The Muir Lab

The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.

[The Muir Lab @MuirLab]

Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem

[Princeton Chemistry @PrincetonChem]

The @MuirLab’s Zoe Merz won the ACS Knowles Award for her abstract “Context Dependent Photocatalytic Proximity Reveals Interactors Unique to Receptor Combinations,” at the recent Bioorganic GRS+GRC.

Congratulations Zoe (right)! Also pictured below, Gen Li (center, Chang Lab).

[The Muir Lab @MuirLab]

https://t.co/MgcRk0bloT

[The Muir Lab @MuirLab]

Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem

[The Maze Lab @themazelab]

Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele

[Princeton Chemistry @PrincetonChem]

With a background in math and physics, Postdoc Jeremy Owen's the first-ever computational theorist hired into the @MuirLab. He investigates the “dizzying complexity” of chromatin.

Enjoy the first of our stories celebrating the postdocs of @PrincetonChem: https://t.co/fxFQQRaZlN

[Sid Jain @SiddhantUJain]

2/9. This work was a true teamwork. Huge congratulations to our collaborators at @kadochlab , @MuirLab , @GygiLab , Michael Gross (WashU). Special thanks to Kadoch lab members - @CKadoch, Dr. Kaylyn Williamson, @alex2110x, Aasha Turner, Maxwell Allison, Kevin So!

[Sid Jain @SiddhantUJain]

1/9. Happy 2026, everyone! We are excited to share our new study on how mSWI/SNF chromatin remodeling complexes interact with DNA sequence-specific Transcription Factors (TFs), out this week in Science! @ScienceMagazine
Doi: https://t.co/om7OoWJxh1

[Dr. Nicolas L. Young @NicolasLYoung]

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. https://t.co/WrMYTXamIe

[Princeton Chemistry @PrincetonChem]

Congratulations to our Tom Muir @MuirLab on being awarded the @AmerChemSociety's Ralph F. Hirschmann Award in Peptide Chemistry for exceptional achievement in the field. Well done, Tom!

Enjoy our story here: https://t.co/T26DeWQlFu

[The Muir Lab @MuirLab]

Congrats again to all our graduates!

[The Muir Lab @MuirLab]

With the start of the new academic year comes several farewells from our lab, as senior members of the lab graduate. First off, congratulations to our “transposein” Dr Yi Hua, who is heading off to @Stanford for a postdoc with @aliceyting

[The Muir Lab @MuirLab]

And last but not least, we have Dr Yingzi Huang, who presented a wonderful seminar on her chromatin within the context of DNA damage. Stay tuned for this story…

[Princeton Chemistry @PrincetonChem]

Congratulations @MuirLab postdoc Jason Johansen-Leete on his Life Sciences Research Foundation Fellowship, sponsored by Amgen, for his project: “High-resolution mapping of the BAF interactome with novel chemoproteomic technologies.”

Well done, Jason!

[The Muir Lab @MuirLab]

Congratulations to Tom for receiving the Ralph Hirschmann award in Peptide Chemistry! @PrincetonChem

https://t.co/HS2syixNKo

[nature @Nature]

Nature research paper: Programmable protein ligation on cell surfaces

https://t.co/sYlmpJYQpA

[Princeton Chemistry @PrincetonChem]

The @MuirLab introduces a groundbreaking protein activation platform that allows “exquisite precision,” in @Nature last week.

Enjoy our story on this @NIH funded research by Christian, Girum, Nicholas, Xuanjia, Yutong and Tom:

https://t.co/paiDEOoOlS

[Yael David @Yael_David__]

Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩
@Penn @PrincetonChem
https://t.co/2K2TszOc9C

[The Muir Lab @MuirLab]

Congratulations to Christian, Girum, Nick, Xuanjia, and Yutong!

Link: https://t.co/KoOKDGH6Pd

@PrincetonChem @PrincetonInnov

[The Muir Lab @MuirLab]

What if protein function could be triggered only when the right cell cues are present? With SMART, we combine split inteins and logic gating to create a programmable system for cell-specific protein ligation, thus opening new doors for synthetic biology and cell targeting.

[The Muir Lab @MuirLab]

We anticipate that this technology will enable targeted formation of biomolecules with reduced off-target toxicity. This paper is the start of many applications for SMART and stay tuned for more!