Chris V

I study mechanisms of gene reg. and reg. variants using integrative genomics and HT reporters. Views are my own.

[Amanda Elliott @AmyIsMyNickname]

🎉 Our #GWAS of gestational diabetes in #FinnGen is now available on medrxiv! We disentangle the genetic relationship of GDM with Type 2 diabetes using new methods we think could be much more broadly useful.
A brief thread 🧵 1/7
https://t.co/VEJISlCyXX

[Jorge Diego Martin-Rufino @jmartinrufino]

Just out!! Excited to see published our manuscript with @anikagupta18 on the inference of regulatory relationships from stochastic transcriptional variation. Huge thanks to our mentors and all the coauthors!! https://t.co/0RyTMT6rNr

[Matan @matanhofree]

We are excited to share our study on spatially organized multicellular immune hubs in human colorectal cancer https://t.co/tzJxdLaLTn @CellCellPress. Joint effort with @karin_pelka, @chenchirps, @AnaAndersonlab, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen, many others!

[Charles Gersbach @cgersbach]

We're very happy to see this published with the hope that others will be able to use these models to study function and regulation of their favorite genes and noncoding elements. Mice are available at Jax: https://t.co/9ZqSHwaIsg https://t.co/8flLbT9MGj

[Broad Institute @broadinstitute]

We’re excited to introduce #HCRFlowFISH, a new method for characterizing the function of gene regulatory elements developed by @ReillyLikesIt, @r_tewhey, @SagerGosai, @PardisSabeti and colleagues. Now in @naturegenet; some highlights below. https://t.co/zw3N3fnsOF 1/6

[Chris V @RegulatoryDNA]

@neuron81 @EinsteinMed @ae_cancercenter @bloodgenes @Zfish_Blood_Lab @pnatarajanmd @leonard_zon @Agarwal_Lab Congrats!

[Xiaole Shirley Liu @XShirleyLiu]

Congrats to the team on the comprehensive CHIPS pipeline built on Snakemake for batch processing of bulk ChIP/ATAC-seq samples, runs on servers, AWS and GCP, and is especially useful for core facilities and our Cistrome data collection efforts.

[Rasim Barutcu @rassobar]

Very nice overview of different types of loops by Solovei and @leonidmirny. Keeping chromatin in the loop(s): https://t.co/WTmYrO76N3 @NatRevMCB

[bioRxiv @biorxivpreprint]

Cohesin is required for long-range enhancer action https://t.co/iMFrowCddb #bioRxiv

[Chris V @RegulatoryDNA]

@ReillyLikesIt @YaleGenetics @YaleMed Congrats, Steve and congrats to @YaleGenetics on recruiting another truly outstanding scientist. Looking forward to great things.

[Steve Reilly @ReillyLikesIt]

Excited to announce I’m joining @YaleGenetics, with the https://t.co/bfBIF7CJfB starting fall ‘21! I’m also eager to contribute to the human genomics community at #YaleCenterforGenomicHealth and @YaleMed! Now for a long list of thanks to all the folks who enabled this moment:

[Chris V @RegulatoryDNA]

@timreddy @GrahamD_Johnson @EncodeDCC Fantastic!

[Des Higgins Official @HigginsDes]

I've been very lucky. I've had 33 years of Clustal (1,2,3,4,V,W,X and Omega). Omega is the last letter of the Greek alphabet and I joked in 2011 that it would be the last one. It is. I'm out of funding and kind of relieved. Thanks folks!! It's been a blast ;-).

[Michael Makris @ProfMakris]

Amazing case report. The medicine of tomorrow. 5 week old boy admitted to NICU. Within 37 hours he had his whole genome sequenced, gene defect identified, treatment ordered and received by patient. Within 6 hr symptoms resolved. https://t.co/UYSJSURQHW

[Jenny Tung @jtung5]

Happy to share a new lab preprint from @MostlyMammals! We use data from @AmboseliBaboons to investigate the relationship between social status (in M and F) and social bond strength (in F) on immune cell gene expression. https://t.co/jrRCFlej8V (1/6)

[Débora Sobreira @Sobreira_DR]

Obesity-associated variants within FTO mediate disease risk through brain (Smemo, 2014) or adipose (Claussitzer, 2015) phenotypes?
Both!
How?
Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5
Now out at Science: https://t.co/pnWgd6bcGf

[Ayshwarya Subramanian @ayshwaryas]

Excited to share the results of a huge collaborative effort @broadinstitute @brighamWomens providing comparative cellular taxonomies of human and mouse adult kidneys using #scRNAseq . We studied the healthy, obese & diabetic kidney to ID shared cell states across species 1/

[Hanneke Vlaming @HVlaming]

So proud and excited to share with the world what I’ve been working on for the last years! I developed the INSERT-seq method to study the effect of transcribed sequences on transcription and its output, screening thousands of integrated seqs in high-throughput! (1/n)

[Chris V @RegulatoryDNA]

Exciting new work from @jraylab and @r_tewhey!
https://t.co/HyszTH7hEZ

[Chris Cotsapas @ccots]

After close to a decade of wrangling, our cross-disease paper is finally done! https://t.co/jXcPXZT4P8