I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please RT 💚
Increased KRAS mutant allele dosage is an important negative prognostic feature that will need to be integrated into clinical practice as we move into the era of 🎯 RAS-directed therapeutics for PDAC.
🔸️
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival
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https://t.co/6tFBTKV2yl
My mom is dying from pancreatic cancer.
She’s only 65.
She’s my best friend outside my wife and daughter.
I’m in the hospital with her right now (she’s sleeping) as I write this.
She’s been in the hospital for almost the last two months.
@jdpereira Here in Houston it’s not very pleasant to walk. But when I still lived in my home country I was also walking a lot every day. Miss it so much!
Algül Lab is hiring a new postdoctoral researcher! If you are excited to work in the pancreatic cancer field under the funded BMBF consortium, we are looking forward to seeing your applications! Please spread the word!😊#pancreaticcancer#postdoc
https://t.co/CgUqDpMDRv
#PancreaticCancer & #ArtificialInteligence.
Cao https://t.co/xAB6q2Vb24. published a paper in Nature (20Nov23 online) claiming an (AUC) of 0.986–0.996 for detection of pancreatic lesions including adenocarcinoma (#PDAC) using non-contrast CT.
BUT, there is a BIG problem. (flow me for the answers)
The training and testing was in cohorts with very high rates of known pancreatic cancers and known lesions. In "real" real world testing of the general population, where the incidence of occult pancreatic cancers is <0.001, the false positive rate would be huge compared to true positive (see PMID: 14731128 as an example).
The key is to screen for occult PDAC in patients with a high risk for pancreatic cancer (PMID: 35704792) and with early signs and symptoms (PMID: 35065983).
The new PANDA tool will fail as a CT screening tool for detection of occult PDAC in a general population. The utility will likely be as an aid to radiologist that are not experts at reading a non-contrast CT of the pancreas. Period.
The solution to the stratification problem of defining high, and very high risk sub-populations will be discussed later. Stay tuned to @davidcwhitcomb .
https://t.co/Ons8LdafCi
Note: PMID is the PubMed number on the https://t.co/CbxJgUExlK web site.
@PanCAN@NatPancFdn@UPMC@lustgartenfdn@PancPathologist@Aiims1742@ArielMedicine #pancreatitis #deeplearning #DigitalHealth #PrecisionMedicine @AmCollegeGastro@PittGILiverNutr@GIPapachristou
We are excited to share our preprint on the effects of RAS-GTP inhibition in preclinical models of PDAC, using RMC-7977, a potent inhibitor of GTP-bound RAS proteins. This preclinical agent is related to RMC-6236, currently in clinical trials. https://t.co/u256sIWNwl
November is Pancreatic Cancer Awareness Month! 🎗📆💜 Head to https://t.co/yhV9zv04fo to learn how you can get involved and raise awareness in our community this month. #PanCANAwareness
We are excited to share our #mattersarising piece out today in @Nature ! Let us walk you through the main take-homes, which we believe are of utmost importance to the entire #ferroptosis field! 1/n
https://t.co/cl8TSGEU8R