Nick Hand, PhD

Irish by birth, US by choice, scientist by trade. ✊🏿 Black Lives Matter ✊🏿

[Nick Hand, PhD @SomePaddy]

@karenlytle711 @McJesse ...to see the manager?

[Kelton Minor @keltonminor]

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵

[Malcolm Nance @MalcolmNance]

Straight up. Trump is a traitor & He is Putins Bitch. That’s it. That’s the tweet.

[JHEP Reports @JHEP_Reports]

🟪NEW Article in press❕

Deep metabolic phenotyping of humans with protein-altering variants in TM6SF2 using a genome-first approach

🔓#OpenAccess at 👉https://t.co/kuvC3xbq9H

#LiverTwitter
#MASLD
#MASH

[Nick Hand, PhD @SomePaddy]

@TGTatum4_3 @LASHYBILLS 100% falls under "fighting words". Lawsuit isn't going anywhere.

[Rachel Stubler @RachelStubler]

Happy #FluorescentFriday! This micrograph of the mouse small intestine is a finalist in the #Proteintech microscopy image contest. Voting opens on Monday!

#FluorescenceFriday #microscopy #sciart #histoart #pathart #bioart #intestine

[Nick Hand, PhD @SomePaddy]

@ElieNYC Definitely cause for thanksgiving.

[Nick Hand, PhD @SomePaddy]

@Erik_Thomas82 @PHLEaglesNation Yeah, I thought it was just me

[Michael Beschloss @BeschlossDC]

Important and be forewarned. Trump said this to crowd tonight:
“Get out and vote! Just this time. You won’t have to do it anymore. Four more years. You know what? It’ll be fixed! It’ll be fine!…In four years, you don’t have to vote again.”

[Nick Hand, PhD @SomePaddy]

@BenBCDE @sirDukeDevin @MissesBun Big Star Wars fan, bad at spelling?

[Nick Hand, PhD @SomePaddy]

@JustVent6 @RonFilipkowski He used @RocketMoneyApp to save $45 million a month?

[Nick Hand, PhD @SomePaddy]

@blekhman You seem... upset

[Nick Hand, PhD @SomePaddy]

@NuckChorris16 @NotTonkaToy_1 Only Zuul.

[Nick Hand, PhD @SomePaddy]

@acnewsitics She "immigrated" from San Diego, California, wherever that is.

[Chris Illuminati @chrisilluminati]

This is the worst SNL cold open ever

#Debates2024

[Tristan Snell @TristanSnell]

Fun fact about the debate:

It’s the first time the Secret Service has allowed a convicted felon to get this close to the President of the United States.

[Akilah Hughes @AkilahObviously]

So it’s guy lying super loud versus guy telling the truth super soft.

[Nick Hand, PhD @SomePaddy]

@breakliquid @plasmidsaurus Next: quantum sequencing results delivered before you even start an experiment.

[euan ashley @euanashley]

Exercise may be the single most potent medical intervention ever known. Its benefits in prevention outstrip any known drugs: 50% reduction in the risk of cardiovascular disease, 50% reduction in the risk of many cancers, positive effects on mental health, pulmonary health, GI health, bone health, muscle function. You name it. Exercise helps. In fact, the ability to exercise over long distances was likely key to our evolution as a species because the availability of densely caloric foods due to persistence hunting allowed our energy-avid brains to enlarge. And yet, we have had very little insight into the molecular basis of these magical effects...until now!

Published in yesterday's Nature and featured on the cover was work from our consortium that represents the culmination of a couple of decades of pitching ideas to the NIH, forming a consortium, planning experiments, executing those experiments, and analyzing data at unprecedented scale, all aimed at enhancing our understanding of the molecular transducers of exercise.

It was a major effort from so many in our consortium (playfully named MoTrPAC) and is the first landmark paper of many more to come. This first paper focused on the multi-tissue, multi-omics of treadmill exercise in rats. Specifically, we report the effects of eight weeks of treadmill running on the transcriptome, the epigenome, the proteome, the metabolome, the lipidome and the immunome of a broad range of tissues (in fact, 9,466 assays across 19 tissues, 25 molecular platforms, and 4 training time points).

The result is the most comprehensive molecular map of exercise ever created. At Stanford, my colleague @MWheelerMD and I co-lead the bioinformatics center and it was our team's duty and privilege to ingest the data, QC the data, help analyze the data, and make the data available to the world. Various tools available at our data hub allow you to explore the data, visualize it, and download it for your own use.

Have fun! And stay tuned for human data that will be coming.

So many people to thank who made this possible (see the paper for details). Special shout out to the primary analysts and authors: David Amar, Nicole Gay, & Pierre Jean Baltran.

Paper: https://t.co/0nhXdfhxx0
Data hub: https://t.co/NxTHsVdfRp

[Nick Hand, PhD @SomePaddy]

@ElieNYC Bring me a shrubbery!