Tomer Milo

Postdoc @ the Wong lab | MIT & Ragon Institute | Quantitative Systems Immunology

[Harikesh Wong @HarikeshWong]

Out today in @CellCellPress! We introduce “mesoscale modules”—recurring multicellular functional units that provide a bridge between the behaviours of individual cells and the emergent properties of tissues.
https://t.co/ZxcP09M1ep

@ragoninstitute @MITBiology

[Weizmann Institute @WeizmannScience]

אנחנו נמצאים בנקודת זמן קריטית לשיקום מכון ויצמן למדע, וזקוקים לתמיכה שלך.
בעזרתך נוכל לבנות מחדש מעבדות, לבסס מחדש מחקרים פורצי דרך ולהוביל את המדע לגבהים חדשים. התרומה שלך היום תניע את התגליות של מחר. עכשיו זה הזמן. לתמיכה >&gtאנחנו נמצאים בנקודת זמן קריטית לשיקום מכון ויצמן למדע, וזקוקים לתמיכה שלך.
בעזרתך נוכל לבנות מחדש מעבדות, לבסס מחדש מחקרים פורצי דרך ולהוביל את המדע לגבהים חדשים. התרומה שלך היום תניע את התגליות של מחר. עכשיו זה הזמן. לתמיכה >&gtאנחנו נמצאים בנקודת זמן קריטית לשיקום מכון ויצמן למדע, וזקוקים לתמיכה שלך.
בעזרתך נוכל לבנות מחדש מעבדות, לבסס מחדש מחקרים פורצי דרך ולהוביל את המדע לגבהים חדשים. התרומה שלך היום תניע את התגליות של מחר. עכשיו זה הזמן. לתמיכה >&gtאנחנו נמצאים בנקודת זמן קריטית לשיקום מכון ויצמן למדע, וזקוקים לתמיכה שלך.
בעזרתך נוכל לבנות מחדש מעבדות, לבסס מחדש מחקרים פורצי דרך ולהוביל את המדע לגבהים חדשים. התרומה שלך היום תניע את התגליות של מחר. עכשיו זה הזמן. לתמיכה >>

[Weizmann Institute @WeizmannScience]

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[Tomer Milo @MiloTomer]

@HarikeshWong Thanks Hari for your mentorship. You had a significant contribution to that achievement.

[Tomer Milo @MiloTomer]

I'm proud to pursue my research under @HarikeshWong's guidance in the inspiring environment of the @ragoninstitute.

#JCCFellow

[Ragon Institute @ragoninstitute]

Congratulations to Tomer Milo, PhD, a postdoctoral fellow in the Wong Lab at the Ragon Institute, who was recently awarded a prestigious Jane Coffin Childs Fellowship!

https://t.co/Ch5PMNVwpO

#JCCFellow #RagonInstitute #Immunology #JaneCoffinChildsFellowship

[Harikesh Wong @HarikeshWong]

Out today in @ScienceMagazine! We show that rising self-antigen levels during infection give self-reactive T cells an opportunity for enhanced TCR signalling. Regulatory T cells of matched specificity counteract this, thereby preventing autoimmunity. https://t.co/qtPMsBG4A1

[Tomer Milo @MiloTomer]

Incredible work! Congratulations Shoval!

[Shoval Miyara @MiyaraShoval]

It’s finally here! My PhD work, five years in the making, is now published in @CellSystems🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. 🧵
https://t.co/2jAfKNBbKg

[Tomer Milo @MiloTomer]

@MiyaraShoval Thanks Shoval! 🙏

[Tomer Milo @MiloTomer]

Happy to see this out! Hoping our predictions prove correct and help guide new treatment directions for mood disorders. Thanks @MolSystBiol for highlighting our study!

[Mol Syst Biol @MolSystBiol]

@UriAlonWeizmann lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ https://t.co/Hl4PIDbNU6

[Tomer Milo @MiloTomer]

Together with @NirShiraz, @MoriyaRaz , Avi Mayo

[Tomer Milo @MiloTomer]

We think the ability of endocrine glands to adjust their mass might explain why several promising drugs that target cortisol, the stress hormone, fail in clinical trials for mood disorders. We propose a new target - CRH. Hormonal feedback circuits can be tricky. @UriAlonWeizmann

[bioRxiv SysBio @biorxiv_sysbio]

Hormone circuit analysis explains why most HPA drugs fail for mood disorders and predicts the few that work https://t.co/vqIPw5hNbG #biorxiv_sysbio

[Andreas Tiffeau-Mayer @andimscience]

Lightning-fast adaptive immune receptor similarity search by symmetric deletion lookup
https://t.co/3uqZF9AyMF

In work led by @heartnetkung we show how an algorithmic paradigm from spell checking can accelerate TCR clustering by orders of magnitude

[Tomer Milo @MiloTomer]

@omer_karin Congrats Omer!
Beautiful work

[Omer Karin @omer_karin]

Our theory paper on plasma cells is out. Protection following vaccination or infection depends to a large extent on the survival of plasma cells, but what determines their lifespan in the body?

https://t.co/Bej53SaDjA

[Uri Alon @UriAlonWeizmann]

We are now using the model to identify HPA drug targets to lower cortisol, see upcoming work by @MiloTomer

[Tomer Milo @MiloTomer]

Here we suggest that mood fluctuations in bipolar disorder is driven by cortisol slow (months-scale) dynamics.

It was a long journey of sharpening our premise and I am glad it is finally out :)

[Uri Alon @UriAlonWeizmann]

A new mechanism for bipolar disorder.
We measured hair cortisol over 12 months, and used large scale data on moods and our math model of the stress HPA axis, to propose how mood swings are generated.

#SystemsMedicine #ComputationalPsychiatry
https://t.co/P8dDJQ0nfU

[Uri Alon @UriAlonWeizmann]

E. coli engineered to become stem cells that differentiate! We prevent take-over by mutant stem cells that only self renew - by linking differentiation to an essential function. A new way to engineer stable microbial communities.
https://t.co/GW9XXWNYVg

[Miri Adler @MiriAdler]

Started my new position as a senior lecturer (Assistant Professor) at the Alexander Silberman Institute of Life Sciences and the Faculty of Medicine at @HebrewU.
We develop computational frameworks to study fundamental principles of tissues in both health and disease contexts.

[Uri Alon @UriAlonWeizmann]

Why do we get certain diseases whereas others do not exist?
This new book builds a foundation for systems medicine. Starting from basic laws, it derives why hormone, immune and aging circuits are built the way the are, culminating in a periodic table of diseases.

[Shaul Amsterdamski 🤞 @amsterdamski2]

This makes me sick to my stomach. Absolutely horrific