Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸

Scientist, personal chef and serial complainer. All opinions my own.

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

@UlijnGroup Is that the light box studio I bought that no one used for years?!

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

Check out my tutorial article on processing high-throughput dose-response data using a Python library I authored.

Google Colab - https://t.co/QRTlozMpTB

https://t.co/6RWYvmaUZg

[Danielle Swingle @daniswingle]

Hi! I’m a biochemistry PhD candidate at CUNY seeking a European-based postdoc position. I want to apply my structural bio skills (protein purification, NMR, MS, xtallography) to Origin of Life research. If you know of anything, please DM or email me: [email protected]

[Tamir Gonen @gonenlab]

Structure of a novel enzyme used everyday In laboratories around the world. It doesnt express well so structure by Xray was not possible. However, tiny amounts of material gave nanocrystals and #MicroED delivered a structure using a single nanocrystal

https://t.co/Tm6JuE6N29

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

ICYMI: PDB Entries with Novel Ligands Now Distributed Only in PDBx/mmCIF and PDBML File Formats
First 5-character ligand has been released: https://t.co/hyix7UNiGL
Details: https://t.co/J3n5lItu79

[Andrew Savinov @bioSavinov]

Want to design genetically encoded inhibitors of your favorite protein? Thrilled to announce our latest work w/ @SassSeabass, @keating_lab, & @GeneWeiLiLab, where we leverage massively parallel AlphaFold predictions to discover peptide inhibitors. https://t.co/1ij3s3ZkCw
(1/n)

[Sam Horrell 🗿 @DrHorrell]

Ever wondered what happens when you Fourier Transform a Peacock?

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

Another exciting preprint from the Baker group and collaborators describing de novo design of small molecule binding proteins for application in sensors using an alternative (and complimentary) methodology to their earlier diffusion approach.
#ProteinDesign

[SciencesNetwork @SciencesNetwork]

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles
https://t.co/JawzgId6jp

[Machine Learning in Chemistry @ML_Chem]

Chemprop: A Machine Learning Package for Chemical Property Prediction #machinelearning #compchem https://t.co/Ej0o5dZpcC

[Chemistry World @ChemistryWorld]

Cubane is similar in size to benzene and can be swapped into existing drugs to improve their properties through differences in bond angles and electronic structure. It’s just one of a range of strained bioisosteres that researchers are exploring.
https://t.co/fvfCDqb4TB

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

@ob_cycler There is so much space on Kearney Villa they could take out a whole lane and make a wall protected two way for cyclists. North/south options around here are “limited”

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

Excellent paper describing a method for loading nanoparticles with an API with a linker that allows environment specific release. So much scope for tuning and adaption!

https://t.co/oaGjkF2qQh

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

Oh my. Time to check and revise code in structural bioinformatics...

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

#teammassspec any suggestions on a python package to annotate an MSMS spectra using a custom fragmentation table (funky highly modified peptide)

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

@lgamon What software did you use for annotation?

[Ankit Jain @ajabsurd]

Happy to share that, starting this fall, I will be joining @bklyncollege411 @CUNY as an asst. prof.! I will be heading @syschemlab and look forward to working on various aspects of systems chemistry. A special thank you to @Ulijngroup, @SubiJGeorge, Bert Meijer, and @pkvemula!

[Systems Chemistry Lab @syschemlab]

The systems chemistry lab will be up and running this fall @bklyncollege411 @CUNY! We hope to work on finding systems chemistry solutions to proto-cellular life, novel therapeutics, and everything in between.
For opportunities: https://t.co/CAsOkrWETH.
RT appreciated.

[Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 @ScottAMcPhee]

@mcleodm @ForwardBike You’ve never cycled on this road layout. The video ends before the car driver gets frustrated (spurred on my the honking of the car behind) and forces their way through the oncoming bike traffic causing chaos.