Deborah Naon

[Federica Vinelli @FedericaVinelli]

Very interesting: mTORC2-NDRG2-CDC42 axis drives mitochondrial fission indipendently of DRP1

[Deborah Naon @NaonDeborah]

@AboutPatna @orozco_lab @IRBBarcelona @AntonioZorzano Thank Tomás!

[Deborah Naon @NaonDeborah]

@albert_qr78 @LabScorrano Thank you Albert for your help!!

[Deborah Naon @NaonDeborah]

@TheVilchezLab @LabScorrano @carlescanto @AntonioZorzano @SatokoS_PhD Thank you, David.!!!

[Deborah Naon @NaonDeborah]

@carlescanto @TheVilchezLab @LabScorrano @AntonioZorzano @SatokoS_PhD Remember the origin of variants !! Nice times at IRB!!!!

[Deborah Naon @NaonDeborah]

@carlescanto @TheVilchezLab @LabScorrano @AntonioZorzano @SatokoS_PhD Thank you Carles. We are so happy!!!

[Deborah Naon @NaonDeborah]

@jourdainlab Thank you !Alexis

[Alexis A. Jourdain @jourdainlab]

Splicing x mitochondria 💯 loving it

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science https://t.co/XcPV3HIQrb

[Deborah Naon @NaonDeborah]

@iannisaifantis1 @LabScorrano Thank you Iannis!!

[Deborah Naon @NaonDeborah]

@glytsou @LabScorrano Thank you Christina!!!

[Deborah Naon @NaonDeborah]

@orozco_lab @IRBBarcelona @AntonioZorzano Thank you Orosco Lab for your great work.!!!

[Orozco Lab @orozco_lab]

The results of the beautiful collaboration with the lab of @AntonioZorzano are out in Science! In the paper, we modeled how previously uncharacterized isoforms of MFN2 provide mechanical tethering between mitochondria and ER. Video made with #molywood 🙂
https://t.co/yyyF6gNZxC

[The ScorranoLab @LabScorrano]

Ermin2 and Ermit2 do not influence mitochondrial morphology. Ermin2 regulates ER shape and luminal connectivity. Ermit2 is enriched in MAMs. Ermit2 increases ER-mito proximity measured by ddGFP, FEMP, EM. In cells, Ermit2 supports Ca2+ transfer from ER to mitochondria 3/

[The ScorranoLab @LabScorrano]

Mfn2 tethers ER to mitochondria, but what's its partner on the ER? How does it tether heterotypic organelles without fusing them? Deborah discovered that Mfn2 is alternatively spliced in two variants Ermin2 and Ermit2 that lack the GTPase domain and go only to the ER. 2/

[The ScorranoLab @LabScorrano]

In the liver, Ermit2 facilitates ER-mitochondria phospholipid transfer, reduces ER stress caused by Mfn2 ablation and in models of NASH. Molecularly, Ermit2 CC2 domain is required to interact with CC1 and CC2 of mitochondrial Mfn1&2, in a complex apt to stabilize ER-mito 4/

[The ScorranoLab @LabScorrano]

@NaonDeborah's paper, 8y of collaboration with @AntonioZorzano's lab is out! Kudos to Deborah, @SatokoS_PhD and all authors! Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science https://t.co/Rwe8LHJtLR #MCS #mitochondria #ER 1/

[The ScorranoLab @LabScorrano]

This was a very long journey... Thanks @NaonDeborah for your ingenuity and perseverance. She is a star, look out for her next discoveries. Thanks @ERC_Research @FondationLeducq @MDAUSA @mur_gov_ for support, @VIMMPadua @DiBio_UniPD @IRBBarcelona for making this possible. 6/6 LS

[Deborah Naon @NaonDeborah]

@LabScorrano @ERC_Research @FondationLeducq @MDAUSA @mur_gov_ @VIMMPadua @DiBio_UniPD @IRBBarcelona I thank you, Luca, for your full support and perseverance throughout good and bad times! I'll never forget it!.

[Deborah Naon @NaonDeborah]

@LabScorrano @LukashAllan @AnnaPellattiero Congratulations!!! Fantastic work!