Ryan Clarke

Founder, CEO, CTO @ Syntax Bio

[Science Magazine @ScienceMagazine]

"There is perhaps no stronger evidence of the [Trump] administration’s objectives to reduce the quality of the US scientific workforce than its treatment of the National Science Foundation’s flagship Graduate Research Fellowship Program," writes H. Holden Thorp in a new #ScienceEditorial. https://t.co/KLnLCQxDDP

[Ryan Clarke @RECdomain]

@grok @feisty_mom_wife @44NNNNNNNN @alex2yc @grok can you please provide stats on how many MAGA accounts versus Democrat accounts are foreign based

[Nick Mark MD @nickmmark]

This will be absolutely devastating in the medical field.

~30% residents are international medical graduates & ~10k of 43k residency spots are filled by docs with H1-B visas.

Previously the h-1B fee was <$5,000.

No hospital will pay a $100k fee for a $55k resident salary.

[David R. Liu @davidrliu]

David Baltimore (March 7, 1938 – September 6, 2025). His discovery of reverse transcriptase, along with Howard Temin and Satoshi Mizutani, illuminated the retrovirus life cycle, led to the discovery of viral oncogenesis mechanisms and antiviral RT inhibitors, and enabled technologies including RT-PCR, RNA-seq, and prime editing.

https://t.co/MSK81W7MBn

[Ryan Clarke @RECdomain]

@DBeardedGOAT @krassenstein Holy shit you are an idiot lol

[Ryan Clarke @RECdomain]

@_JasonCorso_ @NickelBagsArt @NIH THIS

[Ryan Clarke @RECdomain]

@bourbon_rox @DrJennyReese @NIH maybe they should also take away the medicines you rely on that came out of government funded academic laboratories

[Ryan Clarke @RECdomain]

The story behind how Generation 3.0 proGuides were engineered. They enable efficient, multi-step, pre-programmed CRISPR activation of endogenous genes.

https://t.co/X2vXk1hWdF

[Ryan Clarke @RECdomain]

Thank you for the great article ⁦⁦@medcitynews⁩ https://t.co/twT3sj4aep

[Tom Ellis @ProfTomEllis]

The pioneer of DNA assembly
EcoRI + DNA ligase* = the first recombinant plasmid

[Martin Pacesa @MartinPacesa]

Very excited to see our work on Cas9 conformational activation out in @Nature ! https://t.co/lN52efWKxd
What started as a very poor crystal structure back in 2017 in the @MartinJinek lab, turned into a full blown cryoEM project during the pandemic.

[Massimo @Rainmaker1973]

Here's a bacterium on a diatom on an amphipod on a frog on a bump on the log in the hole in the bottom of the sea [source, read more: https://t.co/qZ6x2VucHd]

[Robert Nelsen @rtnarch]

Why cell therapy is so cool.

[Ryan Clarke @RECdomain]

Thank you @tool for spending 1,227 minutes with me this year on @Spotify. You are my #1. #SpotifyWrapped https://t.co/CvUdqfbOQF

[Eric Topol @EricTopol]

Video of #SARSCoV2 infecting brain cells (gray blobs) with cell fusion, hijacking, and explosive release of copies for more invasions
https://t.co/H4BI6esouA @NYTScience @AndrewJacobsNYT by @aicher_sophie and @Delphine_Planas @institutpasteur @justsaysinrats @NikonSmallWorld

[Ryan Clarke @RECdomain]

Our paper is officially out in the latest issue of @MolecularCell

[Molecular Cell @MolecularCell]

Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities https://t.co/iPHues77gE

[Molecular Cell @MolecularCell]

Read the latest issue https://t.co/iMRlOEjqVV

[Molecular Cell @MolecularCell]

Online Now: Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities https://t.co/9XGLzSdtMe

[Florian Krammer @florian_krammer]

No words needed. That's what vaccines do.

[Ryan Clarke @RECdomain]

Incredible work!

[Sam Sternberg @shsternberg]

Massively proud of Leo's elegant & thorough study out in NBT, developing CRISPR-transposons for high-efficiency & high-fidelity DNA integration in diverse bacteria. Lots of exciting ideas on advancing this even further, together w/ collaborators @harriswangnyc and @RondaCarlotta