Minicircle

Plasmid gene therapy for health and wellness ❤️

[Minicircle @MinicircleDNA]

@AbudBakri Great history of BPC-157, the world's most popular peptide!

[Minicircle @MinicircleDNA]

Q: Why do Minicircle treatments last around 1 year?

Angelica Giuffre, Minicircle’s Research and Development Manager shares why Follistatin, which is injected into fat cells, delivers benefits for approx. one year.

Have other questions? Drop them into the comments below and our science team will answer them.

[Minicircle @MinicircleDNA]

@quintinfrerichs We were founded as a human enhancement company. 🙂
Gene therapies must be broadly available not just to treat or cure disease but to enhance the function and resilience of human consciousness.

[Parsifal Al-Nafis @rosicrucial]

Nothing tastes as good as reality feels.

[Minicircle @MinicircleDNA]

@p_maverick_b It’s very important not to ask them

[Minicircle @MinicircleDNA]

Congratulations @ADvantageTx @howardleonhardt and @KlothoNeuroSci for helping throw the best scientific research conference. @MinicircleDNA is a great supporter of Dr Makoto Kuro-o’s tireless and revolutionary work elucidating the mechanisms of this extraordinary gene.

[Minicircle @MinicircleDNA]

@lgngrvs @MichaelDmrks Scalable means widely distributable logistics and manufacturing, low cost of production, accessible pricing, low immunologic risk at point of administration.

[Patri Friedman 🌆 @patrissimo]

TLDR: The @MinicircleDNA follistatin gene therapy increased my VO2 max by as much in a week as 3 months of training.

I'm sharing this due to the doubt I've seen both from anti-tech media & my skeptical, well-intentioned friends like @yashgaroth & @s_r_constantin.

I'm not qualified to evaluate the science & I don't have N=many data, but I can speak as an N=1 who saw significant performance impact from this treatment @farbood, @bryan_johnson, @michaelmalice & others got at @ProsperaGlobal.

My first treatment was in 2023, and I was expecting mainly muscle growth effects. A week later, my cardio performance improved drastically, in a way that was both unexpected & subjectively unmistakeable: one day I was suddenly running almost 50% longer with the same effort. I later participated in their reversibility study to turn off the gene therapy, and of course afterwards I got the therapy again. The second time, I decided to collect VO2max data before, during, and after.

From the baseline first row, you can see that V02max increased by 4.8 ml/kg/min in 2 months of training; 4.3 in one week after the therapy, and another 3.6 in 3 months of training. These differences exceed the expected 2%-5% per-trial variation of 1-3 ml/kg/min.

I get the skepticism (it's a new treatment and there's little public data), and I think it's healthy to have doubt and pushback from those with high integrity like Max & Sarah (though I could do without the clickbait tech-hating MSM). But when I read things insisting this therapy can't do anything meaningful, I know from direct personal experience that this is simply not true.

I encourage anyone else doing this therapy to collect similar data and report back - my DMs are always open 🙏.

[Minicircle @MinicircleDNA]

Another reason to go to Cabo for your next vacation: Minicircle’s Follistatin is now available at Proactive Longevity, one of Mexico’s leaders for longevity treatments and comprehensive wellness solutions.

Learn more and book your appointment at https://t.co/8fUFqw1SbO.

[Minicircle @MinicircleDNA]

We’re lucky to have Ryan Rossner on our team as Chief Research Officer. As an athlete turned scientist, he brings a unique perspective to the longevity space — one that’s rooted in rigor and curiosity.

On the podcast @Wellpower last winter, Ryan shared about his background, work with Minicircle, and hopes for the future of biohacking and longevity. It’s worth a listen!

[Minicircle @MinicircleDNA]

RAADfest 2025, hosted by @RLECoalition, was a success! We had a great time in Vegas getting inspired and meeting with the longevity community. ♾️

It was particularly special to hear our CEO and Co-Founder Mac Davis as well as our Chief Revenue Officer Jay Spall share about our gene therapy technology and mission on the big stage. Thanks to everyone who stopped by our booth.

#RAADfest #longevity #biotech

[Minicircle @MinicircleDNA]

Ryan's episode of the Longevity Junky Podcast is now live!

Apple Podcasts: https://t.co/djobEtAyNw
Youtube: https://t.co/rNm6oHkK8l
Spotify: https://t.co/aP3hPpjfAg

https://t.co/T1yINIqSmV

[Longevity Junky @longevity_junky]

A safer approach that adds gene function without editing your genome.

Watch the full episode with NFL-player-turned-scientist, Dr. Ryan Rossner, on how hypoxia and gene therapy improve longevity:
https://t.co/2Wf45Ou4Of

#LongevityJunky #GeneTherapy #plasmid #genome

[Minicircle @MinicircleDNA]

@elonmusk every day

[Minicircle @MinicircleDNA]

🧬 Fascinating deep dive into plasmid gene therapy with our own @ryanjrossnerphd

Topics covered:

- How plasmids work
- Real human trial data: 2 lbs lean mass gain, 8% body fat reduction
- Effects estimated to last ~1 year

Worth watching if you're interested in the future of genetic medicine 👇

[ModernHealthspan @MHealthspan]

The future of muscle growth is here, and it's more accessible than you think! Our interview with Dr. Ryan Rossner of @Minicircle dives into Follistatin via plasmid technology. A massive thanks to Dr. Rossner for sharing this groundbreaking science!
https://t.co/6LPbcqqjzy

[Minicircle @MinicircleDNA]

@sighswoon soylent was lowkey goated

[Bryan Johnson @bryan_johnson]

Sleep increases your odds of success.

[Minicircle @MinicircleDNA]

@CarlisleDiana it’s the best place to build a radical health business 😎

[Shriya Bhat @ShriyaPBhat]

George Church is bullish on gene therapy for aging.

We target rare diseases, so by economies of scale, prices remain high.

But aging is the most common disease. Once we scale viral-vector factories like mRNA vaccine plants, per-dose costs could drop below a domestic flight.

[Minicircle @MinicircleDNA]

@PSSDNetwork @farbood @DrDavidHealy @christophlane great answer 🥹