Clyde Yancy, MD, MSc

Chief, #Cardiology at @NorthwesternMed @NMCardioVasc. Magerstadt Professor of Medicine, Vice-Dean, Health Equity @NUFeinbergMed. Past President @American_Heart

[Gregg Fonarow MD @gcfmd]

@GamerPhilDoc @JACCJournals @TIMIStudyGroup @SJGreene_md @JavedButler1 @MKIttlesonMD @AndrewJSauer @hvanspall @ankeetbhatt @FudimMarat @mvaduganathan @vbluml @DLBHATTMD Complementary to EMPULSE findings

✅ Hard event ⬇️ by meta-analysis of RCTs

All-cause ☠️ at 60 days median f/u ⬇️ by 39%

RR 0.61, 95% CI 0.47-0.81, p=0.0005

ARR 24 per 1000 fewer ☠️s (95% CI 33 to 12)

NNT 42 (95% CI 30-84)

https://t.co/FaKkMGii8P

[Gregg Fonarow MD @gcfmd]

📉⚡ Early + complete GDMT = best outcomes

The four pillars work fast 🚀 and work best together 🛡️

Simultaneous/rapid sequencing to all four components of quadruple GDMT at 🎯 doses (as well tolerated) should be the standard of care for all

❤️‍🩹 #GDMT #HeartFailure https://t.co/LvqP2YmHWe

[Gregg Fonarow MD @gcfmd]

⏱️❤️ Time to GDMT is a KEY HF quality metric!

🔵 HFrEF → 4 pillars: ARNI + β-blocker + MRA + SGLT2i 💊

🟣 EF >40% → 3 pillars: SGLT2i + nsMRA + GLP-1 🎯

Start Day 1, titrate fast, don't wait ⚡🏆

📄 JCF 2023 #HeartFailure #CardioTwitter

[NM Cardiovascular @NMCardioVasc]

“We really want to ensure that our patients are getting met where they live and getting the care that they deserve in their own neighborhoods,” says Palak Shah, MD.

On Better Edge, Dr. Shah shares his vision to expand access to advanced heart failure care across the Chicago area. Listen here: https://t.co/iBttlvh7im

[NM Cardiovascular @NMCardioVasc]

Heart failure with preserved ejection fraction has nuanced pathways for diagnosis, management and long-term care. In a recent Medical Stories feature, Clyde W. Yancy, MD, MSc (@NMHheartdoc), and Jane E. Wilcox, MD, MSc (@WilcoxHeart), provide clinical perspective on sex-specific prevalence, disease progression and the importance of individualized management strategies.

Watch here: https://t.co/p0PHRE0uaL

[NM Cardiovascular @NMCardioVasc]

In @theNAMedicine, Northwestern Medicine cardiologists Clyde W. Yancy, MD, MSc (@NMHheartdoc), and Nilay S. Shah, MD, MPH (@NilayShahMDMPH), share that earlier assessment, personalized low-density lipoprotein targets, and broader risk evaluation support a more complete approach to preventing cardiovascular disease in patients: https://t.co/WczTuqo8Mw

[C. Michael Gibson MD @CMichaelGibson]

Reminder! Join us on Monday, July 20, 2026, from 9:30-10:30 am ET for Baim Grand Rounds with @scottdsolomon, presenting “Heart Failure with Mildly Reduced or Preserved Ejection Fraction – the Long and Winding Road.” Zoom link: https://t.co/qnyjWFye6B

[Gregg Fonarow MD @gcfmd]

💊❤️ HFrEF polypill, 2 new RCTs:

��� POLY-HF: +3.3 pts LVEF, 60% ↓ HF hosp/ED, 79% vs 54% adherent

🧪 COMBO-HF-X: +8.7% adherence, 10➡️7 pills/day, 93% would keep it

🛡️ No safety penalty

Fewer pills, more pillars 🙌

Nat Med & JACC:HF 2026

#HeartFailure #GDMT

[JACC Journals @JACCJournals]

ACC, AHA, ESC & World Heart Federation call for a new era of equity-centered CV care. A new #JACC editorial outlines 7 priorities to advance #HealthEquity science and ensure all patients benefit from modern cardiovascular medicine. https://t.co/ttw5At2TVZ #CVD #cvPrev

[Gregg Fonarow MD @gcfmd]

