SPECIFICANCER

Dissecting the Tumour Specificity of Cancer Drivers
@CRUKresearch Grand Challenge team funded in partnership with @TheMarkFdn

[Michelle Mitchell @Michelle_CRUK]

Fascinating latest findings from @cancergrand @SpecifiCancer team exploring how cancers in different parts of the body use unique strategies to avoid attack by the immune system. This innovative thinking could lead to more effective cancer treatments https://t.co/l5g8npNOku

[Cancer Grand Challenges @CancerGrand]

A year of scientific creativity: check out Discover, our annual progress magazine showcasing the exciting discoveries our global community of teams have made over the past year:

https://t.co/QElQZUx2lQ

#CancerGrandChallenges #sciencenews

[Owen Sansom 🏳️‍🌈 @owen_sansom]

We found that one of the reasons why Apc is a potent tumour suppressor in the intestine is that once it’s lost in a stem cell, notum a wnt target gene will inhibit wnt signalling in neighbouring stem cells. This allows Apc mutant cells to “win”. More details in Dusty’s thread

[CRUK Scotland Inst @CRUK_SI]

How do mutants win the game of clones? 🏆🤷
In this week's @Nature, Dustin Flanagan @CRUK_BI + @owen_sansom, with the great @KatajistoLab and @SPECIFICANCER team, find out how APC mutations cause #cancer in the #gut ... with help from NOTUM
A 🧵by Dustin
1/11

[Cancer Grand Challenges @CancerGrand]

Congratulations to @SpecifiCancer and @KatajistoLab on their latest discovery in @nature! The team identified the molecule Notum as a key player in the early stages of apc-driven #colorectalcancer. - https://t.co/LNSpVGer7l @owen_sansom @CRUK_BI #specificancer

[Cancer Grand Challenges @CancerGrand]

Amy Schade and Karen Cichowski of our SPECIFICANCER team discuss the importance of mentorship. Amy joined Karen's lab (@BrighamWomens) as a postdoctoral research fellow in 2019.

Find out more about their relationship: https://t.co/pJwbWYCTDC

[Nature Communications @NatureComms]

The @KevinHaigisLab and @peter_j_park labs show that KRAS mutations across multiple cancer types have allele- and tissue-specific mutagenic origins, comutation patterns, and dependency interactions

https://t.co/XC7whW86QU

#cancerresearch @NatResCancer

[SPECIFICANCER @SpecifiCancer]

Check our second advocate/scientific team's conversation video. Patient advocate, @helenkmatthews interviewed @owen_sansom, a professor of @CRUK_BI and the @UofGlasgow. @owen_sansom talked about how he has approached the team's scientific goal.
https://t.co/MOcpp7PN5h

[Cancer Grand Challenges @CancerGrand]

You don't need to be a cancer researcher to lead a #CancerGrandChallenges team - we're looking for new thinking from diverse teams to address our challenges.

Download our Expression of Interest guidelines to find out how you can apply your expertise: https://t.co/eXXBBm1FxD

[SPECIFICANCER @SpecifiCancer]

Team's patient advocate representative, Fran Visco has invited two leading scientists, Dr. Elledge and Dr. Cichowski to the conversation. They explained the team's research to the public.
Watch “Specificancer Interview” on #Vimeo https://t.co/s7GhKM79mJ

[Cancer Grand Challenges @CancerGrand]

Meet the #CancerGrandChallenges teams

#SPECIFICANCER led by Prof Stephen Elledge are unravelling the riddle of #tissuespecificity in cancer, to ensure cancer types are best matched to therapies for increased #patientbenefit. Co-funded by @TheMarkFdn.

https://t.co/KNr0hcuktp

[National Cancer Institute @theNCI]

#CancerGrandChallenges partnership between @CR_UK and NCI has been ceremonially signed. “The two largest funders of cancer research unite to define a new era in research and discovery for the future benefit of patients with cancer.” – Dr. Iain Foulkes @Iain_CRUK @NCIDirector

[The Clevers Lab @TheCleversLab]

PhDs @BeumerJoep and @jeltevdvaart from the group of @HansClevers set up collaboration with to show that #SARSCoV2 may infect cells in the intestine. Just out in @ScienceMagazine!

[HHMI @hhmi_science]

To prevent the spread of #COVID19, HHMI Investigator Steve Elledge’s lab has emptied out. However, he, Nouran Abdelfattah (@Abdelfattah_NS) (shown), & six other researchers have continued working in person, under new safety rules, studying the coronavirus: https://t.co/sEFurOWoJO

[Science and Innovation at Cancer Research UK @CRUKresearch]

Today is #GivingTuesdayNow, a global day of unity and giving. The #coronavirus outbreak has slowed us down, but we will never stop. If you can, please visit https://t.co/g7ct88Tdr1 to make a donation towards our life-saving research

[Science in Boston @ScienceinBoston]

Three new studies from @KevinHaigisLab at @BIDMChealth have revealed that cancer disease incidence and severity are influenced by the specific type of #KRAS mutation, as well as by the tissue in which the mutation is located. https://t.co/fw5thSeHbw

[Kevin Haigis Lab @KevinHaigisLab]

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation https://t.co/jasbQtibEH

[Cancer Research UK @CR_UK]

We’re committed to equality, diversity and inclusion in everything that we do. Because cancer doesn’t discriminate. This year, we’re celebrating #Pride Month by sharing what Pride means to our staff and supporters. For more info visit https://t.co/KLUThbw1EX #PrideinResearch

[Cancer Research UK @CR_UK]

Fran keeps our #CRUKGrandChallenge science focused on the wellbeing of the patients. Listen below👇 and read more here 👉 : https://t.co/nmAaxb2uUs

[SPECIFICANCER @SpecifiCancer]

@SpecifiCancer team had a successful video meeting. Collaborative research team moves forward to the goal.