Michael Hadler

Neuroscience | Researcher @Charité Berlin
Interneurons, high-frequency oscillations & the microcircuit of neuropsychiatry

[Trends in Pharmacological Sciences @TrendsinPharma]

Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues https://t.co/yFz1R5I4Cb

[Michael Hadler @MichaelDHadler]

Here it is! Can memory deficits in Alzheimer's and schizophrenia be treated by mixing PV interneurons, mGlur5, neuropeptides and gamma oscillations?
Check out our Opinion piece in @TrendsinPharma out now 👋
Thank you IN-CODE (@bartos_marlene) for funding!
https://t.co/nlSlAPxu5M

[Michael Hadler @MichaelDHadler]

@martin_a_vinck @ScienceAdvances @TrendsNeuro @TheCraigLab Definitely, love it!

[Michael Hadler @MichaelDHadler]

Extremely flattered to have our @ScienceAdvances paper mentioned in @TrendsNeuro by interneuron & oscillation virtuosos @TheCraigLab!!
They discuss how gamma plasticity may interact with the peptide NPTX2 in health and disease. Indeed, someone should elaborate on that ... 🤔

[Yangfan Peng @YangfanPeng]

🧠 Curious about how neurons are wired in the human cortex?

Our @ScienceMagazine study tested over 7,000 connections and revealed key differences from rodents:
"Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit". 🧵👇https://t.co/yUeQjbDSh7

[Michael Hadler @MichaelDHadler]

@JWietek It was a joke and we all laughed about it, but yeah, definitely a badge of honor ;)

[Michael Hadler @MichaelDHadler]

Well, this is awkward … my paper is out in @ScienceAdvances! And everyone’s tweeting about it … except me … 🫣
Together with @ATzilivaki, we show “interesting data, primitive method” (real quote from real prof). But what’s it about?
Y’all read – me parental leave 👇👇👇

[Chini Mattia @chini_mattia]

Congrats!
Gamma oscillations, PV interneurons, plasticity.. what else could one want? This paper is awesome 🔥

[Michael Hadler @MichaelDHadler]

As he wasn't mentioned earlier: I would like to specifically thank x-less Henrik Alle for his immense contribution to this paper. Also, generous funding came from @Retune_CRC and the interneuron plasticity grant FOR2143 by @bartos_marlene

[Michael Hadler @MichaelDHadler]

Absolutely vital thread - read to the end. Sorry you went through that

[Yangfan Peng @YangfanPeng]

Excited to finally share our multipatch data with 964 patched human pyramidal neurons! 🥳 We identified functional subtypes in L2-3 that are preserved across patients! Have a look at our bioRxiv preprint https://t.co/e9jFR8XNeB and join our live poster session on Thursday 👇.

[Attila Losonczy @attila_losonczy]

Work led by a fantastic post-doc, Andres Grosmark in the lab on the role of hippocampal sharp wave ripples in long-term memory consolidation. https://t.co/oscrJYIMar

[Michael Hadler @MichaelDHadler]

Driving network oscillations beyond the theta frequency range disrupts memory encoding

[Nature Neuroscience @NatureNeuro]

Precisely timed theta oscillations are selectively required during the encoding phase of a spatial working #memory task

New from @IpshitaZ and colleagues

https://t.co/6ZCQsxjhep

[Ardem Patapoutian @ardemp]

A day to be thankful: this country gave me a chance with a great education and support for basic research. And for my labbies and collaborators for partnering with me. So glad @NancyAHong captured this "touching" moment. #PIEZO

[Scott @Havenlust]

Trees, 1961

Tomioka Soichiro

[Luise Lehmann @lehmalu]

Nicer #Klimastreik 🤗🌻🏳️‍🌈 Lasst mal jetzt Berlin klimaneutral machen bis 2030, so schnell wie möglich raus aus Kohle und Massentierhaltung und das 1,5°C-Ziel schaffen. Okay?

[Michael Hadler @MichaelDHadler]

So this is an amazingly fascinating topic with a lot if potential: How do ionotropic and electronic transmission in interneurons cooperate during states of increased activity? Also in interneurons, function follows form - we often forget about this. Also, check out the paper ^^

[Neuralynx @Neuralynx]

Optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2–/– mice, similar to NMDAR-dependent social rescue. NMDARs and gap junctions cooperate to promote social cognition. #Autism #neuroscience #openaccess
https://t.co/e5YKvPYtWC

[Michael Hadler @MichaelDHadler]

And a great response thread! However, t-SNEs and similar are disturbingly over-used imho and should only be implemented by experts in hypothesis generation/evaluation

[Tim Sainburg @tim_sainburg]

There's a new preprint calling to stop using UMAP, t-SNE et al, calling them arbitrary "Specious Art", which I disagree with. It's getting a lot of attention, and I think I have an idea why.

[Luise Lehmann @lehmalu]

Warum Steuersenkungen per sé Mist sind, geförderte Investitionen sich aber lohnen - Danke @ThomasFricke10!
https://t.co/wLkHZNyMyB

[Michael Hadler @MichaelDHadler]

@thejenjay Frankly I never cared about cutting as long as it's not outlandish only thing that matters is recovery and that's where you make the big bucks

[Jennifer Jahncke @thejenjay]

POV: You're a membrane protein sitting on the surface of a cortical pyramidal cell.