Stefan Holderbach

Molecular Biotechnology @UniHeidelberg | #bioinformatics #proteins #synbio #ML @nu_shell | formerly @HITStudies @DKFZ @iGEMHeidelberg

[Jan Mathony @JanMathony]

Interested in allosteric protein switches? Check our ProDomino - our new model for the prediction of domain insertion sites. With ProDomino we engineered several potent inducible proteins including Cas9 and Cas12a variants.
https://t.co/0y1829s5lq

[Kerstin Göpfrich @KGoepfrich]

Origami + Genome engineering = PICasSO! Best of luck to the @UniHeidelberg @iGEM team. Find out more about PICasSO here: https://t.co/XRTJvnLd2X

[Stefan Holderbach @SHolderbach]

Programming late into the night is not ruining my sleep pattern...

that's vimsomnia

[Kortemme Lab @KortemmeLab]

We’re thrilled to share our new pre-print exploring how we can design and control dynamic proteins! (1/6) https://t.co/w7sRsdJV9y

[Stefan Holderbach @SHolderbach]

Great ad for positions, in this GPU economy!

[Jan Kosinski @jankosinski]

Two 🔥 computational postdoc positions 🔥are available in our lab, funded by @ERC_Research ! https://t.co/O2YGVh6x1g and https://t.co/ym8PQ5r1lq. Join us and unleash the power of these just-delivered beasts 👇And please repost to help us!

[Stefan Holderbach @SHolderbach]

@reillywood NoSQL with json in S3 sounds like a 90 ms approach to me

[Stefan Holderbach @SHolderbach]

And for folks wanting to take a look at the code... oh wait:

[Stefan Holderbach @SHolderbach]

wake up, new kind of preprint(?!) just dropped #AlphaFold

[Stefan Holderbach @SHolderbach]

For the folks wanting to take a look at the actual paper: https://t.co/lxbnHBJ7zA

[Stefan Holderbach @SHolderbach]

Sharing because it is great and no particular other reasons:

[Simon Duerr @simonduerr]

I have created Bioicons - a library of 1632+ free, high quality science illustrations in vector format easily searchable and filterable specifically for the life science community. All icons are under permissive CC0 or CC BY license. ➡️ https://t.co/H7CawgOOiJ

[Stefan Holderbach @SHolderbach]

New open source occupational hazard: RSI from manually deleting @github action caches

[Stefan Holderbach @SHolderbach]

@reillywood You are right, the things to reset can be reset tolerating errors (not supported by the terminal/not enabled before) in a panic hook if you are the application author. For a library like reedline, we either provide the Drop or need to doc that you should call a helper in the hook

[Stefan Holderbach @SHolderbach]

@KevinKaichuang The beloved "int53"...

[Stefan Holderbach @SHolderbach]

@Euphrasiologist @nu_shell @devynci Yes! You can stream and the plugin can be kept alive between calls to it so it can hold its resources in its own memory.

[Stefan Holderbach @SHolderbach]

"we were just looking at the active site of the protein. (...) It is famous for its 123 angstrom spike"

[Geordi Frere @geordifrere]

Is it me or is the distinction between SuFEx/PFEx click chemistry and just straight up nerve agents getting worryingly blurred 😬

[Andy Gayton @cablelounger]

The @nu_shell community has strong momentum. 0.91 introduces @devynci's work on streaming data into and out of plugins.

This enhancement enables the creation of plugins that can parse a stream of HTTP server-sent events, for example

https://t.co/fkK43BYzv4

[Stefan Holderbach @SHolderbach]

Orchestrion with a viola in the center
- designed by committee
- we should clarify this is not a violin
- individual parts make sense, but why?
- automation that hides a ton of mechanical complexity

=> C++
14/x

[Stefan Holderbach @SHolderbach]

I see, programming twitter was having a normal one around language choices.

To contribute seriously to this discussion, a thread on programming languages as musical instruments: 1/x

[Stefan Holderbach @SHolderbach]

Harmonica
- easy to pick up some basics
- highly portable, you can play it basically anywhere
- probably inappropriate in a bunch of circumstances

=> JavaScript
13/x