Samantha Zepeda

[The Veesler Lab @veeslerlab]

Can we leverage recent developments in machine-learning & protein design to tackle previously intractable challenges?

The answer is yes and we show it in this study led by the one and only @Dr_MattMcCallum

@HHMINEWS
@UWBiochemistry

1/9

https://t.co/rOMv0cBuyf

[The Veesler Lab @veeslerlab]

Are you passionate about designing vaccines against viruses and understanding how they work at the molecular level? We're hiring! Join our innovative and fun team to do science that changes the world. Please RT

@HHMINEWS
@UWBiochemistry

[Samantha Zepeda @Sam_K_Zepeda]

So grateful for the opportunity to share my work on bat borne Sarbecoviruses at the Rising Stars symposium @UofUBiochem. Excited to hear all the other amazing work being done!

[Tyler Starr @tylernstarr]

Looking forward to meeting everybody at our @UofUBiochem @uofunuip third Graduate Student Rising Stars Synposium! All Utah colleagues, come and enjoy some exciting science and good times.

[Cell Host & Microbe @cellhostmicrobe]

Receptor tropism & immunogenicity of bat-borne sarbecovirus. @veeslerlab @0327jimin @Sam_K_Zepeda show PRD-0038 clade 3 sarbecovirus has broad ACE2 usage. ID cross-neutralizing Abs & show PRD-0038 spike elicits more broadly reactive Abs vs #SARSCoV2 spike https://t.co/3ZZqwHGJ79

[The Veesler Lab @veeslerlab]

Delighted to share the peer-reviewed version of our article investigating bat-borne sarbecovirus interactions with ACE2 host receptors and implications for pandemic prepardness!

Led by @0327jimin & @Sam_K_Zepeda

https://t.co/aDNQE0Gtsn

[The Veesler Lab @veeslerlab]

How do bat-borne sarbecoviruses (i.e. SARS-CoV-1/2-like viruses) interact with host receptors and are we ready for a possible future pandemic?

Find out in this study led by @0327jimin & @Sam_K_Zepeda !

@HHMINEWS @UWBiochemistry

1/23

https://t.co/HGG3V2turi

[Tyler Starr @tylernstarr]

There's also a nice write-up of the story from Sabrina Richards @fredhutch! https://t.co/F9euApaUCd

[The Veesler Lab @veeslerlab]

Can we correlate #SARSCoV2 spike (S) biochemical properties with the specificity, magnitude & quality of antibody responses? Put another way, how to make a good #CovidVaccine ?

@johnbowenbio led the charge to answer these questions

@HHMINEWS

1/21

https://t.co/vonzUbI10I

[The Veesler Lab @veeslerlab]

We characterized the structural basis of #SARSCoV2 #OmicronVariant binding to the host ACE2 receptor and neutralization by the S309/sotrovimab clinical antibody therapeutic!

Led by @Dr_MattMcCallum & Nadine Czudnochowski Collab w Gyorgy Snell

1/8

https://t.co/hLNqmmLmJ7

[nature @Nature]

Nature research paper: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift https://t.co/LXL1X5Dppn

[The Veesler Lab @veeslerlab]

Our manuscript on eliciting broadly protective sarbecovirus immunity using mosaic nanoparticle RBD vaccines has been peer-reviewed and can be found here
@coronalexington led this collaboration with @KingLabIPD and many others

1/3

https://t.co/6lGE7pOjVi

[Samantha Zepeda @Sam_K_Zepeda]

Virus-encoded histone doublets are essential and form nucleosome-like ... https://t.co/p4ElvaHjz0

[Nature Portfolio @NaturePortfolio]

A paper in @Nature reports the characterization of a human monoclonal antibody against SARS-CoV-2 that is able to neutralize diverse sarbecoviruses, including currently circulating SARS-CoV-2 variants. https://t.co/Szm7YQhupa

[Tyler Starr @tylernstarr]

Excited to share our preprint demonstrating that ACE2 binding is a deep ancestral trait of sarbecoviruses with plastic evolutionary potential. A fun collaboration with @jbloom_lab @veeslerlab @SamK_Zepeda @coronalexington @AllieGreaney https://t.co/ELkDDVrhPw 🧵👇