ton rabelink

Professor of Medicine, Leiden University Medical Center

[Jan Żylicz @JZylicz]

Check it out if you are interested in how metabolism regulates epigenetics and cell fate. Should also be relevant to some of the cancer folk.

[Jan Żylicz @JZylicz]

New paper out in @CellStemCell . We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. https://t.co/YftwM1ZkMX

[ton rabelink @RabelinkT]

Spatial Metabolomics Reveals Lasting Stroke Brain Changes https://t.co/mKkD7F6gDU

[Nature Methods @naturemethods]

Another Resource developed by @josh_brickman and colleagues presents a reference tool (https://t.co/sCKBDMEYsp) based on deep learning models for unbiased annotation of preimplantation embryo datasets.

https://t.co/uAPlpRUSLs

[reNEW @reNEW_Global]

World-first breakthrough! reNEW Melbourne researchers at @MCRI have created lab-grown blood stem cells resembling those in the human body. This could pave the way towards personalised treatments for blood diseases such as leukemia & bone marrow failure. 🔗 https://t.co/yjLj5rVMvV

Read more: https://t.co/5pUTbOFdxD

[ton rabelink @RabelinkT]

Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of tissue is critical to tissue repair development https://t.co/Nywia4Ha9j @NatRevNeph @reNEW_Global

[ton rabelink @RabelinkT]

@twitt_login Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of the tissue is critical to tissue repair and organ development.…https://t.co/Nywia4GCjL

[reNEW @reNEW_Global]

@Niels_Geijsen and Frank Staal are part of a project aiming to transform Cell and Gene Therapies. The project has been awarded €10M through the IPCEI Med4Health program and is a collaborative effort between @NecstGen , @NtransTech, @LUMC_Leiden and @divvly.
https://t.co/DwXCqeafgk

[nature @Nature]

Nature research paper: Bridge RNAs direct programmable recombination of target and donor DNA https://t.co/PKpLG7xZR4

[Josh Brickman @josh_brickman]

Latest in our Plasticity Project, featuring our fave cells, Primitive Endoderm (PrE), and their in vitro model, nEnd. Amazing PhD journey @MLAgerhom, contributors @AnnikaCharlott2 @albooo87 @MartaPrera @mproksik @TeresaKnudsen @MigManzanares (1/11). https://t.co/sXhlxmUMnX

[ton rabelink @RabelinkT]

@josh_brickman @AnnikaCharlott2 @albooo87 @MartaPrera @mproksik @TeresaKnudsen @MigManzanares fantastic!

[Rosalie Rietjens @RietjensRosalie]

Our review “Spatial metabolomics in tissue injury and regeneration” is now available online!

https://t.co/LFhswh6HDG

[Michele Marass @MicheleMarass]

Terrific Nature paper that will greatly improve the analysis of spatial transcriptomic data!

Working on this as an editorial advisor was a blast, and more publications are coming!

I'm sure @KSusztak @HumphreysLab will like it, as well as @10xGenomics
https://t.co/qFPConx969

[ERA - European Renal Association @ERAkidney]

COL4A3 and COL4A4 pathogenic variants in the normal population: redefining Alport syndrome?

By Judy Savige
✏️@drvt87
#ERA24 #SoMe team

💥Time to change from Alport syndrome to Alport spectrum!!
⚡️ XL- kidney failure in males and 20% of females by the age of 60
⚡️ AR-kidney failure in males and females
⚡️ Digenic Alport syndrome
⚡️ AD-haematuria; kidney failure is uncommon

[NEJM @NEJM]

Presented at #ERA24:

In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: https://t.co/S6wvGwoQqB

[nature @Nature]

Researchers have mapped a tiny piece of the human brain in astonishing detail https://t.co/TDXUDbIE87

[Nature Communications @NatureComms]

New work from the @RabelinkT lab shows that a cell-free nutrient-supplemented perfusate allows 4-day ex-vivo preservation of human kidneys using spatially resolved lipidomics and metabolomics, @LUMC_Leiden, @reNEW_Global
https://t.co/om4aWopwdl.

[ton rabelink @RabelinkT]

Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. https://t.co/gN27A13npx

[ton rabelink @RabelinkT]

@Boletta_Lab @ERC_Research congratulations!

[Int Society of Nephrology @ISNkidneycare]

International consensus statement published in @NatRevNeph calls for urgent action to address CKD on the global public health agenda. Read “Chronic Kidney Disease and the Global Public Health Agenda: An International Consensus” ➡️ https://t.co/KkduChEqQg