Coke on the rocks (he/him)

Physicist and Neuroscientist. Spielkind. Cheap cocktails and dancing queens to the front of the line. On the pursuit of happiness (:

[Coke on the rocks (he/him) @OneAlchemist]

#featGarcíaLorca en mi avatar debe ser lo más #pride de la vida entera

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

One of the most consequential aging papers this year: an open Nature study integrates >11,000 transcriptomes across 25+ tissues and four mammals, building interpretable clocks for chronological age and expected mortality. https://t.co/V1QVoYFjxg

[Silvi Rouskin @silvirouskin]

Ribosomal DNA producing MICRO RNA ??🤯🤯🤯🤯🤯🤯🤯🤯🤯 Biology never ceases to surprise me !

[Loïc A. Royer 💻🔬⚗️ @loicaroyer]

1/📢 New preprint! Do you actually need a biology-specific foundation model to predict how cells respond to perturbations? Surprising answer: a general-purpose tabular model - never trained on a single cell - matches or beats the specialists!

📄 https://t.co/nRvpH27djc

@biohub

[Shiv Grewal @grewalsh]

Introns have a hidden regulatory role! 🧬🎉
Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression
https://t.co/tVTWTewauk

[Science Advances @ScienceAdvances]

The protein GDF15—already shown to be a late-life indicator of dementia risk—may also be a midlife biomarker, new research finds. https://t.co/6xn2wOnQGO

[Xin Jin, PhD @xinjin]

Very exciting!

[Nature Reviews Physics @NatRevPhys]

Data-driven discovery of dynamical models in biology https://t.co/dNoqP4hAJq

[Coke on the rocks (he/him) @OneAlchemist]

@LocasaleLab for the record, she has several ongoing projects in collaboration with some of the top AI scholars at UC Berkeley. Try checking her latest research (:

[Ihtesham Ali @ihteshamali]

Jennifer Doudna won the Nobel Prize for gene editing and went on Bloomberg to say the chatbots everyone is betting on cannot innovate at all. Every promise Silicon Valley is making about AI curing disease just hit the one person qualified to check it.

She has spent her whole career inside the actual frontier of curing disease.

So when she talks about what AI can and cannot do in biology, she is not guessing. She is reporting from inside the lab.

Her words were blunt. She is not seeing chatbots innovate. They summarize data. They write reports. They do not come up with a brand new idea nobody has ever had.

Then the interviewer pushed. So you're saying AI can't innovate?

Doudna did not flinch. She does not know if it can't. She just does not see it doing it right now.

This lands harder when you remember who is making the opposite case. Sam Altman says AI will eliminate disease within five years. Larry Ellison says AI will cure cancer in a 48 hour window.

An OpenAI executive even floated that the company should get a cut of sales on any drug discovered through ChatGPT. Doudna answered that in two words. Good luck.

Even the cancer specialists Altman is selling to keep warning that cancer is not one disease but hundreds, each needing its own cure, and that compute does not skip the years of lab work.

Her reason is simpler. Biology is hard. You cannot simulate your way to an understanding of the human body.

The people promising cures are the ones selling the tool.

The person who actually won a Nobel building them is telling you it has not happened yet.

Source: Bloomberg Originals

Watch the full video on their official channel.

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Universal transcriptomic hallmarks of mammalian ageing and mortality

https://t.co/D32VclIHNt

[Daisy Ding @daisyding_]

To solve aging, we first need to measure it. Excited to share our study in @NatureMedicine! Different cell types age at different rates within our body. From a tube of blood, we track aging across 40+ cell types, from immune cells to neurons, revealing signatures that forecast disease risk and resilience. @wysscoray 🧵1/9

[Gerardo L. Munck @GerardoMunck]

UNDP Report at LASA

For the upcoming @LASAweb conference, I organized a panel to discuss the new @UNDP report on democracy and development.

The panel includes @MichMuschett, Adam Przeworski and @mriost

You can download the report here: https://t.co/6mjyfNXKhX

[Santa TechLaw @SantaT3chL4w]

Una orquídea para Ruth @Ruth_Lopez1977
#LibertadParaRuthLópez🌸 #LiberenARuth🌸 #TenganDecencia

[𝗠ó𝗻𝗶𝗰𝗮 ®𝗼𝗱𝗿𝗶𝗴𝘂𝗲𝘇 @MonikR84]

Ruth López, reconocida como una de las mujeres más influyentes, ha sido la voz de muchas de nosotras.
Hoy acompañamos su lucha y alzamos la voz por ella, por su libertad.
#LibertadParaRuthLópez
#JuicioPúblicoParaRuth

[teleSUR TV @teleSURtv]

🚨 ONU exige juicio justo para defensora de DDHH en El Salvador

🔴 La relatora de la ONU, Gina Romero, pidió un juicio justo para la abogada anticorrupción Ruth López, detenida desde 2025. Romero denuncia un patrón de criminalización a quienes luchan contra la corrupción. Su caso, con graves irregularidades, genera alarma internacional.

¿Qué papel deben jugar los organismos internacionales?

#ElSalvador #DerechosHumanos #teleSUR

https://t.co/beCIn9XShG

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

InflammAging and Human Diversity: Expanding Horizons in Age-Related Chronic Disease

https://t.co/HlUyxLSCqp

[Yafei Mao 毛亚飞 @yafmao92]

Thrilled to share our @NatureComms paper on a long-read human pangenome approach to nuclear‑embedded mitochondrial DNA (NUMTs) (https://t.co/LUrWkfXqj4). We build a high‑resolution NUMT map across diverse human genomes, reveal their population and epigenetic dynamics, and

[Héctor Lindo @hector_l_f]

Nunca imaginé que la prisión de Ruth López llegara al año.
Ante la incapacidad de justificar su encarcelamiento, era razonable esperar que el régimen buscara una salida que mitigara el costo político.

Sin embargo, la prolongada arbitrariedad —y la indecencia institucional— del caso ha expuesto ante la comunidad internacional algunos rasgos estructurales del Bukelato, por ejemplo:

🟡 La intolerancia frente a una voz incómoda, heroica, que defiende derechos humanos y documenta corrupción.
🟡 La instrumentalización del poder judicial y la erosión deliberada del debido proceso, incluso en casos sin vínculo alguno con pandillas.
🟡 La represión de la libertad de expresión como mecanismo de control político.
🟡 El revanchismo de un liderazgo que se proclama popular, pero que recurre a castigos ejemplarizantes para inducir la autocensura y disciplinar al resto de la sociedad.

Este caso no solo revela una injusticia individual; ilumina la arquitectura autoritaria del régimen.

#LibertadParaRuth
#JuicioPúblicoParaRuth

[Michael Paarlberg @MPaarlberg]

Ruth Lopez, a lawyer in El Salvador and anti-corruption investigator with a human rights NGO who was named one of BBC’s 100 most inspiring women, has been imprisoned by the Bukele government for a year, under a suspension of civil liberties supposedly targeting gangs

[Margarita Parada-Kusz @MParada_Kusz]

Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species | Science Immunology https://t.co/T0S61UOja4