The Maze Lab

Understanding the complex interplay between chromatin regulatory mechanisms and neuronal plasticity. @icahnmountsinai @Sinaibrain @HHMINEWS

[The Maze Lab @themazelab]

I am absolutely humbled and honored to have been selected as a new HHMI Investigator. A huge shout-out to all of my brilliant lab members (past and present), outstanding collaborators and incredible mentors along the way who made this a possibility!!

[HHMI @hhmi_science]

HHMI News: We are proud to announce our 33 new #HHMIInvestigators. These individuals have the potential to make transformative discoveries over time and we look forward to seeing where their ideas lead them. https://t.co/HziK6G5Q6y

[Friedman Brain Institute @SinaiBrain]

How #Pregnancy & the #Postpartum period trigger lasting changes in the #MaternalBrain remains unclear. Here, @chanjeneration, @themazelab, et al. @IcahnMountSinai investigated the persistent effects of reproductive experience in the maternal brain @Nature
https://t.co/9fxzJCoSqu

[The Maze Lab @themazelab]

dopaminylation in humans and mice. A huge step forward for understanding the biology of parenthood, and the broader role of monoaminylation in the brain.
Enormous congratulations to Jen and thanks to all our incredible collaborators and reviewers. Hope you all enjoy!

[The Maze Lab @themazelab]

So excited to highlight our new work led by @chanjeneration, a postdoc in my lab recently awarded a K01 and BWF award (and on the job market!), out in @Nature!
This project identifies a novel role for dopamine in permanently remodeling the maternal brain through histone H3

[Jennifer O'Chan @chanjeneration]

Thrilled to share my main postdoctoral work out @Nature! This project tackles a fundamental question: how do pregnancy and postpartum experiences promote lifelong changes to the brain? https://t.co/BLnGSXzCHO

[Friedman Brain Institute @SinaiBrain]

April is #GraduateStudentAwareness Month and we are proud to highlight Rasika Iyer, a PhD student @themazelab !👏Beyond the lab, as Co-President of @SinaiNeuro & a leader at Mount Sinai’s GEMS, Rasika is a dedicated advocate for science outreach & education in #NYC! WOW!💯

[Leslie Vosshall PhD @leslievosshall]

Scientific publishing needs to change. In a new preprint, HHMI President Erin O'Shea and Bodo Stern argue that the incentives are misaligned. Researchers should be evaluated on what they choose to share, not what journals select. I’m proud that @hhmi_science is leading the way. Read the preprint here: https://t.co/CV1iiwgIvY

[Ted Abel @TedAbelneuro]

Novel perspectives on neurochemistry in a terrific ⁦@IowaMed⁩ ⁦@UIowaNeuro⁩ seminar today by Ian Maze! 🧠 ⁦@ian_maze2⁩ ⁦@IcahnMountSinai⁩

[The Maze Lab @themazelab]

an autonomous chromatin signaling axis whereby H3Q5ser is read by the Quinone reductase enzyme 2 (QR2) to support human neuronal gene expression and cellular maturation. Happy reading, everyone!

[The Maze Lab @themazelab]

Interested in histone H3 serotonylation? Then check out our brand new preprint out today! This work was spearheaded by Instructor extraordinaire, Dr. Min Chen of the Maze Lab, and represents another great collaboration with the labs of Drs. Haitao Li, @MuirLab, David Li, Samuele

[bioRxiv Molecular Biology @biorxiv_molbio]

Quinone reductase 2 reads H3 serotonylation to support neuronal maturation https://t.co/tjsQ5c5gjj #biorxiv_molbio

[The Maze Lab @themazelab]

Marro, and many others! Since H3 serotonylation occurs at Gln5, we (and others) have previously focused much of our attention on the mark's interactions with adjacent H3K4me3 in guiding permissive gene expression in the brain and beyond. Here, however, we have identified

[Ishmail Abdus-Saboor @IshmailSaboor]

2nd- or 3rd-year PhD student? Applications for @hhmi_science's #GilliamFellows Program open 9/1!
Robust dissertation support, an incredible community of scientists, tailored professional development
(for you *and* your thesis advisor), & so much more. https://t.co/S4v2Zoirh5

