Ameya Kulkarni, PhD 👨‍🔬

Neuroscience, 🧬 Omics, and 🧠 Aging at @JNJInnovMed
🎓 @ChicagoBooth, @EinsteinMed, @NCState

[Sandra Aleksic MD @SandraAleksicMD]

#TopDownloadedArticle @AgingCell Top 10% among articles published in 2022. So happy to see the impact of our work @mr_genetics @NirBarzilaiMD @EinsteinMed @MontefioreEndo @EinsteinDeptMed
https://t.co/ngGGs2juAK

[Nir Barzilai @NirBarzilaiMD]

The FAST (Finding Aging biomarkers by Searching existing Trials) Initiative has received an @impetusgrants grant to support its aims of establishing biomarkers to advance development of biomarkers for clinical trials in aging. @Danbelsky and I are excited! https://t.co/plIVWMZSlq

[Premier League @premierleague]

Pulse pounding.

#ARSMUN

[ISRO @isro]

Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3

Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.

Congratulations, India🇮🇳!

#Chandrayaan_3
#Ch3

[PhD_Genie @PhD_Genie]

How a PhD looks like from a supervisor's perspective...

https://t.co/HrejAmoV7x

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

It was so fun to see this race to everyone’s favorite hypothesis for AD pathology in real-time at #AAIC22

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

Excited to be in San Diego for an in-person conference in a long time!! Looking forward to the next 5 days of world class research in Alzheimer’s and presenting our work on multiomics of tau progression from @abbvie!
#AAIC22 #ENDALZ

[Google DeepMind @GoogleDeepMind]

Today in partnership with @emblebi, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: https://t.co/GjVES2pBFY 1/

[NASA @NASA]

It's here–the deepest, sharpest infrared view of the universe to date: Webb's First Deep Field.

Previewed by @POTUS on July 11, it shows galaxies once invisible to us. The full set of @NASAWebb's first full-color images & data will be revealed July 12: https://t.co/63zxpNDi4I

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

@AFARorg @wakeforestmed @j_n_justice Congratulations Jamie @j_n_justice!! So well deserved!

[Eric Topol @EricTopol]

🆕 @NatureGenet
The discovery of 42 new genomic loci associated with Alzheimer's disease. Remarkable progress in the genomic underpinnings of the disease with nothing to show for an effective treatment yet
https://t.co/0KAfkHGKMy

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

@BrandonSLockey @AgingCell @SandraAleksicMD @george_kuchel @NirBarzilaiMD The ITP could not replicate mouse lifespan extension by metformin (0.1% w/w)- https://t.co/yciGcUFttx

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

Excited to share our work published in @AgingCell summarizing top FDA-approved drugs that can be repurposed as gerotherapeutics / geroprotectors

Amazing collaboration with @SandraAleksicMD, David Berger, Felipe Sierra, @george_kuchel and @NirBarzilaiMD

https://t.co/h5ANs7wedj

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

@agingdoc1 @SandraAleksicMD @george_kuchel @NirBarzilaiMD Thank you @agingdoc1 😄

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

Our scoring was based on clinical and preclinical evidence of ↑ healthspan indicators and ↓ mortality, as well as targeting the hallmarks of aging.
Top candidates- SGLT2 inhibitors and metformin

#aging #longevity #healthspan #geroscience #clinicaltrials #drugdiscovery #FDA

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

@vallens This is a very important point. I'd be curious to see how the number of donors varies between tissues of origin. Is it likely that most of the 100+ donor studies are with PBMCs?

[Chris Cannon @colourfulchris]

It’s my new favorite song.

[Nir Barzilai @NirBarzilaiMD]

Geroscientists often speak of “hallmarks of aging”. To become a hallmark, we need to show 1) it changes with aging and 2) fixing it (with any of a variety of tools e.g. genetics, drugs, nutrients) will improve both healthspan and life span in mammals (pre-clinical animal models).

[Ebony Watson @Ebony_rw]

Our new review has recently been published! https://t.co/N5bP4rxZ7q
Covering the current state of single-cell omics & imaging technologies, & computational methods to perform integrative analyses of these datatypes to discover new insights, with case-studies from #aging

[Ameya Kulkarni, PhD 👨‍🔬 @mr_genetics]

Thrilled to be a part of this collaboration!

[Christopher Fry @ChrisFryPhD]

Excited to share our recent findings showing a progressive fibrotic muscle phenotype in patients with CKD that is dialysis-responsive. Fantastic team effort!
https://t.co/luck4JtvW1 @JCI_insight @CBrightwellPhD @mr_genetics @UKYCMB @EinsteinMed @MonteNephrology