Both were significantly greater than the 5.2-point reduction observed with the low 0.3 mg dose.

Safety Findings
+ 5-MeO-DMT was well tolerated at all doses, with over 99% of adverse effects being mild or moderate and no serious adverse effects reported.
+ dose related increases in nausea, headache, blood pressure, and anxiety suggest the 8 mg dose was better tolerated than the 12 mg dose.
+ no suicide-related safety signals or concerns were observed.
+ most treated patients were deemed ready to go home within 90 minutes of treatment

Findings from the phase 2a open-label study, using 12 mg and 8 mg doses spaced two weeks apart, showed similar results. These included a rapid decrease in depression score by day 2, maximal improvement at day 22, with a durable effect lasting over 12 weeks of follow-up.

[Guilhem Kuczynski @Mehliu]

@feanor_legend @chickengenius Trump wants a weak dollar to export and reindustrialise the US

[Guilhem Kuczynski @Mehliu]

@hubermanlab It's just an American thing

[Guilhem Kuczynski @Mehliu]

@UnoptimizedBird Not the point. Love yourself first don't compare.

[Guilhem Kuczynski @Mehliu]

@Kveldred @Frakon @iamyesyouareno Lmao no there isn't, africa is the most culturally diverse piece of land in the world by very very far.

[Guilhem Kuczynski @Mehliu]

@bryan_johnson If it pays for the food

[Guilhem Kuczynski @Mehliu]

Creativity is nothing more than the deep integration of abstractions.

[Guilhem Kuczynski @Mehliu]

@atahan_game_dev Most powerful lobby in america

[Guilhem Kuczynski @Mehliu]

@atahan_game_dev idk I just randomly do everything in any order, but surely some people are more difficult and rigid than others with this.

[Guilhem Kuczynski @Mehliu]

@_dirtyiron_ I've been trying to reach out to you but it's a little hard with socials like twitter

[Guilhem Kuczynski @Mehliu]

@Alariko_ if you're used to cameras in any measure you can't possibly see gold. Cameras don't behave like that.

[Guilhem Kuczynski @Mehliu]

@pyquantnews I say "Valar Morghulis" and thus they realize the probability is indeed zero. (You never said when)

[Guilhem Kuczynski @Mehliu]

@premium here's a question how do you cancel your twitter subscription if you are on the basic tier ? You can't even DM support in that position

[Guilhem Kuczynski @Mehliu]

@Lscgrz @itsme_urstruly @gunsnrosesgirl3 I mean people don't get born with the exact same tint of pink hair

[Guilhem Kuczynski @Mehliu]

Very nice thread

[Bob Elliott @BobEUnlimited]

The benefits to S&P500 companies from rising AI-related spending and increased economy-wide productivity are modest even in an extremely optimistic case.

Thread.

[Guilhem Kuczynski @Mehliu]

@TradersMastery @RodfTutor @willywoo Remember don't base reasoning on a single tangent of yours. Take the data without your added noise. Invert the analysis, ask yourself why so much data is collected at airports first and foremost. It's a very simple answer.

[Guilhem Kuczynski @Mehliu]

@PaulBerick @KastleCapital @chickengenius I think I'm still missing part of the story. I just remember him supporting the charity. Did his adopted dog die ?