[Trends in Neurosciences @TrendsNeuro]

Check out the January 2026 issue of Trends in Neurosciences:
https://t.co/88OpdsM5sh

Free featured content & more:
https://t.co/i0FcV9dbnH

Cover article: ‘Reimagining biogenic amine signaling in the brain and beyond’, David Vinson & Ian Maze @themazelab
https://t.co/Uf0DiBSZSx

[Friedman Brain Institute @SinaiBrain]

CONGRATULATIONS to @IcahnMountSinai's Dr. Ian Maze on being endowed as a Mount Sinai Professor. This well-deserved recognition is the highest academic distinction a university can bestow upon a faculty member. Incredibly proud to have Dr. Maze as a colleague & mentor!👏

[The Maze Lab @themazelab]

Reimagining biogenic amine signaling in the brain and beyond: Trends in Neurosciences https://t.co/2qsfyJ6SoL

[Friedman Brain Institute @SinaiBrain]

🎉CONGRATULATIONS to the #MazeLab's @BenjaminWeekley who has received an @NIH F32 this year from @NIMHgov to study "Mechanisms of Histone Serotonylation and MLL5 in Coordinating the #Epigenome during #Neurodevelopment". Learn More about Dr. Weekley's work👉https://t.co/i8mQIw4jqx

[One Mind @OneMindOrg]

The One Mind Rising Star Awards were created to fuel bold ideas that improve lives, and 2017 Awardee Ian Maze, PhD, is a powerful example of that vision in action. Congratulations to Dr. @ian_maze2 on receiving the ACNP Daniel H. Efron Research Award for his groundbreaking work that's reshaping how we understand the brain & mental health.

When Dr. Maze received his Rising Star Award, One Mind invested in his pioneering effort to develop a simple blood test that could identify who is most vulnerable to stress, who may develop major depression, & who is most likely to benefit from certain antidepressant medications. This kind of test could transform mental health care by helping people get the right support & the right treatments faster.

That early support helped accelerate discoveries that have continued to push the field forward. Today, Dr. Maze is a Professor & Director of the Center for Neural Epigenome Engineering at @IcahnMountSinai & one of the youngest Howard Hughes Medical Institute Investigators.

His career reflects exactly why the Rising Star Awards matter: identifying exceptional scientists early & giving them the platform to make breakthroughs that improve lives.

Learn more about the Rising Star Awards: https://t.co/pVpL8APnvq

Read the ACNP's full press release: https://t.co/7QblDa6A8W

[The Maze Lab @themazelab]

So incredibly honored to be one of this year’s recipients of the @ACNPorg Daniel H. Efron Research Award, along with my friend and colleague @TheErinCalipari . Shout out to all my amazing current and former lab members (and our outstanding collaborators) who made this a reality!

[ACNP @ACNPorg]

Congratulations to Ian Maze, Ph.D. and Erin Calipari, Ph.D. for being awarded the Daniel H. Efron Research Award. 🎉#ACNP2026

[HHMI @hhmi_science]

Calling all rising juniors & seniors: Interested in biological or biomedical research? Apply now for our ’26 Summer Undergraduate Research Experience Program! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: https://t.co/dhQol9H28o

[Barriga Lab @Mech_Morph_Lab]

New preprint alert!!
In our last work we have found that Tissue stiffening primes migratory cell states by allowing histone serotonylation! #biomechanics #xenopus #chromatin #neuralcrest #devbio #cellmigration #frogpower

https://t.co/r5miQldHxh

[Yael David @Yael_David__]

Thrilled to announce the upcoming Center for Epigenetic Research Symposium @MSKCancerCenter on Nov 17! 🎉 A full day of cutting-edge science featuring stellar external speakers & our outstanding trainees. Registration is now open! Join us in NYC or virtually from anywhere! link⬇️

[Sasha L. Fulton @SashaLFulton]

So excited my doctorate work (and this excellent Preview by Yuhui Cui) is finally out @Neuron!

We used human MDD profiling + mouse manipulation studies to identify an epigenetic regulator linking OFC astrocyte reactivity -> neuronal hyperexcitability -> stress susceptibility.