S Grandjean Lapierre (he/him)

White water paddler and lamp enthusiast
Assistant professor @UMontreal
Clinical Scientist @CRCHUM @PasteurMG & @McGill_TB
Diagnostics and epidemiology of TB

[Sage Bionetworks @Sagebio]

“Acoustic epidemiology” will help transform the diagnosis of #Tuberculosis. The open CODA TB @DR_E_A_M Challenge is in its continuous #benchmarking phase, now evaluating models for generalizable performance in TB diagnosis from cough recordings. Learn more https://t.co/xDNjRmtSpm

[S Grandjean Lapierre (he/him) @SimonGLapierre]

#TB affected rural communities have distinct social network structures, transmission dynamics and disease elimination perspectives. Work from @CPando4 and colleagues in #BMCPublicHealth.

@pasteurMG
@SwissTPH
@IGHSatUCSF
@CentreValBio
@StonyBrookMed

https://t.co/3aC61KLkMN

[S Grandjean Lapierre (he/him) @SimonGLapierre]

https://t.co/S8NM4Bkqef

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Work we do on #DigitalCoughMonitoring @CRCHUM, @UdeM & @McGill_TB with partners such as @hyfeapp and @GoogleHealth featured in @TIME magazine. “The ultimate goal is to mine cough data to see if distinct signatures materialize that would distinguish, lung diseases”…including #TB

[S Grandjean Lapierre (he/him) @SimonGLapierre]

A must read - Thanks to @stefan_niemann 's team, co-authors and all the @crypticproject collaborators including @pasteurMG for making this possible.

[Stefan Niemann @stefan_niemann]

So proud - great collaborative work on urgently needed data on bedaquiline/clofazimine resistance mechanisms published @crypticproject
@FZBorstel
@trans_evo
@medinflame
@DZIF_
@tbgenomics
@TBnet_EU
@_K_E_C
https://t.co/qAuHMYZzHI

[S Grandjean Lapierre (he/him) @SimonGLapierre]

On #WorldTBDay2023, I’m pleased to be joining Frontiers in Tuberculosis (coming soon) as a Review Editor.

Interested in being part of the editorial team? Contact [email protected] to apply.

#TBAwareness #tuberculosis

[McGill TB Centre @McGill_TB]

Apply!

Our @McGill_TB is pleased to offer 3 short, summer courses on tuberculosis

- Advanced TB Diagnostics | May 29 - June 2
- TB Research Methods | June 5-9
- Engaging all health providers to End TB: Public-Private Mix | June 12-16

https://t.co/QApxUQLF1F

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Our paper comparing @nanopore and @illumina for TB DST and clustering now out in @LancetMicrobe. Highly concordant 5/12 SNP clusters, 100% concordance at resistance SNPs, 4/60000 indel discordances. Thanks to @ZaminIqbal @Leniaina @MBhall88 & team. https://t.co/VaojmOt90W

[DREAMchallenges @DR_E_A_M]

Just launched: CODA TB Challenge to predict TB diagnosis from cough recordings.
Register at https://t.co/KBfqngbuRx
@acattamanchi @R2D2_TBNetwork @WalimuNGO @UCSF_CTB @SimonGLapierre @CRCHUM @ifakarahealth @Sagebio

[Centre de recherche du CHUM @CRCHUM]

Novembre marque la mise en place d’un #DataSet clinique + acoustique améliorant le triage des diagnostics de maladies respiratoires. L’équipe du Dr @SimonGLapierre contribuera à un concours ouvert à la communauté scientifique + experts #IA en santé
Infos👇
https://t.co/HAc5cqIZJJ

[Zamin Iqbal @ZaminIqbal]

New paper led by @mbhall88 and collaborators! Evaluating @nanopore as a replacement/complement for Illumina for TB: drug resistance and clustering. Spoiler: you can get equivalent clustering and identical resistant predictions (with 30x depth). 1/n
https://t.co/1vuCivWtwA

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Indeed @mbehr_mcgill & @justin_denholm this is a clinical challenge. 🤔 If WHO endorses that 1.7 billion people have LTBI and an expected positive Quantiferon-TB test, is one uveitis out of 4 due to active ocular TB disease?

[Justin Denholm @justin_denholm]

@robshorten @mbehr_mcgill @zchagla It’s part of the diagnostic workup for paucibacillary conditions like TB uveitis, for example. Pretty limited, and the evidence for that is weak, but it’s what we’re stuck with currently.

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Thanks to @JuanCGabaldon & @Carlos_Chaccour for pushing the limits of #acousticepidemiology

[Dr. Carlos Chaccour 🦟🔚💊 @Carlos_Chaccour]

Adventuring in new territories with our #ArtificialIntelligence and cough project using @hyfeapp at @ClinicaNavarra.

Very nice work from @JuanCGabaldon @JulianeChaccour @MGalvosas et al.

With great support from @SimonGLapierre via @chumontreal

https://t.co/NndA10Kxc2

[S Grandjean Lapierre (he/him) @SimonGLapierre]

The 2021 WHO catalogue of MTBC mutations associated with drug resistance. A long term global effort including collaboration with Malagasy scientists @pasteurMG @Leniaina https://t.co/M1b3LseANK

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Cool work from @philipwfowler and the @crypticproject team, leveraging citizen science for #TB DST methods assessment https://t.co/bV3ytkKYja

[S Grandjean Lapierre (he/him) @SimonGLapierre]

À la recherche d'excellents étudiants intéressés par l'épidémiologie moléculaire et la tuberculose! Belle opportunité de Maitrise en #bioinformatique avec les équipes de @martinalexsmith @ChuSteJustine et mon laboratoire @CRCHUM

[Martin Smith @martinalexsmith]

Nerd alert! 🦠🤓🧬 @SimonGLapierre and I are seeking a Master's #student for the #bioinformatics program at @UMontreal to work on rapid molecular profiling of #tuberculosis using #nanopore sequencing.

[Arthur Mortha @nkg2d1]

FINALLY BACK! Kicking off the CIHR New Investigator Forum #OurFutureOurIIINIF with this beautiful group of exceptional new health research talent in 🇨🇦 @CIHR_IRSC @CIHR_IG - RT, share and tag to connect!

[S Grandjean Lapierre (he/him) @SimonGLapierre]

https://t.co/iyJXZ1t0eJ

[EMBL @embl]

Estimates suggest around 10 years of progress in reducing the global burden of #TB has been lost due to the COVID-19 pandemic.

Find out how sequencing of the pathogen genome can help improve therapy choice for this terrible disease. #WorldTBDay #EndTB

https://t.co/qeAkhIPCDG

[S Grandjean Lapierre (he/him) @SimonGLapierre]

Another critical step towards standardization of #TB genotypic drug susceptibility testing. Thanks to
@WHO, @FINDdx and all data contributors including
@pasteurMG. https://t.co/0IeifUDv2k