Will Bailis @metaBailism trying to figure out the inner works of our beloved mentor Richard Flavell @FlavellLab using two exceptionally handsome scientists
@elonmusk Academia is also the place where we unlock the secrets of life and the universe, harness our immune system to fight disease, and advance all aspects of life. It really all comes down to personal motivation and integrity. "The scientist is the true warrior" - Aaron Ciechanover
A terrific synopsis of bistability in innate immune signaling by Jayajit Das and Giuseppe Giuliani, previewing our paper on macrophage tolerogenic memory published today @Immunity https://t.co/qIGIV0IIC3
@WiringTheBrain Very useful framework to think about proteins. Perhaps we can put another layer onto it - structural flexibility. Enzymes and receptors should fall on the right side of this axis, while unstructured proteins should fall on the left, and potentially display more properties
Our new work published today @NatrureMedicine https://t.co/GaQVx8wUQP
The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann).
Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms@NowarskiLab
Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.
New research from @NowarskiLab uncovers a 'switch' in the gut that can provide protection against harmful intestinal inflammation. The work was published in @ImmunityCP https://t.co/3rKo9LrEkE
Very excited to share our paper showing that IL-18 activation of the salt transporter NCC programs durable immune tolerance in the gut! We found that NCC induces a metabolic switch in macrophages that stabilizes fatty acid oxidation and prevents glycolytic reprogramming ⬇️