Excited to share the first part of my PhD work, revealing a major role for HIRA-mediated histone H3.3 deposition in maintaining 3D organization of active chromatin across scales, supervised by @GAlmouzni in collaboration with @mamartirenom@leonidmirny https://t.co/2WD4gv8W8c
Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP: https://t.co/w3jM0i53Yf
Check this new paper by our lab, Raphaël Guérois' and @CejkaLab where Alphafold, biochemistry and yeast genetics uncover how pSae2/pCtIP activates Mre11 nuclease!
The team has a postdoctoral position open in Molecular & Cellular Genetics, to study replication fork repair pathways in the nuclear space (M/F) | EURAXESS https://t.co/Sr9QyKCuGg . application to be sent at [email protected]. Please RT;
Applications for AlgoSB 2024 "Structural bioinformatics in the AlphaFold / Deep Learning era" are open until July 14!
More details on the website: https://t.co/jCglGU3Mta
French 3R meeting 2024. Congratulations to Victoria Rojat from @IBENS_ENS, Amelie Besombes from Institut Jacques Monod @IJMonod, and Jerome Savocco from @ENSdeLyon for winning the poster price from la Société Francaise de Génétique. SFGénétique @SFGenetique.
New preprint 🚨
We investigated how protein-RNA interface structure evolves by thoroughly analyzing the conservation of contacts among 2022 pairs of homologous interfaces.
Work with Ikram Mahmoudi, Chloé Quignot, Carla Martins
@I2BCParisSaclay@CEA_Joliot
Here we are! Looking forward to open it to community in tandem with Krios at Soleil synchrotron arriving soon. Congrats at Stephane Bresssanelli and the I2bc cryoEM platform
@jessica_compbio, @diegojavierzea and colleagues at @CEA_Joliot and @I2BCParisSaclay show that AlphaFold2 accurately predicts protein interfaces involving disordered regions by combining different delimitations and sequence alignments.
https://t.co/9fOY42zIVI
Using reconstitued complexes, we found that the long KER helix mediates DNA binding and stimulates pombe CAF-1 association with PCNA. Also, the WHD domain behaves differently from other species. Great collaboration with @OFrancoiz and @GAlmouzni.
https://t.co/KYsLXJKmRO @eLife
Deadline approaching for the EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance", June 17-20, 2024, Leiden, the Netherlands. Speaker slots available!
Register before April 1, 2024!
https://t.co/xBY98lDOOX….
Our research on using AlphaFold2 to predict how peptides from disordered regions bind proteins has now been published with @SpringerNature in @NatureComms
I am very happy to share the updated paper with you 😀
https://t.co/Pw9ny7gH3E