An exciting new oral antiviral for SARS-CoV-2!
A NEW study presents the systematic design of quinoline-containing SARS-CoV-2 papain-like protease (#PLpro) inhibitors as potential oral antiviral drug candidates to treat Covid-19 patients 1/
Published. Persistence of Virus must be addressed. 16M affected! So many questions. What is the cause—the infection or the vaccine or both? Is Spike the culprit? How do we treat it? Consequences of persistence? Will this be the next HPV? Could it have been prevented? #LongCovid
I am excited to be part of this paper: "Targeting the SARS-CoV-2 reservoir in long COVID" by @microbeminded2@MichaelPelusoMD and team, describing clinical trial recommendations for long COVID
@polybioRF
https://t.co/sGwDfFGI0U
Great piece from @mileswgriffis & @thesicktimes
“Despite.. the many challenges of studying.. #LongCovid, scientists may be closing in on biomarkers..
Immunologist Van Weyenbergh identified.. a potential blood-based biomarker for LC with 94% sensitivity”https://t.co/j7qVFQBrFX
Muscle weakness is one symptom of post-exertional malaise (PEM).
This is experienced by those with:
1. Long COVID
2. ME/CFS
3. TBI
4. MS
Data suggests this is to blame...🧵
\ The Discovery:
Scientists at Washington University in St Louis discovered that neuroinflammation causes neurons to make IL-6.
The IL-6 communicates with skeletal muscles to cause profound muscle fatigue.
Here is how...
Read the full study 👇
https://t.co/hBVPdLc9Ir
\ Therapeutic Potential:
The FDA approved 4 IL-6 monoclonal antibodies:
- Satralizumab
- Tocilizumab
- Siltuximab
- Sarilumab
Could they restore mitochondrial function in Long COVID and ME/CFS patients?
Last week, I led a hearing in the HELP Committee on long COVID. We must listen to the millions of Americans struggling with long COVID and give this issue the urgent attention it demands. If you missed it, tune in below. https://t.co/8tBXn02uib
Below is a better link that has links to submit:
Ideas for therapeutics & biologics for RECOVER-TLC
Interest in serving on RECOVER-TLC working groups
Biomarkers for Long COVID
General feedback
Responses submitted up until February 1
#LongCOVID#pwLC
https://t.co/lW2rUgcHLs