Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! https://t.co/bbuuJJnkWF
Out today from the Blanchard lab! An important paper showing that the accuracy of smFRET measurements depends on excitation strength, and how to correct for these issues or bypass them with self-healing dyes. https://t.co/2dpO9NU5lE
It is out in @PNASNews. A massive bioinformatics undertaking by @gem__atkinson lab + an insane amount of experiments from my team and numerous collaborators. The first new phage defence system from Lund! @HenrikStrahl @arneelof@KarinErnits@FacultyLund https://t.co/x6cH8Upbfx
Happy to share that Mathew Gagnon and my lab's joint story of translation inhibition by aminoglycoside Amikacin is now published in @NatureComms 🥳🥳🥳. Superhappy for this collaboration. Fast-kinetics biochemistry and structure together make a very powerful tool afterall 😃
Our study shows that ribosomal genes—widely used to infer the origin of species—also hold a record of the optimal growth conditions for a given species, making it easier to infer the optimal environment for uncultured or extinct organisms (1/3): https://t.co/kWLU8vpcQe
We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇
Very soon and thanks to one an only @delarosatrevin an integrated solution for CryoEM facility management and on-the-fly processing with Cryolo/ctfffind/Relion ! And free!!! 👇🏽
Look at these gorgeous ribosome from @TheBlanchardLab !
Happy to anounce our paper published today @Nature - a tour-de-force in tRNA biology. We developed suppressor tRNAs with high efficieny in correcting PTCs. For a disease protein we crossed a disease threshold of correction. #cftr#uhh https://t.co/sr0CHUlIMJ
Proud to be involved in this work. Please have a look. High res.80S ribosome, many states, interesting story.
@TheBlanchardLab@AlexmagCryo@KundhavaiS
https://t.co/c5Ug92JjvZ
Now #OA@Nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, @TheBlanchardLab reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors.
https://t.co/rMVrLUg5o9
Human ribosomes decode messenger RNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how St. Jude scientists made this discovery. https://t.co/IhU9QII1sE @TheBlanchardLab@nature#cryoEM