VHL & PBRM1 are commonly co-inactivated in ccRCC. Our new preprint 🥳explores how these two lesions actually co-operate during tumorigenesis, using single-cell histology and transcriptomics in an in vivo ‘cell tagging’ model.
https://t.co/uFVHWM1rTh
🧵1/3
Excited to share our new paper out on @biorxivpreprint
We used oncogenic cell tagging🔬🐁to delineate the roles of HIF1 and HIF2 in the earliest events that follow VHL loss in the kidney
Our findings show a potential for HIF2 inhibition to stop renal cancer before it starts 😮
Cancers are often born decades before we can see them.
We wanted to know what happens in cancer-causing cells during this latent period of oncogenesis 🔍
Our new paper @CR_AACR explores this question for VHL-driven #KidneyCancer!
A🧵on what we learnt: 1/
https://t.co/k2J6oitYKb
On my way to my first ever #DiscoverBMB conference @ASBMB !
Super excited to be giving a spotlight talk in the Mitochondria Energetics/Metabolism Session !!
New in JBC press: "Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells."
Learn more:
https://t.co/622WG3nYQa
Happy to finally say that my first, first author paper is out at @jbiolchem!
Huge thanks to @VamsiMootha for his constant mentorship and support through this process and everyone in the Mootha Lab for making this possible! https://t.co/OYd8rps6jC