Sihan Wu 吴思涵

Assistant Professor @CRI_UTSW, @UTSWCancerBio @GDDgradprogUTSW @utswcancer member. CPRIT scholar @CPRITTexas. Ph.D. Molecular basis of ecDNA in human cancer.

[bioRxiv Cancer Bio @biorxiv_cancer]

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment https://t.co/UcD3xDQXdL #biorxiv_cancer

[Sihan Wu 吴思涵 @SihanSean]

Wonderful conference organized by @zz_zhaozhang @regenberg_lab @Fusion_Conf. Congrats to @stanleylim93 for the #1 best poster. And PI got awarded for his nosiness on other people’s research. Photo credits to @PeterLyLab

[Sihan Wu 吴思涵 @SihanSean]

I don't understand...Cancer researchers again need to pay to access the knowledge they create.

[Sihan Wu 吴思涵 @SihanSean]

Very proud to contribute! Emerging evidence links ecDNA with cold TME. But still chicken&egg as we don't know the mechanism yet. Stay tuned for new findings to come.

[Cancer Discovery @CD_AACR]

From the June issue: Spatial-Temporal Diversity of #ecDNA Shapes Urothelial Carcinoma Evolution & Tumor-Immune Microenvironment https://t.co/Bz5XIj6fKZ

By Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han, and colleagues

[bioRxiv Cancer Bio @biorxiv_cancer]

Accurate Prediction of ecDNA in Interphase Cancer Cells using Deep Neural Networks https://t.co/STFWBIepS1 #biorxiv_cancer

[Stanley Lim @stanleylim93]

Wu lab is 4 years old! Had our anniversary feast today at Dong Bo Sung (again! cause its good!) and 🎂 cake from Ecclesia Bakery @SihanSean @YoonKimUTSW @QK15622518 @LucasaEast @Burg1ess @yipengxie_utsw

[Fusion Conferences @Fusion_Conf]

🎉 Exciting News! 🎉
Registration grants have been released to support ECR's attending #ecDNA25! Don't miss the chance to engage with cutting-edge research & connect with experts in the field.🌟Find out more: https://t.co/7jjRcwxae4

[Arima Genomics @ArimaGenomics]

📢 [Live Webinar] Modern Biology of ecDNA in Cancer Through the Lens of #3DGenomics with Dr. @SihanSean

Discover how 3D genomic technologies are transforming our understanding of #ecDNA in small cell lung cancer (SCLC). Plus, learn how ecDNA drives tumor evolution, therapy resistance, and key interactions between MYC and distant loci.

👉Register Here: https://t.co/Bb5dujEyvx

@CRI_UTSW @UTSWCancerBio @GDDgradprogUTSW @utswcancer

[The Nobel Prize @NobelPrize]

Happy International Women’s Day!

We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award.

Tell us about the women who inspire you the most - and why

#InternationalWomensDay

[Sihan Wu 吴思涵 @SihanSean]

I will present our lab's most recent research. Look forward to meeting new collaborators and friends!

[Fusion Conferences @Fusion_Conf]

🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this November. More details➡️https://t.co/zM6i6rnTbA #ecDNA25 #eccDNA #ecDNA @zz_zhaozhang @B_Regenberg

[Sihan Wu 吴思涵 @SihanSean]

And I believe this should be the new norm.

[Sihan Wu 吴思涵 @SihanSean]

🥳Review paper online: Modern biology of extrachromosomal DNA: A decade-long voyage of discovery👏You'll find modern ecDNA biology uncovered over the last ten years👍Kudos to my trainees who put everything together❤️Thank @CancerGrand for support!
https://t.co/iqPn8NbK55

[Sihan Wu 吴思涵 @SihanSean]

And here is a sneak peek of what is happening in the Wu lab.

[bioRxiv Cancer Bio @biorxiv_cancer]

Transcription Machinery Anchors ecDNAs to Mitotic Chromosomes for Segregation https://t.co/tYTkeC9fRK #biorxiv_cancer

[Sihan Wu 吴思涵 @SihanSean]

@QingZhangLab Someone got a pair of push-up bars, and then we had a competition😂

[Sihan Wu 吴思涵 @SihanSean]

I love my LEGO! Luckily no one stole it. And y'all need to do push up everyday. Don't let your not-young-any-more PI beat you up on sports.

[Stanley Lim @stanleylim93]

White elephant gift exchange today for @SihanSean lab with X'mas cake from
Paris Baguette! Post-party lab dinner at Ngon Vietnamese Kitchen for Pho and Papaya Salad with Beef Jerky (unexpectedly good combination🤤)! Happy holidays everyone!! @YoonKimUTSW @Burg1ess @yipengxie_utsw

[Stanley Lim @stanleylim93]

White elephant gift exchange today for @SihanSean lab with X'mas cake from
Paris Baguette! Post-party lab dinner at Ngon Vietnamese Kitchen for Pho and Papaya Salad with Beef Jerky (unexpectedly good combination🤤)! Happy holidays everyone!! @YoonKimUTSW @Burg1ess @yipengxie_utsw

[Sihan Wu 吴思涵 @SihanSean]

I shared our protocol for doing FISH on FFPE with many labs before. Then I realized, why not publish it to make it more accessible to everyone? My lab manager, Collin, is the master of this technique and makes it work every single time.

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

OUT NOW in @JoVEJournal: 📺Watch this optimized technique, suitable for clinical FFPE samples, to detect amplified genes developed in CRI's @SihanSean Lab #relentlessdiscovery https://t.co/D7R2msDHTR

[Stanley Lim @stanleylim93]

October lab dinner is spicy mala food at Sichuan Folk! Mapo tofu is my must-order food as always. Also good pairing with Mango Creme Brulee Cake from 85°C Bakery for the October birthday!! @SihanSean @LucasaEast @Burg1ess @yipengxie_utsw

[Sihan Wu 吴思涵 @SihanSean]

@daniela_oaks So much fun today!!! I kept bugging @yogeshgoyallab today, asking single-cell questions.

[Sihan Wu 吴思涵 @SihanSean]

Another reason why you should apply to the Forbeck forum. The best filet mignon so far. Not to mention the three perfectly paired wines. Well I do learn a lot from my fellow scientists today by the way.