Shuai Fu

Postdoctoral Fellow at Salk Institute for Biological Studies

[Shuai Fu @ShuaiFu2]

Excited to share that the second piece of my PhD work at Wynshaw-Boris lab in close collaboration with Dr. Luke Bury is out!👉

[Cell Reports @CellReports]

Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of neuronal production, diversity, and disease https://t.co/Xy6vDi5l2R

[Shuai Fu @ShuaiFu2]

@Tech_Bioinfo @dwzhu128 you need to pay to use it

[Cell Reports @CellReports]

Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of neuronal production, diversity, and disease https://t.co/Xy6vDi5l2R

[Salk Institute @salkinstitute]

@JoeEcker, @ecallaway, Margarita Behrens, and team have produced the most detailed atlas ever of the diversity and connections of neurons in the mouse brain 🧠 Their work is featured in a 10 paper BRAIN Initiative package in @Nature #BICCN #studyBRAIN

https://t.co/nexkrb2z3o

[Mushtaq Bilal, PhD @MushtaqBilalPhD]

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[Yanjiao Li @YanjiaoLi]

It's finally out in Nature Biotechnology. https://t.co/QOSfBNSxuI We developed single cell m6A RNA modification mapping technology for studying m6A in vivo in single cells and scarce cell types without specialized laboratory equipment.

[Shuai Fu @ShuaiFu2]

Our results suggest individual progenitor subtypes play unique roles in generating the diverse neurons of the human cerebral cortex.(5/5)

[Shuai Fu @ShuaiFu2]

New preprint from Wynshaw-Boris lab, Carried out by our excellent postdoc Luke Bury and me😀, see link👉
Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of human neuronal production, diversity, and disease https://t.co/v59ylwkA2C

[Shuai Fu @ShuaiFu2]

Applying this lineage tracing in an isogenic pair of autistic iPSC allowed us to identify that an autism spectrum disorder-specific CTNNB1 stop-gain variant led to altered lineage-specific neuronal production and transcriptional differences.(4/5)

[Shuai Fu @ShuaiFu2]

https://t.co/9HOhvtBmVT

[Spectrum (Autism Research News) @Spectrum]

A new study suggests that in addition to exploring the effects of known autism-linked mutations, researchers should assess the potential mediating effects of the rest of a person’s genome. How will you use this insight in your research?

By @cqchoi.
https://t.co/fbLRehBkPt

[Spectrum (Autism Research News) @Spectrum]

@girirajan16 @ShuaiFu2

[Shuai Fu @ShuaiFu2]

@stetson_thacker @AJHGNews Thank you!!!

[Shuai Fu @ShuaiFu2]

My PhD thesis work on autism risk gene PTEN is out @AJHGNews,
Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis. Check it out! 👉
https://t.co/DrJ1Ofwm3m

[AJHG @AJHGNews]

💫 OUT NOW
@AJHGNews
📰 Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis
🧑‍🤝‍🧑
@ShuaiFu2 & team
👇
https://t.co/ADo0BSKrxY

[Shuai Fu @ShuaiFu2]

We uncovered that the PTEN p.Ile135Leu variant, found in an ASD-affected individual with macrocephaly, dysregulated cortical neurogenesis in an ASD-genetic-background-dependent fashion by using 2D neural progenitor cells and 3D cortical organoids.

[Shuai Fu @ShuaiFu2]

We performed bidirectional genome editing on iPSCs derived from individuals with autism and controls.