Osvaldo Chara

Biophysicist/Modeller playing with tissues in Development and Regeneration
School of Biosciences, University of Nottingham
Also in @osvaldo-chara.bsky.social

[Osvaldo Chara @Osvaldo_Chara]

Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @iScience_CP!
https://t.co/Vd41YRyFMV

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[Osvaldo Chara @Osvaldo_Chara]

@stevenstrogatz I read about this in your amazing book Synk. Lovely to see how they actually look like! These letters truly represent a "singular" moment in mathematical biology!!

[Osvaldo Chara @Osvaldo_Chara]

Thanks to all co-authors, labs, and collaborators! ForSys is free & open source. Find the detailed usage description in the Protocol (https://t.co/f6CtJShR2b) and the code, example notebooks & full docs here: https://t.co/MZYX7bogcR Happy inferring! 🫧🔬

[Osvaldo Chara @Osvaldo_Chara]

🧵 New protocol out in @STARProtocols! We present a step-by-step guide for inferring mechanical stresses in tissues using ForSys, by @BorgesAugust, @hey_jero, @CeccarelliAS, @gbventur, @ksedzinski, @LopezSchier365 & @Osvaldo_Chara
https://t.co/f6CtJShR2b

[Osvaldo Chara @Osvaldo_Chara]

Scripting is also easy! Load your images into Frame objects, then pass them to ForSys: import forsys as fs → build frames{} per timepoint → forsys = fs.ForSys(frames) and then infer. Works for both experimental 🔬 and in silico 💻 data!

[Physics In History @PhysInHistory]

General Relativity for babies ✍️

[Can Aztekin @CanAztekin]

🔬 Diverse species. Stem cells. Highly international team. 🐸🐭
We’re looking for a Technical Assistant to join our stem cell–based research.
Interested?
Apply here 👉 https://t.co/wdTYrV7J6T

[Osvaldo Chara @Osvaldo_Chara]

@pandeybipink @kulich_ivan @ScienceMagazine @lokeshverma203 @UniofNottingham Congratulations Bipin, Malcolm and other colleagues! Brilliant work!!!

[Osvaldo Chara @Osvaldo_Chara]

@stevenstrogatz @ManilSuri Thanks for sharing, @stevenstrogatz ! Everything in this post is so refreshing! A lot of people attending to an event about philosophy of mathematics!! and in a public library!!

[Osvaldo Chara @Osvaldo_Chara]

Would you like to run our Cellular Potts Model (#CPM) of neuromast regeneration in #zebrafish? It is now available in the amazing #Morpheus repository:
https://t.co/HM71gI9uEO
Curious about the Science? Check our paper: https://t.co/l6O1uoPzxm

[Osvaldo Chara @Osvaldo_Chara]

A nice mix of maths 📐, computing 💻 & experiments 🔬! This adventure took place at @Cambridge_Uni , @UoNBiosciences and @UADEoficial !

[Osvaldo Chara @Osvaldo_Chara]

Thrilled to share this adventure on how zebrafish elongates its notochord! 🐟 Kudos to Carlos Camacho de la Macorra and @BenSteventon2 for leading it. @CeccarelliAS and I had so much fun modelling & uncovering unexpected predictions...

https://t.co/kpc2VY53sB

[Mark Chaplain @mcapellanus]

8.II

Our Mathematician of the Day is Daniel Bernoulli a Dutch-born member of the Swiss mathematical family. His most important work considered the basic properties of fluid flow, pressure, density and velocity, and gave the Bernoulli principle.

https://t.co/70jpN8pQEv

[Osvaldo Chara @Osvaldo_Chara]

The article shows that regeneration of a key part of the sensory nervous system in zebrafish can be achieved by a mechanism compatible with local control. Please get in touch if you have any questions!
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[Osvaldo Chara @Osvaldo_Chara]

Our results show that the tissue-wide regenerative response of the neuromast is consistent with a delayed proliferation switch modulated by the the number of neighbors.
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[Osvaldo Chara @Osvaldo_Chara]

Comparison of the model simulations with experiments on regenerating neuromasts previously subjected to laser ablation suggests that our hypothetical proliferation switches are a robust mechanism of regeneration control.
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[Osvaldo Chara @Osvaldo_Chara]

We parameterized the CPM using our recent estimates of cell-cell interactions within the neuromast using our new method of Mechanical Stress Inference ForSys!
https://t.co/VIDoStgMm4
Interestingly, these interactions allow the integrity of the organ to be maintained.
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[Osvaldo Chara @Osvaldo_Chara]

Curious about how to achieve organ-wide #regeneration through locally controlled cell proliferation? Check out our latest computational adventure addressing this problem in the #neuromast within the #zebrafish lateral line.
https://t.co/l6O1uoPzxm
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