Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. https://t.co/NEH92mQTGs
Excited to share the first part of my PhD work!
Into the SPIDR-verse! This massively multiplexed CLIP method will take your research to a multiverse of possibilities 🕷️🕸️
Many proteins bind RNA, yet we still don’t know what RNAs most RBPs bind because current methods map one protein at a time. With the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. https://t.co/BnxlSyJLfE
🔬#JobOpportunity! We're recruiting a Research Technician to join our lab @Caltech. If you are interested in working with an amazing team on #RNA, nuclear structure, and gene regulation, let's connect! #researchjobs#biologyjobs
Apply: https://t.co/YLCqURyNWY
What are the functional roles of 3D genome organization? In a new preprint led by @_prashantbhat, we demonstrate a critical role for dynamic 3D organization of genomic DNA around nuclear speckles in controlling the efficiency of mRNA splicing.
https://t.co/zWBaXr7jmy
Do specific locations in the nucleus preclude transcription? In a new paper led by @sofiquinodoz & Isabel Goronzy, we show that Pol II txn occurs throughout the nucleus, including locations thought to be inactive (B compartments & nucleoli).
https://t.co/P2Gzxcvwn7
Tell me you've never been discriminated against on the basis of race, religion, sexual orientation or disability, without telling me you've never been discriminated against on the basis of race, religion, sexual orientation or disability......
Excited to share our Comment now out in @naturemethods!
@mitchguttman and I discuss the massive regulatory potential for ncRNAs and the technical challenges faced by the field in bridging the gap between this potential and functional relevance.
https://t.co/NLtDHJg0GV
NIH peer review system is far from perfect, but it's the best I've seen. I just "retired" from the GCAT study section after 4 years' of service, which prompted me to share a few thoughts re computational proposals. These are the points that I also remind myself. Other thoughts?🧵
Play the long game:
Don't worry about being great. Worry about being great at being consistent. Small steps taken regularly over time lead to big gains.
It really is amazing how much people overestimate what they can do in a year and underestimate what they can do in a decade.
Super stoked to be joining MoGen @UofT as an Assistant Professor in Oct '22!
I'm founding "The Laboratory for RNA-Based Lifeforms" to explore the diversity of Earth's RNA entities 🧬🔎🦠🌎!
Looking to hire🥰! (Please RT)
#RNA#genetics#virology#bioinformatics
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Exciting to recruit a new postdoc position in the @Giraldezlab on research development and scientific writing. If you are interested in science administration check our job add https://t.co/3RbopOTpyn
and apply here https://t.co/9p7zR2Only