Rob Sheko

Life is coming from you, not at you.
Prev Developmental Bio @Harvard.
Current grad student @Columbia

[Alex Plesa @amplesa]

Most of the cells in your body are younger than you are. Yet, you still age. Why?
I explore this in my new post. Link in the reply.

[Elon Musk @elonmusk]

@FischerKing64 Longevity is coming

[Rob Sheko @RobSheko]

@agupta Coming to NYC/Columbia anytime soon?

[Rob Sheko @RobSheko]

@adic_9 Which tests are you thinking of that are that expensive? I haven’t seen anything nearly that expensive for immune monitoring

[Rob Sheko @RobSheko]

Paper: https://t.co/Sjj3bvIK5G

[Rob Sheko @RobSheko]

Yet another fun aging paper: taurine levels increase with age. Does that make taurine pro-aging? No, in fact adding EVEN MORE taurine extends healthspan

[Rob Sheko @RobSheko]

@mrsbiosingular @techno0ptimist Highly recommend freezing the placenta! It has mesenchymal stem cells which are very potent. Cord blood mostly has blood stem cells and mscs are a different lineage/use case. Probably won’t get enough mscs from blood alone for viable usage down the road

[Rob Sheko @RobSheko]

Really cool to see this going mainstream! I froze several of my own cell lines years ago, including some iPSCs. It’s one of the highest leverage bets you can make for your future health. We’ll be able to regrow tissues and failing organs at some point as regenerative medicine advances. The bottleneck then becomes: where do you get the cells from? The best source is always going to be your own cells, and the best time to freeze those cells is as young as possible before damage and mutations accumulate.

[Dr. Nabiha Saklayen @nabihasaklayen]

In partnership with Vinod Khosla (@vkhosla), I’m proud to introduce Reservoir.

Billionaires have owned their cells for years. Starting today, you can too.

Sign up today: https://t.co/JftHvfPx6A

[Rob Sheko @RobSheko]

@alysoncogene @rinadwithanr Very cool. Lots of great research here!

[Aly @alysoncogene]

Rinad (@rinadwithanr) and I wrote an essay about iron deficiency!

It came out of a broader project we’ve been working on surrounding “low-hanging fruit” in improving general health and wellbeing. The problems we’ll address impact many people and their quality of life. In many cases, they tend to be measurable, treatable, and strangely under-served or neglected by the broader healthcare system.

Iron deficiency really stood out here, particularly in women. It’s incredibly common, can affect how you feel and function well before you’re technically anemic, and yet often isn’t caught because routine bloodwork doesn’t actually measure iron stores. (Lately, we’ve been seeing a lot of discussion re: iron deficiency on Twitter, and I’m glad more people are talking about it!)

We looked at how iron deficiency actually works, why ferritin matters, how prevalent it is, what the evidence says about its effects on fatigue, cognition and physical performance, why it so often goes undetected, and what the evidence says about treatment.

This is the first piece in a larger body of work we’re developing on overlooked-yet-surprisingly-tractable problems in health—particularly in women’s health, longevity, and quality of life. More coming soon!

In the meantime, get your ferritin checked and read what we’ve put together. Substack link below!

And if any of this is an area you’re working on or thinking about, DM me or Rinad—we’d love to discuss :)

[Rob Sheko @RobSheko]

A good friend group is like a mini breakaway civilization

[Rob Sheko @RobSheko]

@yzyupdates The Greeks spoke of this

[Eric Topol @EricTopol]

We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
https://t.co/iw1ceSbUvf

[Sterling Cooley @SterlingCooley]

Careful out there - some accounts are getting phishing attacks asking you to vote for them and you can “conveniently” vote with your X account

(Requiring you to login with your password to a X clone)

Bam, phished, account gone

Stay frosty 🥶 folks

[Rob Sheko @RobSheko]

Genetic medicine is creating a whole new frontier for aging interventions. Excited to have coauthored a piece here alongside many of the field's top figures. We cover how gene editing, RNA silencing, epigenome modification, and engineered cell therapies can be used to close fundamental gaps in our biology and address problems no intrinsic pathways can solve.

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

IT'S OUT. 🎉

FRONTIERS OF LONGEVITY SCIENCE @SpringerNature

Leading scientists, clinicians, and entrepreneurs on where the field stands, and where it will go.

Science today. Longevity tomorrow. 🚀

Like and repost to help it travel!👇👨‍⚕️

🔗https://t.co/sicZ7asaZz

[Rob Sheko @RobSheko]

@peter_ackerson @jeffgiesea @STASchoolDC They do indeed still do it

[Rob Sheko @RobSheko]

@jamessinka @ReactorfieldAI @berkbuilds Loooks 🔥🔥

[Rob Sheko @RobSheko]

@aj_dev_smith Love it thanks!