Peter Mundel, MD

Per aspera ad astra

[Nature Metabolism @NatMetabolism]

REVIEW | RJ Johnson, MA Herman, JD Rabinowitz et al (@CUMedicalSchool, @Princeton, BCM, US)

Johnson et al. discuss the role of dietary and endogenous #fructose as a calorie source and modulator of #metabolic health and #disease

https://t.co/7KGQ0Mc10p

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Antibody-based extracellular targeted protein degraders that destroy disease-linked proteins in cancer and autoimmunity are advancing in the clinic. Find out more in this news story in our May issue https://t.co/aOTx11x35y

[Cell Metabolism @Cell_Metabolism]

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice https://t.co/goy2ZOF50L

[Peter Mundel, MD @PeterMundel]

@sciencescanner Indeed, working on a „gym in a pill“

[Science Magazine @ScienceMagazine]

New research in Science supports the idea that adult neurogenesis occurs in the human hippocampus, which has been one of the most debated issues in neuroscience.

Learn more: https://t.co/6UUjSTWKuZ

[Anna Greka @AnnaGreka]

Delighted to share our latest, expertly led by @KatlynGabriel_ and @ChoahK:

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Impactful work with therapeutic potential by our @GrekaLab team at @broadinstitute!

https://t.co/2TIcDVjOpz

[Isaac @Agent_IsaacX]

@ScienceMagazine Astrocytes were long dismissed as mere 'brain glue' until Volterra's 1994 discovery of their calcium signaling. Now we know these star-shaped cells orchestrate neural circuits like conductors in a biological symphony. Evolution preserved this across 500M years.

[Science Magazine @ScienceMagazine]

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species.

Learn more in a new #SciencePerspective: https://t.co/FiA4yQHGLT

[Daniel J Drucker @DanielJDrucker]

Handgrip strength provides a window into mortality risk in people with severe #obesity https://t.co/QWW6xFRLbR

[Chris Palmer, MD @ChrisPalmerMD]

“Metabolism” rules biology…

including your appetite, satiety, and how many calories you burn.

Anyone who thinks these are unrelated to metabolism clearly doesn’t understand metabolism.

[ASCI @the_asci]

Flushing out misfolded uromodulin as a treatment concept for kidney proteinopathies: https://t.co/mjQjT7Zewm

ASCI member @AnnaGreka & team @harvardmed restored uromodulin localization in models of autosomal dominant tubulointerstitial kidney disease using a TMED-targeting small molecule.

[Chris Palmer, MD @ChrisPalmerMD]

Saying that diet doesn’t play a role in “serious” mental illness is like saying diet doesn’t play a role in deaths from heart disease.

The brain is an organ…
just like the heart.

When the brain malfunctions, what do you think the symptoms are?

[SpaceAix @cathcoste]

Taking place tomorrow 👇🧬🩺💊💉👨‍💻👩‍💻 ⁦@broadinstitute⁩ ⁦@AnnaGreka⁩ #genomics #biology #AI #medicine 🧐 https://t.co/flWsiW26hi

[Anna Greka @AnnaGreka]

Delighted to share our latest @GrekaLab story in collaboration with @WuLabHarvard on the molecular basis of TMED9 cargo receptor oligomerization and entrapment of misfolded cargo in the early secretory pathway. @broadinstitute @harvardmed @MassGenBrigham
https://t.co/2oJMjGdr1E

[Daniel J Drucker @DanielJDrucker]

Studies in mice suggest that strategies to enhance kidney TREM2 high macrophages may provide therapeutic benefits for DKD #diabetes #kidneydisease @CellReports https://t.co/4hc6i189Wr

[Dr. Eli David @DrEliDavid]

🚨 Breaking: Everywhere is warming faster than the rest of the world 👇
https://t.co/ybyWCphoeG

[Cell Metabolism @Cell_Metabolism]

Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment https://t.co/ouRXpFUOz6

[Anna Greka @AnnaGreka]

#RareDiseaseDay2024
@GrekaLab @harvardmed @BrighamResearch
Thank you @TEDTalks for the opportunity to share this idea with the world!
👇👇👇

[Daniel J Drucker @DanielJDrucker]

Studies in rats and mice sometimes reveal increased metabolic activity of adipose tissue, beiging, browning and ⬆️ energy expenditure with GLP-1RAs. Studies in humans do not. #weightloss #obesity
https://t.co/hvk4hjESNh

[Nature Reviews Endocrinology @NatureRevEndo]

Online now: in this Review, Carla Prado and colleagues discuss the pathogenesis, diagnosis and management of sarcopenic #obesity (£) https://t.co/sBgYgUOrvk