Omar Hamed

Postdoctoral Fellow, University of Toronto. GPCRs, molecular pharmacology, cell signaling. Clinical Pharmacist (Ontario College of Pharmacists)

[Omar Hamed @OmarHamedca]

Our new study in @NatureCVR

Team effort w/ @UofT @UHN @trogersresearch & co-authors! @CristineReitz, Uros Kuzmanov, Phyllis Billia & @A_Gramolini https://t.co/Bdq6FbP6FH
https://t.co/0Qw590GB6F

[drugdiscoverypapers @drugdiscpapers]

The "β-Blocker" Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with K A Values Distinct from their Equilibrium Dissociation Constants as β2-Adrenoceptor Antagonists: Evidence for Functional Affinity https://t.co/9LALp1nQ8E

[BryanRoth @zenbrainest]

SHOTS RETURNED!
'The reason why carvedilol shows a superior profile in clinical practice remains entirely speculative and needs to take into account all properties of this β-blocker, including ... α-adrenergic receptors.'
https://t.co/5xTIBf7gnw

[Fiona Marshall @FionaHMarshall]

Wow - xanomeline can be an orthosteric and allosteric agonist at the same time. Amazing how many times structures of GPCRs tell us something new about the pharmacology of ligands. Congratulations to the team at Monash for this fascinating work. https://t.co/q4yULGUqWa

[Aashish Manglik @AashishManglik]

Check out this amazing paper from my @UCSF colleague Roshanak Irranejad demonstrating the importance of cAMP location in cardiac function. Impressive study spanning cell biology to physiology in two model organisms! https://t.co/WQcwfYutYE

[Omar Hamed @OmarHamedca]

@Labouta_Lab @UofT @UnityHealthTO @UofTPharmacy Congratulations! Welcome to Toronto. All the best.

[Peter Dirks @BrainSurgn1989]

Very pleased to share our latest paper led by PhD student Akram Hamed and great collab with Ben Simons (U Cambridge) and Lincoln Stein(OICR)! Single cell neural stem cell maps and brain tumor insights!

https://t.co/kdrSStFgfd

[Omar Hamed @OmarHamedca]

Check out our work just published @BrJPharmacol. We studied the mechanism of formoterol-induced inflammatory genomic response in airway epithelia. A step towards understanding the adverse effects of β2-adrenoceptor agonist monotherapy in asthma.
https://t.co/ycSpSU7cMg

[β-arrestin Bot @ArrestinBot]

beta(2)-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of beta-Arrestin 2

https://t.co/8horHHUyKz

#GPCR #signaling #pharmacology