New paper out in @CellStemCell . We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. https://t.co/YftwM1ZkMX
Another Resource developed by @josh_brickman and colleagues presents a reference tool (https://t.co/sCKBDMEYsp) based on deep learning models for unbiased annotation of preimplantation embryo datasets.
https://t.co/uAPlpRUSLs
World-first breakthrough! reNEW Melbourne researchers at @MCRI have created lab-grown blood stem cells resembling those in the human body. This could pave the way towards personalised treatments for blood diseases such as leukemia & bone marrow failure. 🔗 https://t.co/yjLj5rVMvV
Read more: https://t.co/5pUTbOFdxD
Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of tissue is critical to tissue repair development https://t.co/Nywia4Ha9j @NatRevNeph@reNEW_Global
@twitt_login Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of the tissue is critical to tissue repair and organ development.…https://t.co/Nywia4GCjL
@Niels_Geijsen and Frank Staal are part of a project aiming to transform Cell and Gene Therapies. The project has been awarded €10M through the IPCEI Med4Health program and is a collaborative effort between @NecstGen , @NtransTech, @LUMC_Leiden and @divvly.
https://t.co/DwXCqeafgk
Terrific Nature paper that will greatly improve the analysis of spatial transcriptomic data!
Working on this as an editorial advisor was a blast, and more publications are coming!
I'm sure @KSusztak@HumphreysLab will like it, as well as @10xGenomics
https://t.co/qFPConx969
COL4A3 and COL4A4 pathogenic variants in the normal population: redefining Alport syndrome?
By Judy Savige
✏️@drvt87#ERA24#SoMe team
💥Time to change from Alport syndrome to Alport spectrum!!
⚡️ XL- kidney failure in males and 20% of females by the age of 60
⚡️ AR-kidney failure in males and females
⚡️ Digenic Alport syndrome
⚡️ AD-haematuria; kidney failure is uncommon
Presented at #ERA24:
In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: https://t.co/S6wvGwoQqB
New work from the @RabelinkT lab shows that a cell-free nutrient-supplemented perfusate allows 4-day ex-vivo preservation of human kidneys using spatially resolved lipidomics and metabolomics, @LUMC_Leiden, @reNEW_Global
https://t.co/om4aWopwdl.
Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. https://t.co/gN27A13npx
International consensus statement published in @NatRevNeph calls for urgent action to address CKD on the global public health agenda. Read “Chronic Kidney Disease and the Global Public Health Agenda: An International Consensus” ➡️ https://t.co/KkduChEqQg