Kaz Mizuno

Ph.D. Scientist,
Extracellular Matrix

[ASMB @amsocmatbio]

🧬Next up in our #ASMB2025 Matrix Masters series is Dr Billy Hudson (@VUMCDiscoveries ), a pioneer in basement membrane and kidney disease research whose discoveries transformed the field.

🎥Get to know him: https://t.co/E73GmfbhjU

[ASMB @amsocmatbio]

☀️ Summer is almost here, and summer school is in session!
Dive into the molecules that shape the extracellular matrix with lectures by Prof. Hans Peter Bächinger and Prof. Peter Yurchenco:
🧬Collagens: https://t.co/zfNZS2nWUw
🧬 Laminins: https://t.co/qru83mkrFA

[Matthew Herper @matthewherper]

People who don't follow cancer research often ask me why we haven't cured cancer. That perception masks a wonderful reality: We make amazing, stepwise progress every year, and the result is that many people live much longer today than they would have previously.

Right now we're in the thick of the annual meeting of the American Society of Clinical Oncology, the biggest research meeting on new cancer medicines, and this morning a bunch of really important studies dropped. I'm going to review them here.

This first image is the result for daraxonrasib, a treatment for pancreatic cancer that is generating consdirable excitement. The green line is the probability of living for patients who got the new drug; the gray one is the chemo control group.

If you follow cancer drugs, a chart like this will make your breath hitch a little. I'm going to review these and some other data here.

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[eLife - the journal @eLife]

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.
https://t.co/3y3dRwCRSL

[Nature Biotechnology @NatureBiotech]

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels https://t.co/FY3wVCeiUO

[Hans Clevers @HansClevers]

Polyisocyanide (PIC) hydrogel with the essential properties of #Matrigel. Functionalised with the integrin activating Yersinia protein #Invasin for #organoid growth. Joost Wijnakker et al. Great collaboration with Paul Kouwer's lab. PMID: 41091766
https://t.co/Ts9R30EQ5T

[Jennifer Young @nano_jenn]

📢 Call for paper submissions in @nature_npj npj Biological Physics & Mechanics special collection on:

Mechanobiology of the Extracellular Matrix!

📅 Deadline: 14 May 2026
🔗 https://t.co/uHYAuCZdyH

More info👇(1/7)

#ExtracellularMatrix #ECM #Mechanobiology #natureportfolio

[Hans Clevers @HansClevers]

1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. https://t.co/Y2EI9bhhWT

[LPE Blog @LPEblog]

Today, Fumika Mizuno explains how two powerful corporations came to control over 70% of the outpatient dialysis market — a case study in how public funding can entrench private power in health care.

https://t.co/phDQ4Zx7M0

[つぎは目指せ結婚40周年 @Thewifelover1]

Please find out the new collagen probes we used in our recent paper! https://t.co/LRd4ox6M1F
collagen probes are so useful. You can actually perform a "pulse-chase" exp. Those are a material breakthrough in collagenvresearch field.

[Kaz Mizuno @PDX_HND]

@tranejoan @The_MRC @ExDrosoScientia @rachelcowen @UK_NPAW @MCF_UoM Congratulations!!

[Journal of Cell Biology @JCellBiol]

Lift-out cryo-FIBSEM and cryo-ET reveal the ultrastructural landscape of extracellular matrix. A new study from Bettina Zens (@BettinaZens), Florian Schur @SchurLab and colleagues @ISTAustria: https://t.co/8IyWIRqbPi

#StructuralBiology #ECM

[The Fuchs lab @ElaineFuchsLab]

In case you missed it: our latest paper published last week in @ScienceMagazine unveils how vitamin A regulates the biology of hair follicle stem cells. Find the free access link here 👇🏼
https://t.co/ug7HwjEOtW
And a summary of our discoveries below:
https://t.co/WSkTeoKQHe

[Taina Pihlajaniemi @TainaPihlajanie]

It is sad to hear that Darwin Prockop has passed away. He was one of the giants in collagen research, and he made a second remarkable career in the stem cell field. In the 80's I had the fantastic opportunity to work as post doc with Darwin. #ismb

[Cedric Blanpain @CedricBlanpain]

Delighted to share our publication in @nature, where we uncover the mechanisms regulating skin cancer formation in living animals. Congratulations to @BansaccalNordin, the first author, who put all his passion into making this project a great success https://t.co/5SUSUrUN6a

[Cell Metabolism @Cell_Metabolism]

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice https://t.co/G8St8R3Ch2

[Jeffrey H. Miner @JeffMinerPhD]

Collagen Rules! More proof from Ali Gharavi’s Homer Smith Award lecture. So well deserved!

[Hironobu Fujiwara 藤原裕展 @HiroFujiwara]

Our preprint"Col4a2-eGFP mouse model reveals the molecular and functional dynamics of basement membrane (BM) remodelling in hair follicle morphogenesis"is out

Collagen IV turnover influences, BM expansion, progenitor behavior & organ shape
Homo🐭 normal
https://t.co/vkZlInCAcn

[ASMB @amsocmatbio]

Our @IntSocMatBio Distinguished Investigator Awardee, the amazing and illustrious @TainaPihlajanie on #collagen XIII and XVIII