Myth: most patients newly presenting with HFrEF can't tolerate simultaneous, polypill, or rapid-sequence quadruple GDMT because of dangerous hypotension risk

[NM Cardiovascular @NMCardioVasc]

At the Women’s Heart Care Panel, our cardiologists Jane E. Wilcox, MD, MSc (@WilcoxHeart), Priya M. Freaney, MD (@PriyaFreaneyMD), Sarah A. Goldstein, MD (@sgolds13), Ranya N. Sweis, MD, MS (@DrRanyaSweis), Linda Lee, MD (@Linda_Lee_MD), and Clyde W. Yancy, MD, MSc (@NMHheartDoc), shared their clinical insight on cardiovascular risk across a woman’s lifespan, including menopause, treatment considerations and prevention.

Our physicians connect with our community to support informed, proactive approaches to women’s cardiovascular health.

[C. Michael Gibson MD @CMichaelGibson]

The recording from yesterday’s Grand Rounds with @NMHheartdoc titled “Health Equity: Current Status and Future Approaches” is now available on the Baim website. You can find it here: https://t.co/CxzhatTyJG

[nancyatheart @NancyatHeart]

Last night we celebrated the incredible leaders and organizations making an extraordinary impact on the @American_Heart mission during our annual National Volunteer Awards event. This year’s honorees exemplify what it means to take bold action, meet people where they are, and remain relentless in the pursuit of longer, healthier lives for all. Please join me in applauding this extraordinary group of honorees whose service and vision are nothing short of lifesaving.

Read their inspiring stories: https://t.co/kFQO95IB1m

#NVA2026

[Gregg Fonarow MD @gcfmd]

💔 Patient with HF 🏨 for worsening

✅ SGLT2i Rx with in-🏨 initiation, 1st 60 days

☠️ ⬇️ by 39%

RR 0.61, 95% CI 0.47-0.81, p=0.0005

ARR 2.4% fewer ☠️s (95% CI 3.3%-1.2%)

Safe, no net ⬆️ AEs

💊 Cost $10 (dapagliflozin 10 mg)

https://t.co/FaKkMGii8P

[Gregg Fonarow MD @gcfmd]

💊 ARNI for HFrEF

❤️‍🩹 Benefits>>>potential risks

⏱️ Rapid ⬇️ events

🥇First line over ACEI or ARB

⚖️ High value

🔰No significant heterogeneity of treatment effects

🎯 The most precision guided and personalized approach to use:

✅ Treat all eligible individuals w/o CIs

[NM Cardiovascular @NMCardioVasc]

In Northwestern Medicine Heart Conversations episode 7, Clyde W. Yancy, MD, MSc, (@NMHheartdoc), and Jane E. Wilcox, MD, MSc, (@WilcoxHeart), are joined by Priya M. Freaney, MD, @PriyaFreaneyMD), and Sarah A. Goldstein, MD, (@sgolds13), to discuss cardiovascular risk during pregnancy and menopause, as well as sex specific statin management.

Listen to the full conversation here:
https://t.co/LhXu92CMNq

[Clyde Yancy, MD, MSc @NMHheartdoc]

👏🏾👏🏾👏🏾 @JTWilkinsMD @NMCardioVasc

[Clyde Yancy, MD, MSc @NMHheartdoc]

So grateful to my friend & colleague @ArdehaliHossein - what a fabulous visit #Tucson. Thanks once again to the DOM #UnivAZ

[Clyde Yancy, MD, MSc @NMHheartdoc]

👏🏾👏🏾👏🏾 @JTWilkinsMD @NMCardioVasc

[NU Internal Medicine @NU_IntMed]

Shout out to @JTWilkinsMD who joined the @TODAYshow to discuss how individuals should adjust habits to better take care of their cholesterol health.

Read Here: https://t.co/hrWnJw3S1T

[Clyde Yancy, MD, MSc @NMHheartdoc]

So grateful to my friend & colleague @ArdehaliHossein - what a fabulous visit #Tucson. Thanks once again to the DOM #UnivAZ

[Hossein Ardehali @ArdehaliHossein]

It was great to host my friend and someone who I admire, @NMHheartdoc in our house with my good friends @heshamasadek, @sadayappanlab, @J_Wertheim1. Wonderful evening! @UAZ_MDPHD @UAZHeart @UAZMedicineEdu @UAZMedTucson