Safavi Lab

Exploring and developing applications of biomedical peptides from marine venoms | Tweets by lab members. #conesnails #venom 🇩🇪🇵🇭🇩🇰🇭🇰🇺🇸🇫🇷🇦🇺

[Safavi Lab @SafaviLab]

Another news piece on why cone snail venom is an untapped source of drug discovery. Thanks for covering our studies!

[ScienceNews @sciencenewsdk]

A deadly sea snail has evolved a unique method of hunting that uses insulin-like compounds as a biological weapon. Research reveals that the geography cone snail releases a mix of mimic molecules into the water, altering its prey���s #metabolism and inducing a state of stupor. This nirvana cabal contains potent #toxins, including compounds that inhibit glucagon, explaining the prey’s inability to raise blood #glucose. These insights may pave the way for novel #treatments for metabolic disorders and enhance imaging techniques for diagnosing #cancer, showcasing the potential of these natural compounds in advancing #medicine.

#sciencenewsdk @SafaviLab

Read more: https://t.co/3B9l1LCTS9

[Safavi Lab @SafaviLab]

A very nice piece covering our story on the unusual glucose-lowering hunting strategy used cunningly by the fish-hunting cone snail, Conus geographus. Check it out!

[The Scientist @TheScientistLLC]

Cone snails in the tropical waters of Palau have a secret weapon.

Researchers (@UUtah) found that one cone snail deploys insulin- and somatostatin-mimicking toxins that crash fish blood glucose levels.
https://t.co/ld4XN3FDMU

[Safavi Lab @SafaviLab]

A great cover story in @nytimes magazine showcasing how venomous animals provide ingenious solutions to solve some of the long-standing problems in drug development.
It was great showing Kim our cone snail aquarium, and our exciting research.
https://t.co/63GfS5pSfA

[Safavi Lab @SafaviLab]

Another example of why cone snails are rich drug source! Another great collaboration with the Toto Olivera lab at @UUtah

[Jortan Tun @JortanTun]

Cone snails produce χ-conotoxin to hunt other snails. These toxins are potential anti-pain drugs.

Funtastic work from Sam Espino and collaborators of the Olivera Lab! https://t.co/z6yQ3oX3z3 #ConeSnails #conotoxin #venom

[Julie Kiefer @JulieCKiefer]

"What do online grocery shopping, venomous snails, and foot biomechanics have in common?"

Find out!

Largest-Ever @UofUDMRC @UofUHealth Retreat Tackles Problems from Public Health to Drug Development https://t.co/D49jG9MPo4

[Safavi Lab @SafaviLab]

Don’t miss out on this seminar featuring our very own Dr Thomas Koch!

[Ronald Jenner @evolriffs]

Join us on 9 October at 5pm CET for a new EUVEN seminar featuring Thomas Koch discussing cone snail venom evolution, and Schyler Ellsworh discussing mechanisms of venom resistance in flies. Register at https://t.co/IQRttsrB41 @Schy_Ellsworth @LundKoch

[Safavi Lab @SafaviLab]

Great opportunity to work in a great lab with a great mentor!

[Walden Bjørn-Yoshimoto @waldensciencing]

Interested in #pain #pharmacology and structural biology and looking for a master's thesis project in Copenhagen?

Read here to see more and apply for an intriguing project:

https://t.co/PboGBeavf6

[Safavi Lab @SafaviLab]

Helena gave a stellar tenure talk today, drawing different examples of prey-hormone mimicking, doppelgänger toxins found in cone snail venoms!

[U of Utah Dept of Biochemistry @UofUBiochem]

On Thurs Sept 12, Helena Safavi @SafaviLab will give her tenure talk entitled "Insights from the Biology, Behavior, and Evolution of Venomous Animals for Drug Discovery." 12pm at HSEB Alumni Hall!

[Safavi Lab @SafaviLab]

Many thanks also to @EivindUndheim and @PoulNissen for being amazing PhD assessors!

[Safavi Lab @SafaviLab]

Proud to present our newly minted Dr Sophie PhD of the Safavi lab! 🐚🎓🎈🎉🎊 very well deserved for all her hard work! Also nice to see past members of the Safavi lab in Copenhagen!

[Safavi Lab @SafaviLab]

What a great time at Yellowstone 🌋with @StingScience, @waldensciencing, @LundKoch, @yeung_hyw, @irisbeara and other amazing people (Lars, Celeste, Vanessa) from 🇩🇰🇦🇺who are not on the X universe. Looking forward to your next visit in Salt Lake City!

[Safavi Lab @SafaviLab]

@LairmoreDVMDean @OneHealthUCD @onehealth_csu There are surely yet more nature's secrets to be unveiled. Thank you for your interest in our work!

[Safavi Lab @SafaviLab]

@SimoneCappelli6 Very much agree! Thank you for mentioning our work!

[Safavi Lab @SafaviLab]

@ChrisStringer65 Thank you so much for noticing our work!

[Safavi Lab @SafaviLab]

@dr_muniyappa thank you so much for your interest in our work!

[Molecular Biology and Evolution @MolBioEvol]

Be sure to check out the full article by @SafaviLab @LundKoch @UofUBiochem: Prey Shifts Drive Venom Evolution in Cone Snails https://t.co/swLNAUH2qq

[Safavi Lab @SafaviLab]

@CoskunPLID thank you!

[Safavi Lab @SafaviLab]

@DanielJDrucker @NatureComms thank you for mentioning our work!

[Safavi Lab @SafaviLab]

🧵5/5 Special thanks to @janetiwasa for creating this wonderful animation!

[Safavi Lab @SafaviLab]

Excited to share our latest story on how fish-hunting cone snail uses a combination of weaponized insulin and somatostatin-like toxins to disrupt glucose level in its fish prey 🐚⚡️🐠🍬
Check out our paper and animation to learn more:
https://t.co/ftJeIJK5dU @NatureComms 🧵1/5

[Safavi Lab @SafaviLab]

🧵4/5 This work is led by @yeung_hyw, @irisbeara, @LundKoch and @waldensciencing from our lab. Also amazing collaborations from groups at UCPH @UCPH_health 🇩🇰@Alphacell_metab, @H_Brauner, @kattesch, Jens Juul Holst and Toto Olivera's lab at the U of Utah 🇺🇸 @UUtah @UofUBiochem!