🚨Preprint alert!
STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs
▪️ Done in 1 week with ~100% efficiency
▪️ Markerless and near-scarless approach performed in >10days in a single-well
▪️ Carrying not one but two (single-copy) payloads
See🧵below!
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly?
🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n)
Link: https://t.co/4BKAf4Or90
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Our STRAIGHT-IN Dual platform is officially out at @natBME 🔥🚀
A big step forward for programmable stem cell engineering — faster, cleaner, and more versatile.
Link📰: https://t.co/uQp7urNFKq
Don’t miss the 🧵 from the one and only @GallowayLabMIT breaking it all down 👇
New career goal unlocked:
✅ Attending the #SynBio24 conference with my twin brother @marcblanch94.
Thanks @GallowayLabMIT@billerbeck_s@ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️
https://t.co/E1u0dh3Sq1
What characteristics should an MPS have to be useful for modeling human phenotypes?
In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings.
https://t.co/t6F0L0w1Bq
Super thrilled to be part of the reNEW #ARTxSCIENCE competition! Choose your favorite image (obviously mine 😉) showing some exciting new work happening with another postdoc and myself! https://t.co/9AI0LHyjWy
#LUMC@MummeryLab#cardioid#confocal#stemcell#cardiac
Join Professor Christine Mummery (@MummeryLab), #reNEW Leiden @LUMC_Leiden, for a panel discussion at #ISSCR2024 on 'Use of Standards for Stem Cells in Non-Clinical Research' on Fri 12 July, 1.30pm-3.00pm CEST in Hall G2, Level 2.
Kicking off the last session of Day 1 #ISSCRCincy is @MummeryLab with a fantastic update on her work on hpsc-derived cardiovascular tissue to study disease. @ISSCR
We are pushing stem cell research further than ever before. Meet Professor Christine Mummery. Her work focuses on understanding cardiovascular development and disease mechanisms.
All reNEW researchers are leaders within their field, with a strong track record of scientific excellence. Together, they work to turn their research into real therapies that improve the health of people around the world.
See full video: https://t.co/qxbvmfDnm3
@GlobalLumc@MummeryLab@MCRI_for_kids@UCPH_Research #stemcellresearch #stemcelltherapies #cardiovasculardevelopment
Congratulations to postdoc Ben Johnson, from the Richard Davis and @MummeryLab at reNEW Leiden for receiving a prestigious Marie Curie fellowship. Ben will use the fellowship to develop a stem cell based model for myocardial infarctions. Read more:
https://t.co/bgQf3np9H6
Delighted to welcome Albert Blanch Asensio @A_BlanchAsensio as a visiting student with our lab! Albert pioneered STRAIGHT-IN with Richard Davis and @MummeryLab. We're excited to build circuits in these landing pad iPSC lines!
https://t.co/xbAd7hABnM
🧐 #MeetTheSpeaker!
🔬 @MummeryLab@LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine.
https://t.co/fyPhnJm4Un
Thrilled to be awarded the NWO-XS grant to generate an inducible heart attack stem cell model in a fantastic lab! @MummeryLab @reNEW_Global https://t.co/WWG6SdBktU